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Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.
Cancer, a global health crisis, is projected by WHO to cause 10 million deaths by 2020, with a mortality rate of one in six. This has spurred intensive research for innovative treatments. Cancer arises from genetic abnormalities triggering uncontrolled cell division, presenting distinct hallmarks. Both inherited and acquired mutations transform cell behavior, resulting in abnormal growth, reproduction, and death. Environmental toxins and spontaneous mutations contribute to genetic changes, while hereditary factors predispose some individuals. Despite rapid advancements in targeted treatments and immunotherapy, therapy resistance remains a formidable challenge due to the disease's heterogeneity. Understanding cancer biology is crucial for developing effective treatments. This book provides a comprehensive overview, covering basic cell biology, genetics, cancer development mechanisms, immune system involvement, diagnostic methods, treatment modalities, including emerging therapies, and challenges like drug resistance. Geared towards students and researchers in biology, medicine, and oncology, it offers vital insights into combating this complex disease.
This volume provides a practical, comprehensive overview on benign and malignant disease of the adult kidney. The text addresses the topic of assessment and management of patients with surgical renal disease. Within this scope, it includes hereditary and spontaneous renal neoplasms, as well as non-neoplastic disease that manifests as a clinically relevant mass. The book is organized into chapters focusing on discrete disease entities and incorporating pathology, surgical management, oncologic therapy, radiologic findings, and molecular alterations. This text is designed to address relevant areas of clinical management of renal neoplastic and non-neoplastic disease across multiple specialties and levels of training. Written by experts in the field, The Kidney: A Comprehensive Guide to Pathologic Diagnosis and Management is a valuable resource on the diagnosis and management of patients with not only renal cell carcinoma, but also other renal processes that require surgical intervention.
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In this issue of Surgical Pathology Clinics, guest editor Dr. Ming Zhou brings his considerable expertise to the topic of Genitourinary Pathology. Top experts in the field cover key topics such as prostate cancer: update on grading and reporting; cribriform lesions of the prostate; urothelial carcinoma: divergent differentiation and variants; kidney tumors: new developments in existing WHO kidney tumor entities; and more. - Contains 13 relevant, practice-oriented topics including testicular tumors: new developments in germ cell tumors and sex cord stromal tumors; computational pathology in genitourinary pathology; molecular genetics of prostate cancer and role of genomic testing; evolving role of multiparametric MRI in prostate cancer diagnosis and reporting; and more. - Provides in-depth clinical reviews on current topics in genitourinary pathology, offering actionable insights for clinical practice. - Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.
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This book serves as a practical guide and provides updates in Genitourinary (GU) Pathology. By using a “Questions and Answers” format, it addresses frequently encountered diagnostic challenges in daily practice for pathologists. Emphasis is placed on diagnosis and differential diagnosis based on morphological characteristics, clinicopathologic correlation, and interpretation of immunohistochemical and other ancillary tests. Concise answers to each question are provided by experts in the field accompanied by ample high quality illustrations and updated references. This book includes common and rare benign and malignant conditions in the GU system, covering the entire genitourinary system including the prostate, kidney, bladder, testis, urethra, ureter, penis and adrenal. It also reviews current topics, controversies and diagnostic dilemmas in diagnostic GU pathology. Practical Genitourinary Pathology serves as a quick reference for busy practicing pathologists, pathologists in training, urologists, medical students, and other physicians with questions of genitourinary conditions.