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Focusing on biosynthesis, this book provides readers with approaches and methodologies for modern organic synthesis. By discussing major biosynthetic pathways and their chemical reactions, transformations, and natural products applications; it links biosynthetic mechanisms and more efficient total synthesis. • Describes four major biosynthetic pathways (acetate, mevalonate, shikimic acid, and mixed pathways and alkaloids) and their related mechanisms • Covers reactions, tactics, and strategies for chemical transformations, linking biosynthetic processes and total synthesis • Includes strategies for optimal synthetic plans and introduces a modern molecular approach to natural product synthesis and applications • Acts as a key reference for industry and academic readers looking to advance knowledge in classical total synthesis, organic synthesis, and future directions in the field
How can the world's most powerful nations cooperate despite their conflicting interests? In Three-Way Street, Joshua S. Goldstein and John R. Freeman analyze the complex intersection defined by relations among the United States, the Soviet Union, and China over the past forty years. The authors demonstrate that three major schools of international relations theory--all game-theoretic, psychological, and quantitative-empirical approaches--have all advocated a strategy that employs cooperative initiatives and reciprocal responses in order to elicit cooperation from other countries. Critics have questioned whether such approaches can model how countries actually behave, but Goldstein and Freeman provide a wealth of detailed empirical evidence showing the existence and effectiveness of strategic reciprocity among the three countries between 1948 and 1989. Specifically, they establish that relations among the three countries have improved in recent decades through a "two steps forward, one step back" pattern. Their innovative and remarkably accessible synthesis of leading theoretical perspectives brilliantly illuminates the nature and workings of international cooperation.
This fully commentated and annotated text edition proves Lucian's "Alexander the False Prophet" to be a singular historical document of the history of religions in the 2nd and 3rd centuries AD, which has been corroborated by continuous archaeological discoveries.
Endovascular intervention - using medication and devices introduced through catheters or microcatheters placed into the blood vessels through a percutaneous approach - has emerged as a relatively new minimally invasive approach to treat cerebrovascular disease and possibly intracranial neoplasms. This textbook provides a comprehensive review of principles pertinent to endovascular treatment of cerebrovascular diseases and intracranial tumors, with a detailed description of techniques for these procedures and periprocedural management strategies. Particular emphasis is placed on expert interpretation of the quality of evidence provided and implications for practice related to endovascular procedures. This will be essential reading for clinicians working in interventional neurology and cardiology, endovascular neurosurgery, vascular surgery and neuroradiology.
Lucian's Alexander the False Prophet is the only literary testimony to a highly influential cult of the 'New Asclepios Glycon' which, as archaeological evidence continues to document, spread all over the eastern Mediterranean basin throughout the second and third centuries AD. This book offers an analysis of the complete manuscript tradition, a newly constituted text and a German translation. The extensive introduction deals with (1) the archaeological evidence, (2) the question of Lucian's historical reliability, (3) the reasons for Lucian's opposition to the oracle of Abonuteichos, (4) the institutions and the teaching of the cult at Abonuteichos. Furthermore, there is a commentary on all philological and historical questions and on those issues relevant to the history of religions. Lucian's Alexander is not one of his satirical bravuras, but a strikingly successful attempt at writing a work of contemporary history - a practical example of what the author himself has theoretically discussed in his work, How to Write History.
The school held at Villa Marigola, Lerici, Italy, in July 1997 was very much an educational experiment aimed not just at teaching a new generation of students the latest developments in computer simulation methods and theory, but also at bringing together researchers from the condensed matter computer simulation community, the biophysical chemistry community and the quantum dynamics community to confront the shared problem: the development of methods to treat the dynamics of quantum condensed phase systems.This volume collects the lectures delivered there. Due to the focus of the school, the contributions divide along natural lines into two broad groups: (1) the most sophisticated forms of the art of computer simulation, including biased phase space sampling schemes, methods which address the multiplicity of time scales in condensed phase problems, and static equilibrium methods for treating quantum systems; (2) the contributions on quantum dynamics, including methods for mixing quantum and classical dynamics in condensed phase simulations and methods capable of treating all degrees of freedom quantum-mechanically.
An in-depth study of processes of judicial transformation that enabled the success of human rights trials in Latin America.
In the last two decades, various states from the Global South have emerged as important players in international relations. Most popular among them is China. Brazil, India and South Africa have also taken essential roles in global and regional politics. Compared to traditional great powers, they can be labelled ’regional great powers’ or ’regional powers’ because their influence is - with the exception of China - concentrated on their neighbourhood. The impact of regions, meaning the impact of geography, on the economics and politics of regional powers is surprisingly understudied. This book analyses how geographical conditions influence the regional economics and politics of South Africa, allowing the author to delineate its region of influence.
In early 2011, widespread protests ousted dictatorial regimes in both Tunisia and Egypt. Within a few years, Tunisia successfully held parliamentary and presidential elections and witnessed a peaceful transition of power, while the Egyptian military went on to seize power and institute authoritarian control. What explains the success and failure of transitions to democracy in these two countries, and how might they speak to democratic transition attempts in other Muslim-majority countries? Democratic Transition in the Muslim World convenes leading scholars to consider the implications of democratic success in Tunisia and failure in Egypt in comparative perspective. Alongside case studies of ...