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P2 Purinoceptors
Many different pathological conditions are currently under investigation as therapeutic targets of purines including cancer, cardiovascular conditions, behavioural disorders, inflammation, immunoregulation, and neuroendocrine function. This book draws together research on all aspects of P2 purinoceptors and discusses their use in different therapeutic areas.
Neurochemistry
Proceedings of the 11th European Society for Neurochemistry Meeting held in Groningen, The Netherlandes, June 15-20, 1996
Life Scientific Philosophy, Phenomenology of Life and the Sciences of Life
This collection brings to the public the fruits of the groundlaying work on the philosophy/phenomenology of life presented in some 30 volumes of the Analecta Husserliana, and inaugurates a new phase in philosophy/phenomenology - a truly radical turn. As Tymieniecka in her introduction puts it, the time is ripe to abandon the prejudices against empiria and set aside in a `second position' the epistemological/constitutive criterion of validity and truth - without, however, abandoning it. To the contrary: recognising with our present culture the overwhelmingly superior validity of the pragmaticity test, which science indubitably applies in its `verification' of technology, philosophy/phenomenol...
Colloquial Spanish in Context
Colloquial Spanish in Context examines subtle and difficult grammar points as they naturally appear: in normal, everyday Spanish as seen in comic strips.
Spanish B for the IB Diploma Student's Book
Develop confident linguists, who appreciate other cultures with this course, based closely around the IB's desired learner profile. This text caters for Language B - students learning Spanish as a second language at Standard and Higher levels. It includes a starter unit to help bridge the gap from pre-16 exams into the distinctive requirements of the IB Diploma. - Builds language skills through carefully crafted tasks and grammar practice - Improves exam performance with activities for all aspects of IB Spanish assessment - Promotes global citizenship and an appreciation of Hispanic culture through stimulus material, including a particular emphasis on the Americas Each copy includes an Audio CD providing tracks for the listening exercises
Nucleotides and their Receptors in the Nervous System
The study of purinergic mechanisms has for long been focused on the actions of the nucleoside adenosine, whereby the contribution of nucleotides to the signaling systems has been underestimated.Based on the proceedings of a IUPHAR Satellite Conference held in Leipzig, Germany, this book offers a comprehensive update and overview of nucleotide release, the structure and function of nucleotide receptors, nucleotide-metabolizing ecto-enzymes as well as the physiological functions of nucleotides in the nervous system. The physiology and molecular biology of receptors for ATP and other nucleotides are examined, as are the physiology and molecular biology of enzymes that hydrolyze extracellular nucleotides.At present, a pharmacology of the nucleotide signaling system is being developed. Of particular interest is the production of receptor subtype-specific antagonists and of drugs that selectively affect the extracellular lifetime of the nucleotide.An excellent source of reference for institutes of pharmacology, biochemistry, neurology, zoology, and physiology, and for the pharmaceutical industry.
Purinergic Signalling and the Nervous System
In the first 20 years that followed the purinergic signalling hypothesis in 1972, most scientists were sceptical about its validity, largely because ATP was so well established as an intracellular molecule involved in cell biochemistry and it seemed unlikely that such a ubiquitous molecule would act as an extracellular signalling molecule. However, after the receptors for ATP and adenosine were cloned and characterized in the early 1990s and ATP was established as a synaptic transmitter in the brain and sympathetic ganglia, the tide turned. More recently it has become clear that ATP is involved in long-term (trophic) signalling in cell proliferation, differentiation and death, in development...
A Century of Retablos
In recent years, tremendous attention has been focused on the Arts of 18th and 19th century New Mexico. This colonial period benefited from a creative and religious community that populated the region. Retablos, painted panels depicting saints worshiped in churches and private homes, were an important part of the rich culture. The Lyon Collection beautifully illustrates the breadth of Retablo painting by exmaining specific Santo's stylistic development as well as the iconography and social history of each painting. This landmarl publication will be of great use to the ongoing study of colonial southwestern art and history. 107 colour illustrations
