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Concepts and Models for Drug Permeability Studies: Cell and Tissue Based in Vitro Culture Models, Second Edition, summarizes the most important developments in in vitro models for predicting the permeability of drugs. This book is structured around three different approaches, summarizing the most recent achievements regarding models comprising (i) immortalized cells with an intrinsic ability to grow as monolayers when seeded in permeable supports, (ii) primary cells isolated from living organisms and directly cultured as barrier monolayers, and (iii) tissue-based models constructed with cell lines and extracellular matrix that resembles the tridimensional structure of mucosae and other biolo...
Includes Part 1, Number 1: Books and Pamphlets, Including Serials and Contributions to Periodicals (January - June)
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Continental margins and their fossilized analogues are important repositories of natural resources. With better processing techniques and increased availability of high-resolution seismic and potential field data, imaging of present-day continental margins and their embedded sedimentary basins has reached unprecedented levels of refinement and definition, as illustrated by examples described in this volume. This, in turn, has led to greatly improved geological, geodynamic and numerical models for the crustal and mantle processes involved in continental margin formation from the initial stages of rifting through continental rupture and break-up to development of a new ocean basin. Further informing these models, and contributing to a better understanding of the features imaged in the seismic and potential field data, are observations made on fossilized fragments of exhumed subcontinental mantle lithosphere and ocean–continent transition zones preserved in ophiolites and orogenic belts of both Palaeozoic and Mesozoic age from several different continents, including Europe, South Asia and Australasia.
In celebration of the Silver Anniversary of BlackLight Productions Inc. A production company. A creative vision firm. An entertainment brand. Since 1990. Celebrating 25 years of service, this is an artist's view on what happened when he followed his dreams. A quarter of a century look over the career of André C. Allen. Designer. Producer. ArtistPreneur. *A portion of the proceeds go to fund a Summer Technical Theater Training Camp for high school Juniors and Seniors*
Where did your surname come from? Do you know how many people in the United States share it? What does it tell you about your lineage? From the editor of the highly acclaimed Dictionary of Surnames comes the most extensive compilation of surnames in America. The result of 10 years of research and 30 consulting editors, this massive undertaking documents 70,000 surnames of Americans across the country. A reference source like no other, it surveys each surname giving its meaning, nationality, alternate spellings, common forenames associated with it, and the frequency of each surname and forename. The Dictionary of American Family Names is a fascinating journey throughout the multicultural United States, offering a detailed look at the meaning and frequency of surnames throughout the country. For students studying family genealogy, others interested in finding out more about their own lineage, or lexicographers, the Dictionary is an ideal place to begin research.
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