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Migration and the Origins of the English Atlantic World
England's seventeenth-century colonial empire in North America and the Caribbean was created by migration. The quickening pace of this essential migration is captured in the London port register of 1635, the largest extant port register for any single year in the colonial period and unique in its record of migration to America and to the European continent. Alison Games analyzes the 7,500 people who traveled from London in that year, recreating individual careers, exploring colonial societies at a time of emerging viability, and delineating a world sustained and defined by migration. The colonial travelers were bound for the major regions of English settlement -- New England, the Chesapeake,...
Regenerative Medicine and Tissue Engineering
Tissue Engineering may offer new treatment alternatives for organ replacement or repair deteriorated organs. Among the clinical applications of Tissue Engineering are the production of artificial skin for burn patients, tissue engineered trachea, cartilage for knee-replacement procedures, urinary bladder replacement, urethra substitutes and cellular therapies for the treatment of urinary incontinence. The Tissue Engineering approach has major advantages over traditional organ transplantation and circumvents the problem of organ shortage. Tissues reconstructed from readily available biopsy material induce only minimal or no immunogenicity when reimplanted in the patient. This book is aimed at anyone interested in the application of Tissue Engineering in different organ systems. It offers insights into a wide variety of strategies applying the principles of Tissue Engineering to tissue and organ regeneration.
Defining the Spatial Organization of Immune Responses to Cancer and Viruses in situ
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Focus on Malignant Pleural Mesothelioma Immunology and Immunotherapy
Malignant pleural mesothelioma (MPM) is a rare thoracic cancer that derives from the mesothelial cells of the pleura and is causally associated with exposure to asbestos. Because of its aggressiveness and resistance to therapies, MPM prognosis is extremely poor and the 5-year survival rate is approximately 10%. Despite its poor effectiveness, chemotherapy with cisplatin and pemetrexed has long remained the standard-of-care for upfront treatment with no second line therapy available. Recently, the approval of ipilimumab (anti-CTLA-4) plus nivolumab (anti-PD-1) for the first-line treatment of unresectable MPM has marked a significant milestone, in particular for the non-epithelioid MPM subtype...
British Conservatism and the Legal Regulation of Intimate Relationships
What does conservatism, as a body of political thought, say about the legal regulation of intimate relationships, and to what extent has this thought influenced the Conservative Party's approach to family law? With this question as its focus, this book explores the relationship between family law, conservatism and the Conservative Party since the 1980s. Taking a politico- and socio-legal perspective, the discussion draws on an expansive reading of Hansard as well as recently released archival material. The study first sets out the political tradition of conservatism, relying largely on the work of Edmund Burke, before going on to analyse the discourse around the development of four crucial statutes in the field, namely: the Matrimonial and Family Proceedings Act 1984; the Family Law Act 1996; the Civil Partnership Act 2004; and the Marriage (Same Sex Couples) Act 2013. This work offers the first extended synthesis of family law, conservative political thought and Conservative Party politics, and as such provides significant new insight into how family law is made. Runner up of the 2020 PSA Conservatism Studies Book Prize.
Magnesium Alloys for Biomedical Applications
Magnesium alloys have enormous potential for use in biomedical implants. Magnesium Alloys for Biomedical Applications delves into recent advances and prospects for implementation and provides scientific insights into current issues posed by Mg alloy materials. It provides an overview of research on their mechanical and tribological characteristics, corrosion tendencies, and biological characteristics, with a particular emphasis on biomedical implants. Details the fundamentals of Mg alloys as well as necessary surface modifications of Mg alloys for biomedical use. Discusses emerging Mg alloys and their composites. Covers mechanical, tribological, and chemical properties, as well as fatigue an...
