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Cell Therapy
Cell therapy is a rapidly developing area, drawing on cell biology, molecular biology, virology, immunology, cell quantitation techniques and biomedical engineering. It has potential in many clinical settings, in the treatment of cancer and other diseases. This volume in the series Cancer: Clinical Science in Practice examines the current state and future prospects of cell therapy, which seems likely to have an even more profound impact on health care than did the production of proteins by recombinant DNA technology. The coverage is broad, including the scientific principles of haematopoietic cell therapy, the technology of cell collection and preparation, current and likely future clinical applications of cell therapy, and the principles and practice of cellular immunotherapy. Up-to-date and authoritative, volumes in this series are intended for a wide audience of clinicians and researchers with an interest in the applications of biomedical science to the understanding and management of cancer.
Recombinant DNA Research
Documents relating to "NIH guidelines for research involving recombinant DNA molecules".
Bone Marrow Purging and Processing
This volume assesses research findings as well as the clinical aspects now in use for selectively separating subpopulations of cells from bone marrow. It examines a full range of purging processes including transplantation programs, cryopreservation, cell isolation and cell growth, specificity testing and quality control, as well as the development of alternative sources of stem cells, including peripheral blood and cadaveric marrow. It also presents the conditions necessary to optimize graft toxicity and bone marrow transportation and addresses newer techniques of gene probing/processing as well as mechanisms of genetic alteration including electroporation.
Racing to a Cure
Racing to a Cure is not a cancer memoir. It is a cancer cure memoir. In 1998 Neil Ruzic was diagnosed with mantle-cell lymphoma, the deadliest cancer of the lymph system, whose spread is reaching epidemic levels in the U.S. and Europe. Instead of following recommended courses of chemotherapy and radiation, he took control of his treatment by investigating cures being developed in the nation's cancer-research laboratories. Although chemotherapy harms the immune system and is increasingly demonstrated to be an ineffective long-term cure for the vast majority of cancers, it remains the standard treatment for most cancer patients. Ruzic, a former scientific magazine publisher and originator of a...
Advances in Bone Marrow Purging and Processing
Surveys the latest research discoveries and current clinical procedures for selectively separating and analyzing subpopulations of cells from bone marrow. Over 400 internationally renowned experts offer contributions on such topics as approaches for using DNA sense and antisense probes, combinations of elutriators and immunomagnetics, expanded cytokines applications, new techniques for the removal of tumor cells from autologous bone marrow and T cells from allogeneic grafts.
Aplastic Anemia and Other Bone Marrow Failure Syndromes
During the past decade, there have been numerous direct and indirect scientific contributions to both the etiology and therapy of aplastic anemia and related bone marrow failure syndromes. Clinical observations, such as autologous bone marrow recovery after conditioning with immunosup pressive agents for bone marrow transplantation; failure to achieve en graftment in some identical twins without prior immunosuppressive ther apy; and hematologic response to immunosuppressive agents, have led to the concept of immune-mediated etiology of acquired aplastic anemia. Such a concept was further strengthened by laboratory findings, implicat ing the role of activated cytotoxic T lymphocytes and abnor...
