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More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Of all the different areas in computational chemistry, density functional theory (DFT) enjoys the most rapid development. Even at the level of the local density approximation (LDA), which is computationally less demanding, DFT can usually provide better answers than Hartree-Fock formalism for large systems such as clusters and solids. For atoms and molecules, the results from DFT often rival those obtained by ab initio quantum chemistry, partly because larger basis sets can be used. Such encouraging results have in turn stimulated workers to further investigate the formal theory as well as the computational methodology of DFT.This Part II expands on the methodology and applications of DFT. Some of the chapters report on the latest developments (since the publication of Part I in 1995), while others extend the applications to wider range of molecules and their environments. Together, this and other recent review volumes on DFT show that DFT provides an efficient and accurate alternative to traditional quantum chemical methods. Such demonstration should hopefully stimulate frutiful developments in formal theory, better exchange-correlation functionals, and linear scaling methodology.
School-based food and nutrition education (SFNE) helps schoolchildren and the school community to achieve lasting improvements in their food practices and outlooks; build the capacity to change and to adapt to external change; and pass on their learning to others. SFNE has also an important role in complementing efforts that are being made globally to improve food environments, and in empowering children and adolescents to become active participants in shaping the food system to be better able to deliver healthy and sustainable diets. Despite increasing interest for SFNE, the evidence that supports it and its potential, much of traditional SFNE, particularly in LMICs, is largely underfunded,...
This book has been published by Allenvi (French National Alliance for Environmental Research) to coincide with the 22nd Conference of Parties to the United Nations Framework Convention on Climate Change (COP22) in Marrakesh. It is the outcome of work by academic researchers on both sides of the Mediterranean and provides a remarkable scientific review of the mechanisms of climate change and its impacts on the environment, the economy, health and Mediterranean societies. It will also be valuable in developing responses that draw on “scientific evidence” to address the issues of adaptation, resource conservation, solutions and risk prevention. Reflecting the full complexity of the Mediterranean environment, the book is a major scientific contribution to the climate issue, where various scientific considerations converge to break down the boundaries between disciplines.
"This 176-page report documents nearly 250 "disappearances" during the administration of former President Felipe Calderón, from December 2006 to December 2012. In 149 of those cases, Human Rights Watch found compelling evidence of enforced disappearances, involving the participation of state agents."--Publisher's website.
It is widely recognized that the degree of development of a science is given by the transition from a mainly descriptive stage to a more quantitative stage. In this transition, qualitative interpretations (conceptual models) are complemented with quantification (numerical models, both, deterministic and stochastic). This has been the main task of mathematical geoscientists during the last forty years - to establish new frontiers and new challenges in the study and understanding of the natural world. Mathematics of Planet Earth comprises the proceedings of the International Association for Mathematical Geosciences Conference (IAMG2013), held in Madrid from September 2-6, 2013. The Conference addresses researchers, professionals and students. The proceedings contain more than 150 original contributions and give a multidisciplinary vision of mathematical geosciences.
The Perfect Slime presents the latest state of knowledge and all aspects of the Extracellular Polymeric Substances, (EPS) matrix – from the ecological and health to the antifouling perspectives. The book brings together all the current material in order to expand our understanding of the functions, properties and characteristics of the matrix as well as the possibilities to strengthen or weaken it. The EPS matrix represents the immediate environment in which biofilm organisms live. From their point of view, this matrix has paramount advantages. It allows them to stay together for extended periods and form synergistic microconsortia, it retains extracellular enzymes and turns the matrix int...
Since photosynthetic performance is a fundamental determinant of yield in the vast majority of crops, an understanding of the factors limiting photosynthetic productivity has a crucial role to play in crop improvement programmes. Photosynthesis, unlike the majority of physiological processes in plants, has been the subject of extensive studies at the molecular level for many years. This reductionist approach has resulted in the development of an impressive and detailed understanding of the mechanisms of light capture, energy transduction and carbohydrate biosynthesis, processes that are clearly central to the success of the plant and the productivity of crops. This volume examines in the widest context the factors determining the photosynthetic performance of crops. The emphasis throughout the book is on the setting for photosynthesis rather than the fundamental process itself. The book will prove useful to a wide range of plant scientists, and will encourage a more rapid integration of disciplines in the quest to understand and improve the productivity of crops by the procedures of classical breeding and genetic manipulation.