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Approaches to Advance Cancer Vaccines to Clinical Utility
Although cancer vaccines have yielded promising results both in vitro and in animal models, their translation into clinical application has not been very successful so far. Through the success of immune checkpoint inhibitors, the tumor immunotherapy field revived and led to important new insights. A better understanding of the functional capacity of different dendritic cell (DC) subsets and the immunogenicity of tumor antigens, more particularly of neoantigens, have important implications for the improvement of cancer vaccines. These insights can guide the development of novel strategies, to enhance the clinical utility of cancer vaccines. The aim of this Research Topic is therefore to provide a comprehensive overview of current issues regarding cancer vaccine development with an emphasis on novel approaches toward enhancing their efficacy.
AACR 2016: Abstracts 2697-5293
The AACR Annual Meeting is a must-attend event for cancer researchers and the broader cancer community. This year's theme, "Delivering Cures Through Cancer Science," reinforces the inextricable link between research and advances in patient care. The theme will be evident throughout the meeting as the latest, most exciting discoveries are presented in every area of cancer research. There will be a number of presentations that include exciting new data from cutting-edge clinical trials as well as companion presentations that spotlight the science behind the trials and implications for delivering improved care to patients. This book contains abstracts 2697-5293 presented on April 19-20, 2016, at the AACR Annual Meeting.
Social life in old New Orleans
“Children should be seen and not heard.” Children were neither seen nor heard in the days of which I write, the days of 1840. They led the simple life, going and coming in their own unobtrusive way, making no stir in fashionable circles, with laces and flounces and feathered hats. There were no ready-made garments then for grown-ups, much less for children. It was before California gold mines, before the Mexican war, before money was so abundant that we children could turn up our little noses at a picayune. I recall the time when Alfred Munroe descended from Boston upon the mercantile world of New Orleans, and opened on Camp Street a “one price” clothing store for men. Nobody had ever heard of one price, and no deviation, for anything, from a chicken to a plantation. The fun of hectoring over price, and feeling, no matter how the trade ended, you had a bargain after all, was denied the customers of Mr. Alfred Munroe. The innovation was startling, but Munroe retired with a fortune in course of time.
Men of Mark
TO PRESUME to multiply books in this day of excellent writers and learned book-makers is a rash thing perhaps for a novice. It may even be a presumption that shall be met by the production itself being driven from the market by the keen, searching criticism of not only the reviewers, but less noted objectors. And yet there are books that meet a ready sale because they seem like "Ishmaelites"--against everybody and everybody against them. Whether this work shall ever accomplish the design of the author may not at all be determined by its sale. While I hope to secure some pecuniary gain that I may accompany it with a companion illustrating what our women have done, yet by no means do I send it...
