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Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery
Bioceramics play an important role in repairing and regenerating defective or damaged bone. Annually, more than 500,000 bone graft procedures are performed in the United States and approximately 2.2 million are conducted worldwide. Advanced Bioactive Inorganic Materials for Bone Regeneration and Drug Delivery reviews the latest advances in the field of bioceramics. The book summarizes innovative concepts, bioceramic design, and methods for material synthesis and drug delivery. Offering guidance for biomedical engineering researchers and material scientists, the book explores: Novel mesoporous bioactive glasses and silicate-based ceramics for bone regeneration and drug delivery Bioactive sili...
Bioactive Materials for Soft Tissue Regeneration
This is a follow up of the authors' previous book entitled "Bioactive materials for bone regeneration. Generally speaking, human tissue can be classified as hard tissue such as bone and soft tissue such as skin, mussel, tendon, blood vessel, nerve etc. and including important organs such as heart, liver, lung. Regenerative medicine is dealing with both hard tissue and soft tissue regeneration and is one of the most important part of the modern medicine with significant clinical needs including general surgery, plastic surgery, burn and wound healing, cardiovascular disease treatments. Based on the authors' previous research and review of the international advances in hard tissue regeneration...
The Immune Response to Implanted Materials and Devices
This book provides a comprehensive overview of the cascade of events activated in the body following the implant of biomaterials and devices. It is one of the first books to shed light on the role of the host immune response on therapeutic efficacy, and reviews the state-of-the-art for both basic science and medical applications. The text examines advantages and disadvantages of the use of synthetic versus natural biomaterials. Particular emphasis is placed on the role of biomimicry in the development of smart strategies able to modulate infiltrating immune cells, thus reducing side effects (such as acute and chronic inflammation, fibrosis and/or implant rejection) and improving the therapeu...
Magnesium Alloys for Biomedical Applications
Magnesium alloys have enormous potential for use in biomedical implants. Magnesium Alloys for Biomedical Applications delves into recent advances and prospects for implementation and provides scientific insights into current issues posed by Mg alloy materials. It provides an overview of research on their mechanical and tribological characteristics, corrosion tendencies, and biological characteristics, with a particular emphasis on biomedical implants. Details the fundamentals of Mg alloys as well as necessary surface modifications of Mg alloys for biomedical use. Discusses emerging Mg alloys and their composites. Covers mechanical, tribological, and chemical properties, as well as fatigue an...
Hierarchically structured biomaterials for tissue regeneration
Repairing tissue defects caused by diseases and traumas presents significant challenges in the clinic. Recent advancements in biomaterials have offered promising strategies for promoting tissue regeneration. In particular, the exploration of 3D macro and microstructures of biomaterials has proven crucial in this process. The integration of macro, micro, and nanostructures facilitates the performance of biomaterials in terms of their mechanical properties, degradation rate, and distinctive impacts on cellular activities. In this review, we summarize the recent progress in biomaterials with hierarchical structures for tissue regeneration. We explore the various methods and strategies employed ...
Advanced Porous Biomaterials for Drug Delivery Applications
Advanced Porous Biomaterials for Drug Delivery Applications probes cutting-edge progress in the application of advanced porous biomaterials in drug delivery fields. These biomaterials offer promise in improving upon the design, cost, and creation of potent novel drug delivery systems. The book focuses on two categories: nature engineered and synthetic advanced porous biomaterials, with a wide range of low-cost porous biomaterial-based systems that have been used for the delivery of diverse drugs through in vitro/in vivo approaches. Details how advanced porous biomaterial-assisted systems improve essential properties in drug delivery applications Explains how advanced porous biomaterials syst...
Developments and Applications of Calcium Phosphate Bone Cements
This book presents a state-of-the-art review of the latest advances in developing calcium- phosphate bone cements and their applications. It covers the synthesis methods, characterization approaches, material modification and novel binders, as well as the fabrication technologies of calcium-phosphate-based biomaterials in regenerative medicine and their clinical applications. It also highlights methodologies for fabricating scaffolds, biofunctional surfaces/interfaces and subsequently modulating the host response to implantable/injectable materials, and integrates a series of discussions and insights into calcium-phosphate cements and constructs in bone regenerative medicine. As such, the book not only covers the fundamentals but also opens new avenues for meeting future challenges in research and clinical applications.
Biofabrication for Orthopedics
Biofabrication for Orthopedics A comprehensive overview of biofabrication techniques for orthopedics and their novel applications With an ever-increasing global population and the rise in the occurrence of orthopedic diseases amongst an aging population, it is essential for technological advances to meet this growing medical need. Orthopedic biofabrication is a cutting-edge field that seeks to produce novel clinical solutions to this mounting problem, through the incorporation of revolutionary technologies that have the potential to not only transform healthcare, but also provide highly automated and personalized patient solutions. With the advances in the discipline, there is a significant ...
Biomaterials Science and Engineering
These contribution books collect reviews and original articles from eminent experts working in the interdisciplinary arena of biomaterial development and use. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentials of different synthetic and engineered biomaterials. Contributions were not selected based on a direct market or clinical interest, than on results coming from very fundamental studies which have been mainly gathered for this book. This fact will also allow to gain a more general view of what and how the various biomaterials can do and work for, along with the methodologies necessary to design, develop and characterize them, without the restrictions necessarily imposed by industrial or profit concerns. The book collects 22 chapters related to recent researches on new materials, particularly dealing with their potential and different applications in biomedicine and clinics: from tissue engineering to polymeric scaffolds, from bone mimetic products to prostheses, up to strategies to manage their interaction with living cells.
Bioactive Materials for Bone Regeneration
Bioactive Materials for Bone Regeneration summarizes research advances on the topic, including sections on the characteristics of biomaterial-induced microenvironments, interactions of bioactive materials with stem cells and tissues, and the immunomodulatory microenvironment induced by biomaterials and its effects on osteogenesis. As the regeneration of large-size bone tissue defects represents a significant clinical challenge, this book demonstrates how new biomaterials with specific chemical and physical characteristics may interact with the host and create a unique micro-environment that actively facilitates stem cell differentiation along a specific lineage, thus stimulating tissue regeneration. - Provides readers with the latest research developments in the fabrication techniques of bioactive materials for tissue regeneration and tissue engineering applications - Presents the latest research advancements on how bioactive materials interact with the host and induce micro-environments for stem cell differentiation, immunomodulation and tissue regeneration - Covers the methods, strategies, principle and mechanisms on constructing beneficial biomaterial microenvironments
