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Atypical Diabetes
Although the vast majority of diabetes cases (type 1 and type 2) are polygenic diseases, research, funded by the American Diabetes Association, has found that some forms of diabetes, distinct from type 1 or type 2 diabetes, are caused by single gene mutations. It has been estimated that these monogenic forms of diabetes account for up to five percent of all diabetes cases. In addition to monogenic diabetes, there are other atypical causes of diabetes, including: genetic defects in insulin action; diseases of the exocrine pancreas; and endocrinopathies. Given recent advances in our understanding of sub-types of diabetes, the time has come for a book on how to correctly diagnose and treat patients with atypical forms of this disorder. The book will be divided into three parts, each exploring distinct categories of atypical diabetes. Part I: Monogenic Diabetes: Genetic Defects of β-cell development and function; Part II: Insulin resistance, genetic defects in insulin action, and diseases of exocrine pancreas; Part III: Endocrinopathies, Immune-mediated diabetes, Diabetes of Unknown cause, and Other genetic syndromes sometimes associated with diabetes.
Regulating Public Services
This book provides the tools needed to analyse the present and the future of economic regulation.
Clinical Perspectives and Targeted Therapies in Apoptosis
Clinical Perspectives and Targeted Therapies in Apoptosis: Drug Discovery, Drug Delivery, and Disease Prevention provides comprehensive coverage, from basic cell biology, to modern assessment techniques for apoptosis in all major disease areas. Chapters provide an introduction to the fundamentals of cell biology, biochemical mechanisms, and the pathophysiological consequences of apoptosis. In addition, the book covers the tools and techniques used to quantify apoptosis and the significance of apoptosis in drug discovery, drug delivery, and its applications in disease prevention. Finally, the book provides a comprehensive compilation of the apoptosis targeting drugs that recently underwent clinical trials. This combination of fundamentals, along with applications in drug discovery, drug delivery, and clinical research make this book a useful resource for those in both academia and industry who are engaged in pharmaceutical, biomedical and biotechnology research.
Flying Off Course
Aviation is one of the most widely talked about industries in the global economy and yet airlines continue to present an enigma. Between 2010 and 2018 the global airline industry experienced its longest period of sustained profitability; however, huge global profits hid a darker side. Many airlines made inadequate profits or serious losses while others collapsed entirely. This fifth edition of Flying Off Course explains why. Written by leading industry expert, Rigas Doganis, this book is an indispensable guide to the inner workings of this exciting industry. Providing a complete, practical introduction to the fundamentals of airline economics and marketing, it explores the structure of the m...
The Tunisian Labor Market in an Era of Transition
This book offers a comprehensive examination of the key labor market issues facing Tunisia, including the size, structure, and evolution of the labor force, employment and unemployment, wage formation, gender differences, education, and migration.
Mechanisms of Insulin Action
More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
The Car That Knew Too Much
The inside story of the groundbreaking experiment that captured what people think about the life-and-death dilemmas posed by driverless cars. Human drivers don't find themselves facing such moral dilemmas as "should I sacrifice myself by driving off a cliff if that could save the life of a little girl on the road?" Human brains aren't fast enough to make that kind of calculation; the car is over the cliff in a nanosecond. A self-driving car, on the other hand, can compute fast enough to make such a decision--to do whatever humans have programmed it to do. But what should that be? This book investigates how people want driverless cars to decide matters of life and death. In The Car That Knew ...
Crony Capitalism in the Middle East
This volume provides new perspectives on crony capitalism in the Middle East. It draws on rich empirical information on the activities of political connected firms in the economy and their impact on private sector development in the region.
