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Radiobiological Modelling in Radiation Oncology
The move towards individually-optimised treatments, using knowledge of normal tissue and tumour radiosensitivity, proliferation rates, etc, in combination with three-dimensional planning, will need mathematical modelling to achieve its full potential. This modelling process will also be capable of helping develop a rational and cost-effective use of resources.Amongst radiation oncologists and medical physicists there is a need for a greater understanding of the scope, applications and limitations of radiobiological modelling, particularly in complex situations that include multiple treatment variables, the respective influence of which are difficult to separate out by randomised trials without using radiobiologically-based analysis.In future there will be increasing use of modelling in practical situations, including treatment gap corrections, normal tissue tolerance predictions, optimisation of therapy determined by predictive assays, multi-modality schedule design, the simulation of clinical trials, testing contemporaneous medico-legal problems and teaching general principals of radiotherapy.
DNA Repair and Cancer
DNA repair is a rapidly advancing field in biology and these systems represent a major defense mechanism against environmental and intracellular damaging agents such as sunlight, ionizing radiation, and reactive oxygen species. With contributions from eminent researchers, this book explores the basics and current trends in this critical field. Topics include carcinogenesis as a predictive and/or prognostic biomarker for cancer therapy, nucleotide excision repair, and tumor genetics and personalized medicine. The contributions provide essential information to scientists, pharmaceutical investigators, and clinicians interested in cancer therapy.
Transoral Neck Surgery
This text will serve as a guide for both the head and neck surgeon and the general surgeon in the technical and clinical aspects of transformative transoral neck surgery. It provides the reader with a comprehensive understanding of transoral approaches, including surgical indications, techniques, and outcomes. Such indications include thyroid disease, parathyroid disease, neck dissection, and other head and neck pathology. Instrumentation, setup, and the role of additional technologies such as nerve monitoring and robotics are reviewed in depth, followed by additional chapters on techniques, pearls, pitfalls, controversies, and challenging cases. The volume concludes with the current state of robotics in transoral surgery, and takes a look at future directions. Written and edited by experts in the field, Transoral Neck Surgery will be a valuable guide for the thousands of clinicians implementing this surgery.
Increasing the Therapeutic Ratio of Radiotherapy
Current cancer therapies are focused on three general strategies: modifying intrinsic radiosensitivity via molecular targeting, manipulating microenvironmental factors to enhance tumor susceptibility to radiation, and improving delivery of radiation to critical tumor locations while sparing normal tissues. The goal of this volume is to describe a number of promising approaches corresponding to each strategy. In general, research in radiation oncology tends to be siloed into fundamental biology, physics or treatment delivery. The strategies for improving therapeutic ratio encompassed in this book will involve each of these components of radiation oncology. Thus, they will illustrate the varie...
Robotics in Surgery
Robotics began as a science fiction creation which has become quite real, first in assembly line operations such as automobile manufacturing, airplane construction etc. They have now reached such areas as the ever-multiplying - medical field. Robotic surgery is now becoming highly practised in open heart, lung, and other forms of surgery. This book covers the developing stages of robotic surgery and its expectations in the medical field.
Surgery for Snoring and Obstructive Sleep Apnea Syndrome
Introduction 'Bocca della Verità' or 'Mouth of Truth' is the logo of the Unit for the Study and Therapy of Sleep Respiratory Disorders at the University of Rome 'La Sapienza'. It was chosen because its round shape with surprised expression, small nose and open mouth mirrors the typical face of a patient with OSAS (pre-therapy). The stone (diameter 1.75 m) in fact represents the face of a screaming faun and was originally found in the Mercury Temple area. According to popular legend, anyone putting his hand in the mouth will have it cut off if he has told a lie. When I first became involved in the field of OSAS about ten years ago, I had no idea that this activity would become foremost in bo...
Radiation Injury
This volume explores advances in the clinical management of radiotherapy effects from minor sequelae to major complications. Methods for early diagnosis, correct differential diagnosis and effective intervention and prevention are presented. Contributions to optimal patient care, including new supportive therapies during radiotherapy, and specific indications for drug and surgical interventions after treatment are reviewed. The focus is on defining the critical decision points in management, and the clinical tools most efficient in providing recovery for the patient. A practical and clinically-oriented resource, this volume is especially intended for medical and technical practitioners in oncology: radiation, medical and surgical oncologists and nurses, and radiation physicists, dosimetrists and therapists.
Controversies in Thyroid Surgery
This book encompasses many different diagnoses as well as several specialties of practicing surgeons in the United States. Over the last ten years many advances have been made in preoperative assessment including imaging and diagnostic techniques, operative approaches including “minimally invasive” and robotic surgery, and post operative care. Controversies in Thyroid Surgery explores some of the controversies that arise as the result of these new findings and applications. The book is divided into the two categories of benign diagnosis and cancer topics. Both of these areas lend themselves to separate analysis of specific problems in the areas mentioned above. The text reviews recent da...
