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Macrolide Antibiotics: Chemistry, Biochemistry, and Practice, Second Edition explores the discovery of new macrolide antibiotics, their function, and their clinical use in diseases such as cancer, AIDS, cystic fibrosis and pneumonia. This book discusses the creation of synthetic macrolides and the mechanisms of antibiotic activity. The uses for antimicrobial macrolides in clinical practice are also covered. This book is designed to appeal to both the basic and applied research communities interested in microbiology, bacteriology, and antibiotic/antifungal research and treament.
Jean-Claude Servan-Schreiber enlisted in the French army at the outset of World War II and quickly rose to the rank of lieutenant. Despite his patriotism and courage in defending his country, in which he narrowly escaped death several times, he suffered the bigotry of his fellow soldiers until he was expelled from the army for being Jewish. He sought exile in Spain and was deported and interned in a concentration camp before he managed to join the Allied army in North Africa. He eventually participated in the triumphant liberation of his homeland. His story, almost forgotten, would have remained unknown if not for the efforts of the award-winning and internationally bestselling author Andrei Makine, Retelling Servan-Schreiber's dramatic life with a novelist's skill, he reveals a man who embraced experience in all its joys and sorrows, who knew the pleasures of love amid the savagery of war, and who could forgive the hatred he was subjected to but never forget it. In Servan-Schreiber, who is now nearly a centenarian, Makine celebrates virtues that every citizen should be reminded of: self-sacrifice, honor, love of country, and true heroism.
This text examines organic, physical and materials photochemistry. It reports the first example of a TiO2 sensitization with a fullerene-based donor-acceptor dyad, and covers halophenols, diflusinal photochemistry, hydroxystyrenes, acetylenes, and other related compounds. The volume also investigates whether c,d-alkenes influence the efficiency and course of light-induced reactions, and more.
This book highlights the symmetrical characteristics of organic molecules. It demonstrates how to use principles of symmetry to synthesize and prepare both symmetrical and asymmetrical molecules.
Identifies the polar reactions that are frequently employed in carbogenic synthesis. While touching on retrosynthetic analysis, it's emphasis is on the exploitation and manipulation of the electronic properites of synthons in response to synthetic necessity.
The guiding principle underlying the subject matter specifically compiled in Volume 5 has been to make available to the organic chemical community a sourcebook comprehensively covering all the important &pgr;-bond-dependent transformations. Thermal, photochemical, and metal-catalyzed cycloadditions of every major type are expertly detailed by the most knowledgeable researchers in these areas. The synthetically useful electrocyclic and sigmatropic processes where alkenic centers are intimately involved in the structural change are similarly canvassed in compact detail. With added attention given to ene reactions, small-ring rearrangements, and related transition metal-associated reactions, coverage has been achieved of the full range of organic transformations directly involving the rebonding of alkenic centers. As a consequence, this volume should serve as the comprehensive sourcebook of the field for the next decade and beyond.
Transfusion Medicine offers a concise, clinically focused and practical approach to this important area of medicine. This well-known handbook presents the experience of a world leader in the field of blood banking and transfusion therapy. Transfusion Medicine offers complete guidance on the full range of topics from donor recruitment, blood collection and storage, to testing and transfusing blood components, complications and transmissible diseases, as well as cellular engineering, therapeutic apheresis, and the role of hematopoietic growth factors. This third edition includes updated information on a number of areas including: Current debate on clinical effects of stored red blood cells Emerging infectious diseases and impact on blood safety New concepts of massive transfusion World blood supply Platelet transfusion Pathogen inactivation Transfusion Medicine will be valuable to all those working in the field of blood banking and transfusion. It is a good introduction to transfusion for hematology or oncology fellows and technologists specialising in blood banking.