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The Rise of Virulence and Antibiotic Resistance in Staphylococcus aureus
Staphylococcus aureus S. aureus is a growing issue both within hospitals and community because of its virulence determinants and the continuing emergence of new strains resistant to antimicrobiotics. In this book, we present the state of the art of S. aureus virulence mechanisms and antibiotic-resistance profiles, providing an unprecedented and comprehensive collection of up-to-date research about the evolution, dissemination, and mechanisms of different staphylococcal antimicrobial resistance patterns alongside bacterial virulence determinants and their impact in the medical field. We include several review chapters to allow readers to better understand the mechanisms of methicillin resistance, glycopeptide resistance, and horizontal gene transfer and the effects of alterations in S. aureus membranes and cell walls on drug resistance. In addition, we include chapters dedicated to unveiling S. aureus pathogenicity with the most current research available on S. aureus exfoliative toxins, enterotoxins, surface proteins, biofilm, and defensive responses of S. aureus to antibiotic treatment.
Improving Complex Systems Today
As the main theme of Improving Complex Systems Today implies, this book is intended to provide readers with a new perspective on concurrent engineering from the standpoint of systems engineering. It can serve as a versatile tool to help readers to navigate the ever-changing state of this particular field. The primary focus of concurrent engineering was, at first, on bringing downstream information as far upstream as possible by introducing parallel processing in order to reduce time to market and to prevent errors at a later stage which would sometimes cause irrevocable damage. Up to now, numerous new concepts, methodologies and tools have been developed, but over concurrent engineering’s 20-year history the situation has changed extensively. Now, industry has to work in the global marketplace and to cope with diversifying requirements and increasing complexities. Such globalization and diversification necessitate collaboration across different fields and across national boundaries. Thus, the new concurrent engineering calls for a systems approach to gain global market competitiveness. Improving Complex Systems Today provides a new insight into concurrent engineering today.
Connecting Expertise Multidisciplinary Development For The Future
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New Insights in Leprosy (Hansen's Disease)
Leprosy (or Hansen’s disease) is a chronic infectious granulomatous disease caused by Mycobacterium leprae and Mycobacterium lepromatosis that affects predominantly the skin and peripheral nerves. Leprosy is one of the oldest known illnesses of mankind; however, it is still one of the most neglected diseases worldwide, impacting more than 120 countries, mainly in underdeveloped settings. Early diagnosis and treatment are crucial for reducing the burden of this disease and avoiding long-term irreversible consequences such as deformities and mutilations. Thus, the World Health Organization has focused its efforts on preventive programs as well as the search for easy-to-handle diagnosis tools and the implementation of new strategies to improve the therapeutic options available.
(Im)permanências: História oral, mulheres e envelhecimento na pandemia - Volume 1
(Im)permanências: História oral, mulheres e envelhecimento na pandemia, obra publicada em dois volumes e com a participação de 74 pesquisadoras e pesquisadores de diversas regiões do Brasil, é o resultado da construção coletiva de um acervo de entrevistas de história oral durante a pandemia de Covid-19. São relatos de mulheres plurais sobre seus processos de envelhecimento, que expressam a complexidade e a variedade de suas experiências. Vivências, medos, esperanças, memória e luta conjugam-se em um conjunto singular de testemunhos sobre nosso tempo.
