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Debating Environmental Regimes
A consistently high-profile issue, oversight of earth's resources and environment is important to all people. The debate rages, pitting the needs of business against the desires of environmentalists. Although numerous summits have occurred to formulate international policy on this topic, a solution has proven elusive. This book compiles a selection of articles studying the implications of such summits and the importance of environmental regulation in general.
Quantum Cosmology
Consequences of quantum gravity on grander scales are expected to be enormous: only such a theory can show how black holes really behave and where our universe came from. Applications of loop quantum gravity to cosmology have especially by now shed much light on cosmic evolution of a universe in a fundamental, microscopic description. Modern techniques are explained in this book which demonstrate how the universe could have come from a non-singular phase before the big bang, how equations for the evolution of structure can be derived, but also what fundamental limitations remain to our knowledge of the universe before the big bang. The following topics will be covered in this book: Hamiltoni...
The Pharmacology of Alcohol and Alcohol Dependence
This is a comprehensive review of the pharmacological effects of alcohol and the mechanisms underlying the pathogenesis of alcoholism. The book draws on general pharmacology, neuropharmacology, and alcohol studies to explore its theme. The second volume in the ALCOHOL AND ALCOHOLISM series, it focuses on the pharmacologic mechanisms underlying the development of alcoholism. The first section on basic pharmacology is concerned with those aspects that are common to all of alcohol's effects. These include pharmacokinetics, general metabolism, and cross-tolerance. The second section on neuropharmacology describes the effects of alcohol on various brain functions, including circulation and metabolism. The third section provides an in-depth review of the neurobiology of physical dependence, withdrawal, and physiological tolerance. The book as a whole gives a comprehensive and authoritative picture of the complex pharmacologic actions of alcohol, particularly on the nervous system. For clinicians and researchers in the field of alcohol and alcoholism, it will serve as a fundamental reference.
A Clinician's Pearls & Myths in Rheumatology
Important strides have been made in understanding the pathophysiologic basis of many inflammatory conditions in recent years, but rheumatology remains a discipline in which diagnosis is rooted in the medical history skillfully extracted from the patient, the careful physical examination, and the discriminating use of laboratory tests and imaging. Moreover, selection of the most appropriate therapy for patients with rheumatic diseases also remains heavily reliant upon clinical experience. Medical disciplines such as rheumatology that depend significantly upon clinical wisdom are prone to the development of systems of ‘Pearls’ and ‘Myths,’ related to the diseases they call their own, a ‘Pearl’ being a nugget of truth about the diagnosis or treatment of a particular disease that has been gained by dint of clinical experience and a ‘Myth’ being a commonly held belief that influences the practice of many clinicians – but is false. This book will pool together the clinical wisdom of seasoned, expert rheumatologists who participate in the care of patients with autoimmune diseases, systemic inflammatory disorders, and all other rheumatic conditions.
Biological Effects of Alcohol
The disease of alcoholism has long been a major health problem which affects significant proportions of the populations of various countries. It is now apparent that legal and moral sanctions have not provided a sufficient impetus to arrest this rampant problem. Therefore, it is evident that the approach to this international health problem must rely on the development of efficacious prevention and treatment techniques. If the treatment and prevention of alcoholism is to be based on the rational assessment of the disease, it is imperative that we understand the complex determinants of this disease. The elements that initiate and perpetuate this addictive process must be examined and elucidat...
The Autoimmune Diseases
The Autoimmune Diseases, Sixth Edition, emphasizes the "3 P's" of 21st Century medicine: precision, prediction and prevention. Topics cover the modern systems approach to biology that involves large amounts of personalized, ongoing physiologic data ("omics") coupled with advanced methods of analysis, new tests of genetic engineering, such as CRISPR, auto inflammatory diseases, autoimmune responses to tumor immunotherapy, and information on normal immune response and disorders. Each of the major autoimmune disorders is discussed by researchers and clinical investigators experienced in dealing with patients. Chapters emphasize the immunologic basis of the disease as well as the use of immunolo...
Party System in India
India’s party system has been under flux, transformation and reconfiguration since the end of the 1980s. By the time the sun set on the twentieth century, the party system in India had developed a plurality of national and regional levels and following several experiences in fits and starts, coalition making among the parties too stabilized at the national level. The dawn of twenty first century thus witnessed a federalized party system in place, where coalition making and cohabitation amongst the parties stabilized at both national and regional levels. As a result, since 1999 India has had two completing governments completing their full term at the national level; the third, UPA II, has ...
Blood
This book examines both the fluid and cellular components of blood. After the introductory section, the second section presents updates on various topics in hemodynamics. Chapters in this section discuss anemia, 4D flow MRI in cardiology, cardiovascular complications of robot-assisted laparoscopic pelvic surgery, altered perfusion in multiple sclerosis, and hemodynamic laminar shear stress in oxidative homeostasis. The third section focuses on thalassemia with chapters on diagnosis and screening for thalassemia, high blood pressure in beta-thalassemia, and hepatitis C infection in thalassemia patients.
Free Radicals in Human Health and Disease
The role of oxidative stress in human disease has become an area of intense interest. Free radicals, a normal product of metabolism, exist in all aerobic cells in balance with biochemical antioxidants. Environmental stress increases the levels of free radicals drastically, thereby disturbing the equilibrium between free radical production and the antioxidant capability causing oxidative stress. Over the years, ROS has been implicated in the pathologies of various diseases like cancer, neurological disorder, cardiovascular diseases rheumatoid arthritis, diabetes etc. This book provides an in depth critical state-of-art reviews from established investigators on free radicals, ROS associated pa...
