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Antineoplastic and Immunosuppressive Agents
Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons ...
Immunotherapy for Gastrointestinal Cancer
This book is about the manipulation of the immune system as a therapeutic approach to gastrointestinal cancer and its clinical applications, exploring therapeutic approaches which might be taken under the broad banner of immunotherapy. Starting by introducing concepts of modern immunology, the clinical applications of immunotherapy are then discussed. The reader will learn about the three broad classes of immune therapeutic agents: cell-based treatment; antibody therapy; cytokine application and the key effector cells and mechanisms which might cause tumour rejection. The reverse side of this equation, the genetic and molecular mechanisms which the tumour can use to escape immune control and regulation, is also discussed. Through reviewing the most up-to-date evidence, this volume provides an overview of the important scientific lessons learned from past failure of immunotherapeutics in the clinic and highlights more positive recent data, coupled to practical guidelines for clinical usage. Written by a team of worldwide experts, this is an indispensable guide for medical oncologists, surgical oncologists, radiation therapists, pharmacists, oncology nurse specialists.
Applied Multivariate Research
Using a conceptual, non-mathematical approach, the updated Third Edition provides full coverage of the wide range of multivariate topics that graduate students across the social and behavioral sciences encounter. Authors Lawrence S. Meyers, Glenn Gamst, and A. J. Guarino integrate innovative multicultural topics in examples throughout the book, which include both conceptual and practical coverage of: statistical techniques of data screening; multiple regression; multilevel modeling; exploratory factor analysis; discriminant analysis; structural equation modeling; structural equation modeling invariance; survival analysis; multidimensional scaling; and cluster analysis.
Mechanism of Action
The idea for publishing these books on the mechanism of action and on the biosynthesis of antibiotics was born of frustration in our attempts to keep abreast of the literature. Gone were the years when we were able to keep a biblio graphy on antibiotics and feel confident that we could find everything that was being published on this subject. These fields of investigation were moving for ward so rapidly and were encompassing so wide a range of specialized areas in microbiology and chemistry that it was almost impossible to keep abreast of developments. In our naivete and enthusiasm, however, we were unaware that we were toying with an idea that might enmesh us, that we were creating an entit...
Mechanism of Action of Antimicrobial and Antitumor Agents
This volume is the third in the series devoted to Antibiotics initiated by Springer Verlag in 1967. The first two volumes were devoted to the Mode of Action of Antibiotics and Biogenesis, respectively and were received graciously. During the intervening years these two works have been used often by research workers and students alike and have been quoted extensively. Although a number of other excellent treatises on antibiotics have appeared, the Springer series has set a standard for thoroughness and quality that meets the need of the scientific community. It is against this background that the present Editors set about the preparation of a third volume in the Series on Antibiotics. Since t...
The Oxford Handbook of Language Prosody
This handbook presents detailed accounts of current research in all aspects of language prosody, written by leading experts from different disciplines. The volume's comprehensive coverage and multidisciplinary approach will make it an invaluable resource for all researchers, students, and practitioners interested in prosody.
Metabolic Pathways
Metabolic Pathways, Third Edition: Volume IV: Nucleic Acids, Protein Synthesis, and Coenzymes focuses on the metabolic pathways of the major biological constituents of living organisms, namely, nucleic acids, proteins, and coenzymes. The biosynthesis and metabolism of purines and pyrimidines, nucleotides, riboflavin and related compounds, and vitamin B6 are discussed. The biogenesis and metabolism of thiamine and folic acid are also considered. This volume is comprised of seven chapters and begins with an analysis of metabolic control and enzymology of purines and pyrimidines such as inosinic acid and nucleotides. The next chapter is devoted to the biosynthesis and metabolism of nucleotides ...
