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Shadow Hunter
One renegade captain threatens disaster HMS Truculent is a nuclear-powered, hunter-killer submarine, and one of the most deadly weapon systems in the world. Phil Hitchens is its distinguished British commander - who has broken away from a NATO exercise and embarked on his own darkly vengeful and deadly mission. Shadowhunter is the codename of the desperate sonar search for HMS Truculent, last seen heading for the Kola Inlet where the cream of Soviet sea power lies unsuspecting at anchor. Shadowhunter is Geoffrey Archer's nail-biting, authentic thriller of undersea battle and international tension - a chillingly credible account of the world brought to the brink of catastrophe.
Safety Pharmacology - Risk Assessment QT Interval Prolongation and Beyond
Current regulatory guidelines for cardiac safety utilize hERG block and QT interval prolongation as risk markers. This strategy has been successful at preventing harmful drugs from being marketed, but criticized for leading to early withdrawal of potentially safe drugs. Here we collected a series of articles presenting new technological and conceptual advances, including refinement of ex vivo and in vitro assays, screens and models, and in silico approaches reflecting the increasing effort that has been put forward by regulatory agencies, industry, and academia to try and address the need of a more accurate, mechanistically-based paradigm of proarrhythmic potential of drugs. This Research Topic is dedicated to the memory of Dr. J. Jeremy Rice, our wonderful friend and colleague.
Translational Vascular Medicine
Translational medicine underpins vascular medicine. It is fundamental to understanding how we treat patients with vascular disease and more importantly, how to prevent it. It is the rationale for drug design and production. Vascular medicine and translational medicine will take over and become the main reason for referring patients to hospital. Therefore, hospital-based clinicians working with basic scientists need to know about translational medicine, which educates and informs them about vascular medicine and how management should be based. This book is a primer for translational vascular medicine and discusses the evolving and exciting areas of basic science applied to vascular medicine. The book is based on the third vascular biology conference held at The Royal College of Physicians in 2008. It provides a large amount of new basic and clinical information and the contributors are world leaders.
American State Papers
Class I. Foreign relations. 6 v. 1st Cong.-20th Cong., 1st sess., April 30, 1789-May 24, 1828.--class II. Indian affairs. 2 v. 1st Cong.-19th Cong., May 25, 1789-March 1, 1827.--class III. Finance. 5 v. 1st Cong.-20th Cong., 1st sess., April 11, 1789-May 16, 1828.--class IV. Commerce and navigation. 2 v. 1st Cong.-17th Cong., April 13, 1789-Feb. 25, 1823.--Class V. Military affairs. 7 v. 1st Cong.-25th Cong., 2d sess., Aug. 10, 1789-March 1, 1838.--class VI. Naval affairs. 4 v. 3d Cong.-24th Cong., 1st sess., Jan 20, 1794-June 15, 1836.--class VII. Post Office department. 1 v. 1st Cong., 2d sess.-22d Cong., Jan. 22, 1790-Feb. 21, 1883.--class VIII. Public lands. 8 v. 1st Cong.-24th Cong., July 1, 1790-Feb. 28, 1837.--class IX. Claims. 1 v. 1st Cong., 2d sess.-17th Cong., Feb. 5, 1790-March 3, 1823.--class X. Miscellaneous. 2 v. 1st Cong.-17th Cong., April 17, 1789-March 3, 1823
Power and Purpose
Not long ago, Paul Ramsey (1913-1988) was a leading voice in North American Christian ethics. Today, however, his intellectual legacy is in question, and his work is largely ignored by current scholars in the field. Against the tide of that neglect, Adam Edward Hollowell argues in Power and Purpose that Ramsey's work can still yield considerable insight for contemporary Christian political theology. Hollowell shows the influences of Jean-Jacques Rousseau and Karl Barth on Ramsey's early work; discusses his conversations with political theologians of his generation, including Reinhold and Richard Niebuhr and Joseph Fletcher; considers his influence on the early virtue theory of Jean Porter an...
Blooming Heart
"Seventeen year old Natalie Garza thought she never had to stress over the hurdles of a typical adolescent life. She believed focusing on school and friendships was everything she needed to help her stay on the right path. Until Andrew, the boy next door, who since the age of six had been one of her closest friends, changed it all. With some persuasion, she reluctantly succumbs to the forces of nature, and ends up on a detour that not only changes their friendship, but sends her on a new path. When their venture to be more than friends fails, a new friendship forms between Natalie and Andrews older brother, Jacob, a nineteen year old college bound young man whos carried a weight on his shoulders since the death of their father. As a bond between Natalie and Jacob grows, she is torn between the remains of her friendship with Andrew and the promise of a lasting relationship with Jacob. Somehow Natalie learns to find some kind of balance, despite the minor complexity she faces when she follows her heart. "
Under Orders
When John Timpson, chairman of the eponymous high street chain, bought his wife Alex a racehorse in 2002, a friend commented that it would be 'a marvellous way to lose money'. Soon they were immersed in a world of trainers' yards, Novice Hurdles and handicaps, and well on the way to proving the old adage that the best way to make a small fortune is to start with a larger one, and buy a few racehorses. As the number of horses increased and Alex became a well-loved figure on the racing scene, John kept a diary of their experiences on and off the track. This witty book describes how racing brought something extra into their marriage – from Mondays at Ludlow to the Cheltenham Festival. It documents the wins, near misses, disappointments and occasional tragedies that make up a racing career – not to mention the friends made, the knowledge gained and the sheer thrill of it all. Under Orders is a joyous and humorous portrait of horseracing in Britain and a tribute to the owners whose dedication and enthusiasm make the whole thing possible. Sales of the book will raise money for the Injured Jockeys Fund.
Cardiac Modeling: Aiming for Optimization of Therapy
This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
