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Endoplasmic Reticulum
The purpose of this book is to concentrate on recent developments on endoplasmic reticulum. The articles collected in this book are contributions by invited researchers with a long-standing experience in different research areas. We hope that the material presented here is understandable to a broad audience, not only scientists but also people with general background in many different biological sciences. This volume offers you up-to-date, expert reviews of the fast-moving field of endoplasmic reticulum. The book is divided in two sections: 1. Introduction and 2. Endoplasmic Reticulum Properties and Functions.
Neurodevelopment and Neurodevelopmental Disorder
Nowadays, neurodevelopmental disorders comprise a large proportion of mental health diagnoses. These disorders, according to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition, include intellectual disabilities, communication disorders, autism spectrum disorders, attention deficit hyperactivity disorders, specific learning disorders, and motor disorders. Current research is pointing in the direction of schizophrenia, bipolar disorders, and other disorders being included in the category of neurodevelopmental disorders as well. There is a great deal of overlap among these disorders and they are best understood in a dimensional fashion. This book sets out the future of psychiatry in relation to these disorders and what is basically a new understanding of psychiatry in recent decades. Chapters cover topics such as early recognition of schizophrenia, epilepsy, and the genetics of ataxia telangiectasia. Also included is an examination of the complex issue of systems biology and neurodevelopment.
Melatonin
This book, on the pineal hormone melatonin, is addressed to a wide non-cognizant and cognizant readership. The hormone appears to be involved in sleep onset and other functions associated with the body’s clock, the suprachiasmic nucleus. It is ubiquitous throughout both the animal and plant kingdoms and has a long evolutionary history as a hormone. Melatonin has a major role in the regulation of circadian rhythms in non-mammalian vertebrates and forms part of their control in mammals. The present text emphasizes the positive role of exogenously administered melatonin, and its synthetic derivatives, on disrupted circadian rhythm-related dysfunctions. This is effected by resetting the clock in jet lag sufferers and those with seasonal affective disorders, insomnia, and various neurological conditions.
Biophysical Chemistry
Biophysical chemistry is one of the most interesting interdisciplinary research fields. Some of its different subjects have been intensively studied for decades. Now the field attracts not only scientists from chemistry, physics, and biology backgrounds but also those from medicine, pharmacy, and other sciences. We aimed to start this version of the book Biophysical Chemistry from advanced principles, as we include some of the most advanced subject matter, such as advanced topics in catalysis applications (first section) and therapeutic applications (second section). This led us to limit our selection to only chapters with high standards, therefore there are only six chapters, divided into two sections. We have assumed that the interested readers are familiar with the fundamentals of some advanced topics in mathematics such as integration, differentiation, and calculus and have some knowledge of organic and physical chemistry, biology, and pharmacy. We hope that the book will be valuable to graduate and postdoctoral students with the requisite background, and by some advanced researchers active in chemistry, biology, biochemistry, medicine, pharmacy, and other sciences.
Mechanisms and Management of Senescence
Senescence represents a complex universal phenomenon that can be impacted by several factors. It is emerging as a therapeutic target for several diseases. This book presents an overview of the current mechanisms and management of senescence in humans. It also provides comparative data on senescence in animals and plants.
Antioxidants
Antioxidants are substances that can prevent or slow damage to living cells caused by free radicals, which are unstable molecules the body produces as a reaction to environmental and other pressures. Sometimes called “free-radical scavengers,” free radicals can cause mutation in different biological compounds such as protein, nucleic acids, and lipids, which lead to various diseases (cancer, cardiovascular disease, aging, etc.). Healthy foods are considered a main source of antioxidant compounds and from the beginning of a person’s life, a strong relationship is seen between antioxidant compounds and the prevention of certain diseases, such as types of inflammations, cardiovascular diseases, and different kinds of cancers. It is thus of great importance that new data relating to antioxidants and their biological activity be collected and that antioxidant modes of action be illustrated.Experts from around the world contributed to the current book, discussing antioxidant sources, modes of action, and their relation to human diseases. Twenty-five chapters are presented in two sections: Antioxidants: Sources and Modes of Action and Antioxidants Compounds and Diseases.
Tumor Progression and Metastasis
This book offers significant coverage on different aspects of cancer from risk factors to the mechanisms leading to tumor progression and metastasis. Although tremendous progress has been made in cancer research and treatment, cancer metastasis remains a major unmet clinical need. The life and death of many cancer patients hangs on the degree of metastasis. This book provides new perspectives for diagnosis and cancer therapy. It includes new technologies and a new basis for current cancer therapies. To guarantee the high quality of this book, important topics are included and rigorously discussed in a simple and authentic way. The book addresses important challenges governing tumor progression and metastasis and brings new responses to both diagnosis and therapy. This book is a great source of knowledge and will be useful for researchers, medical doctors, oncologists, graduate and medical students, continued medical educators, health care providers, and all individuals interested in understanding cancer and its challenges.
Cell Communication and Signaling in Health and Disease
Cell communication and signaling are essential functions for life. The topic encompasses all basic and translational aspects of cellular communication and signaling pathways in normal and pathological conditions. Many diseases are the result of dysfunction in cell communication and signaling. This book presents contributions ranging from studies of sensory transduction, membrane receptors, ion channels, protein modification, cell transformation, receptor internalization, and trafficking to disease-oriented studies focusing on neurodegenerative diseases or cancer. As such, the book will provide a gateway for newly interested investigators and serve as a resource for seasoned researchers of cell biological phenomena in health and disease. Targeted at students and researchers in biological, medical, and chemical disciplines, this book will provide an overview of the work that is being done on this cell biology topic. The book highlights any gaps and areas that would benefit from further exploration pertaining to both intracellular and intercellular cell communication and signaling. In addition, the book will contribute to the training of current and future cell biologists.
Extracellular Vesicles
This edited volume, Extracellular Vesicles - Applications and Therapeutic Potential, provides a comprehensive overview of the emerging data confirming the involvement of extracellular vesicles (EVs) in disease development. It also discusses the scientific advancements that have enabled the characterization and manipulation of EVs, leading to their utilization as tools in biomarker discovery, disease diagnosis, prognosis, and therapeutic interventions. The book examines the latest research efforts in the field by international authors and opens new possible research paths for further novel developments.
