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The Identification of the CF (Cystic Fibrosis) Gene
Proceedings of an international workshop held in Sestri Levante (Genoa), Italy, April 9--11, 1990
Pseudomonas Aeruginosa, Biology, Genetics, and Host-pathogen Interactions
The opportunistic pathogen Pseudomonas aeruginosa offers a rich variety of biologically relevant topics to explore and serves as a model system to understand the interactions of Gram-negative bacteria with human hosts. The organism adapts readily to most environments. It has a large and variable genome with a great deal of metabolic potential. P. aeruginosa encodes a variety of regulatory systems to fine tune gene expression and integrate environmental signals. This organism can infect both plants and animals and produces a plethora of enzymes and factors that can overcome host defenses. Moreover, it has the ability to change between the states of a sedentary colonizer to an invasive and hig...
Microbial Surfactants
Biosurfactants are surface-active biomolecules produced by a wide variety of microorganisms. They can be produced from renewable sources, and possess high surface activity, high specificity, low toxicity, tolerance to pH, temperature and ionic strength, biodegradability, excellent emulsifying and demulsifying ability and antimicrobial activity. Biosurfactants have found applications in several industries including organic chemicals, petrochemicals, mining, metallurgy (mainly bioleaching), agrochemicals, fertilizers, foods, beverages, cosmetics, pharmaceuticals and many others. The main aim of this volume is to highlight concepts, classifications, production and applications of microbial surf...
Bacterial Genomes
A wide range of microbiologists, molecular biologists, and molecular evolutionary biologists will find this new volume of singular interest. It summarizes the present knowledge about the structure and stability of microbial genomes, and reviews the techniques used to analyze and fingerprint them. Maps of approximately thirty important microbes, along with articles on the construction and relevant features of the maps are included. The volume is not intended as a complete compendium of all information on microbial genomes, but rather focuses on approaches, methods and good examples of the analysis of small genomes.
Pseudomonas aeruginosa
This book covers the wide set of well-regulated virulence factors and defense mechanisms of Pseudomonas aeruginosa focusing on stress responses and the evolution of this opportunistic human pathogen. Pseudomonas aeruginosa is responsible for one out of ten hospital infections. Additionally, this Gram-negative bacterium is accountable for persistent infections in immunocompromised individuals and the leading cause of chronic lung infections in cystic fibrosis patients. This book provides insight on the metabolic versatility of Pseudomonas aeruginosa and its mechanisms for biofilm formation that make this organism highly efficient in causing infections. The book invites the readers to learn mo...
Antimicrobial Resistance of the Human Eye
The book covers antimicrobial resistance in ocular diseases, including the microbiology of the ocular surface, the history and origin of antimicrobials, methods to detect antimicrobial resistance and antimicrobial resistance genes, and the impact of antimicrobial resistance on a variety of ocular diseases. The inclusion of chapters covers bacterial keratitis, fungal keratitis, viral keratitis, acanthamoeba keratitis, endophthalmitis, dry eye disease, post fever retinitis, and uveitis including management and prevention of antimicrobial resistance. Key Features: Focusses on various ocular diseases and their association with antimicrobial resistance; Includes data relevant to drug industry to develop drugs for specific ophthalmic use; Illustrates ocular surface microbiome under various diseased condition;s Highlights the microbes associated with the conjunctiva and cornea of the human eye; Enumerates the changes in the abundance and diversity of the antimicrobial resistant (AMR) microorganisms in the diseased eye. This book is aimed at professionals and researchers in ophthalmology, microbiologists, infectious disease specialists, and public health.
Nonmammalian Genomic Analysis
Offering detailed protocols for those needing to construct a variety of maps and isolate genes, this unique book is intended to popularize the new techniques of genome analysis derived from the Human Genome Project. The power of these new methods is often most striking when applied to problems outside of human genetics, particularly the nonmammalian systems on which many researchers focus. Many of these organisms are economically important and biologically rich.Nonmammalian Genomic Analysis: A Practical Guide covers the "how to" aspects of preparation, handling, cloning, and analysis of large DNA and the creation of chromosome and genome maps. This lab manual facilitates the transfer of thes...
Pseudomonas
Pseudomonas comprises three volumes covering the biology of pseudomonads in a wide context, including the niches they inhabit, the taxonomic relations among members of this group, the molecular biology of gene expression in different niches and under different environmental conditions, the analysis of virulence traits in plants, animals and human pathogens as well as the determinants that make some strains useful for biotechnological applications and promotion of plant growth. There has been growing interest in pseudomonads and a particular urge to understand the biology underlying the complex metabolism of these ubiquitous microbes. These bacteria are capable of colonizing a wide range of n...
Cystic Fibrosis
Cystic fibrosis (CF) is one of the most common fatal hereditary diseases. The discovery of the cystic fibrosis transmembrane conductance regulator (CFTR) gene 25 years ago set the stage for unraveling the pathogenesis of CF lung disease, continuous refinement of symptomatic treatments and the development of mutation-specific therapies, which are now becoming available for a subgroup of patients. This ERS Monograph provides an update on all aspects of CF lung disease, from infancy to adulthood, including current concepts on disease process, improvements in early diagnosis and monitoring, therapeutic approaches, and patient care. The book highlights important recent developments and discusses the next steps that will be required for further improvement of the life expectancy and quality of life of CF patients. It will be an essential reference for basic and clinical scientists and all members of the CF team.
