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Monster
On 28 August 1984, Josef Fritzl drugged his teenage daughter with ether and imprisoned her in an underground bunker behind eight locked doors. Over the following twenty-four years, he raped and abused her, never letting her or the children she bore him out of the dark, windowless cellar. Based on 150 new interviews with psychologists, neighbours, colleagues and friends who knew Fritzl, as well as the insight of his own chilling confession, Allan Hall reconstructs the monstrous personality behind this hideous crime. He exposes Josef Fritzl's dark past in Nazi Austria, his previous conviction as a rapist, the appalling conditions in which Elisabeth and her children were kept and her astonishingly brave conduct while held prisoner. Including exclusive photographs and previously unseen evidence, this is a truly heart-stopping record of one of the most elaborate and disturbing cases of abuse in modern times.
Girl in the Cellar - The Natascha Kampusch Story
When Natascha Kampusch made her bid for freedom on 23 August 2006 after eight years held captive in a seemingly ordinary Austrian suburban house, her story horrified and astonished the entire world. How did she survive a childhood locked in a cellar What sort of young woman had emerged What kind of man was Wolfgang Priklopil, her abductor - and what demands had he made of her As the days and weeks passed and Natascha's TV interview failed to quell the curiosity, so the questions began to change. What exactly was the relationship between abductor and hostage Why had Natascha waited so long to escape when it seemed there had been other, earlier opportunities Did Natascha's parents know Priklop...
The Unfolded Protein Response and Cellular Stress, Part A
This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation. The authors explain how these methods are able to provide important biological insights. - This volume provides descriptions of the occurrence of the UPR, methods used to assess it, pharmacological tools and other methodological approaches to analyze its impact on cellular regulation - The authors explain how these methods are able to provide important biological insights
Small GTPases in Disease, Part B
The critically acclaimed laboratory standard for more than 40 years, Methods in Enzymology is one of the most highly respected publications in the field of biochemistry. Since 1955, each volume has been eagerly awaited, frequently consulted, and praised by researchers and reviewers alike. Now with over 400 volumes (all of them still in print), the series contains much material still relevant today—truly an essential publication for researchers in all fields of life sciences. Methods in Enzymology is now available online at ScienceDirect — full-text online of volume 1 onward.
RNA Turnover in Eukaryotes: Nucleases, Pathways and Analysis of mRNA Decay
Specific complexes of protein and RNA carry out many essential biological functions, including RNA processing, RNA turnover, RNA folding, as well as the translation of genetic information from mRNA into protein sequences. Messenger RNA (mRNA) decay is now emerging as an important control point and a major contributor to gene expression. Continuing identification of the protein factors and cofactors, and mRNA instability elements responsible for mRNA decay allow researchers to build a comprehensive picture of the highly orchestrated processes involved in mRNA decay and its regulation. - Covers the nonsense-mediated mRNA decay (NMD) or mRNA surveillance pathway - Expert researchers introduce the most advanced technologies and techniques to identify mRNA processing, transport, localization and turnover, which are central to the process of gene expression - Offers step-by-step lab instructions, including necessary equipment and reagents
Serpin Structure and Evolution
Serpins are a group of proteins with similar structures that were first identified as a set of proteins able to inhibit proteases. This volume in the Methods in Enzymology series comprehensively covers this topic. With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems. - This volume in the Methods in Enzymology series comprehensively covers the topic of serpins - With an international board of authors, this volume covers subjects such as Crystallography of serpins and serpin complexes, Serpins as hormone transporters, and Production of serpins using cell free systems
RNA Helicases
This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. - This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases - The contributions in this volume cover the broad scope of methods in the research on these enzymes
Glycobiology
In this 3 volume collection focusing on glycomics, readers will appreciate how such discoveries were made and how such methods can be applied for readers' own research efforts - Each chapter has been designed so that enough scientific background will be given in each chapter for further development of methods by readers themselves - Useful for all levels of scientists starting from the last years of colleges, graduate students, postdoctoral fellows to professors and to all levels of scientists in research institutes including industry
Guide to Yeast Genetics and Molecular Biology
Guide to Yeast Genetics and Molecular Biology presents, for the first time, a comprehensive compilation of the protocols and procedures that have made Saccharomyces cerevisiae such a facile system for all researchers in molecular and cell biology. Whether you are an established yeast biologist or a newcomer to the field, this volume contains all the up-to-date methods you will need to study "Your Favorite Gene" in yeast.Key Features* Basic Methods in Yeast Genetics* Physical and genetic mapping* Making and recovering mutants* Cloning and Recombinant DNA Methods* High-efficiency transformation* Preparation of yeast artificial chromosome vectors* Basic Methods of Cell Biology* Immunomicroscopy* Protein targeting assays* Biochemistry of Gene Expression* Vectors for regulated expression* Isolation of labeled and unlabeled DNA, RNA, and protein
Cilia, Part A
This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers cilia and includes chapters on such topics as electron microscopy of IFT in cilia and flagella, radial spoke isolation and assays, and biomechanical measurements of kinocilium. - Continues the legacy of this premier serial with quality chapters authored by leaders in the field - Covers cilia - Contains chapters on such topics as electron microscopy of IFT in cilia and flagella, radial spoke isolation and assays, and biomechanical measurements of kinocilium
