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Comprehensive Structural Integrity
The aim of this major reference work is to provide a first point of entry to the literature for the researchers in any field relating to structural integrity in the form of a definitive research/reference tool which links the various sub-disciplines that comprise the whole of structural integrity. Special emphasis will be given to the interaction between mechanics and materials and structural integrity applications. Because of the interdisciplinary and applied nature of the work, it will be of interest to mechanical engineers and materials scientists from both academic and industrial backgrounds including bioengineering, interface engineering and nanotechnology. The scope of this work encomp...
Limit State of Materials and Structures
To determine the carrying capacity of a structure or a structural element susceptible to operate beyond the elastic limit is an important task in many situations of both mechanical and civil engineering. The so-called “direct methods” play an increasing role due to the fact that they allow rapid access to the request information in mathematically constructive manners. They embrace Limit Analysis, the most developed approach now widely used, and Shakedown Analysis, a powerful extension to the variable repeated loads potentially more economical than step-by-step inelastic analysis. This book is the outcome of a workshop held at the University of Sciences and Technology of Lille. The individual contributions stem from the areas of new numerical developments rendering this methods more attractive for industrial design, extension of the general methodology to new horizons, probabilistic approaches and concrete technological applications.
The History of Theoretical, Material and Computational Mechanics - Mathematics Meets Mechanics and Engineering
This collection of 23 articles is the output of lectures in special sessions on “The History of Theoretical, Material and Computational Mechanics” within the yearly conferences of the GAMM in the years 2010 in Karlsruhe, Germany, 2011 in Graz, Austria, and in 2012 in Darmstadt, Germany; GAMM is the “Association for Applied Mathematics and Mechanics”, founded in 1922 by Ludwig Prandtl and Richard von Mises. The contributions in this volume discuss different aspects of mechanics. They are related to solid and fluid mechanics in general and to specific problems in these areas including the development of numerical solution techniques. In the first part the origins and developments of co...
Direct Methods for Limit State of Materials and Structures
This book provides an overview of direct methods, such as limit and shakedown analysis, which are intended for avoiding cumbersome step-by-step calculations to determine the limit states of mechanical structures under monotone, cyclic or variable actions with unknown loading history. The book comprises several contributions that demonstrate how tremendous advances in numerical methods, especially in optimization, have contributed to the success of direct methods and their applicability to practical engineering problems in structural mechanics and mechanics of materials. The contents reflect the outcomes of the workshop “Direct Methods for Limit State of Materials and Structures,” held in Cosenza, Italy in June 2022.
Allosterism in Drug Discovery
Although the concept of allosterism has been known for over half a century, its application in drug discovery has exploded in recent years. The emergence of novel technologies that enable molecular-level ligand-receptor interactions to be studied in studied in unprecedented detail has driven this trend. This book, written by the leaders in this young research area, describes the latest developments in allosterism for drug discovery. Bringing together research in a diverse range of scientific disciplines, Allosterism in Drug Discovery is a key reference for academics and industrialists interested in understanding allosteric interactions. The book provides an in-depth review of research using small molecules as chemical probes and drug candidates that interact allosterically with proteins of relevance to life sciences and human disease. Knowledge of these interactions can then be applied in the discovery of the novel therapeutics of the future. This book will be useful for people working in all disciplines associated with drug discovery in academia or industry, as well as postgraduate students who may be working in the design of allosteric modulators.
IUTAM Symposium on Theoretical, Computational and Modelling Aspects of Inelastic Media
This work comprises papers based on some of the talks presented at the IUTAM Symposium of the same name, held in Cape Town, January 14-18, 2008. This volume treats cutting-edge issues in modelling, the behaviour of various classes of inelastic media, and associated algorithms for carrying out computational simulations. A key feature of the contributions are works directed at modelling behaviour at the meso and micro-scales, and at bridging the micro-macro scales.
Targets in Gene Therapy
This book aims at providing an up-to-date report to cover key aspects of existing problems in the emerging field of targets in gene therapy. With the contributions in various disciplines of gene therapy, the book brings together major approaches: Target Strategy in Gene Therapy, Gene Therapy of Cancer and Gene Therapy of Other Diseases. This source enables clinicians and researchers to select and effectively utilize new translational approaches in gene therapy and analyze the developments in target strategy in gene therapy.
Advances in Virus Research
Published since 1953, Advances in Virus Research covers a diverse range of in-depth reviews providing a valuable overview of the current field of virology. In 2004, the Institute for Scientific Information released figures showing that the series has an Impact Factor of 2.576, with a half-life of 7.1 years, placing it 11th in the highly competitive category of Virology.
Parvoviruses
This comprehensive reference work brings together for the first time information on every aspect of the parvoviruses in a single volume. It presents the new system of parvovirus classification, as agreed by the International Committee for the Taxonomy of Viruses (ICTV), and includes cutting edge information on the virology, molecular and cellular biology, immunology and clinical manifestations of infection with each known and proposed member of the family Parvoviridae. The book also describes the rapidly expanding basic and clinical science which underpins gene therapy applications using helper-dependent and helper-independent parvoviruses. The respected editorial group has drawn together renowned contributors from around the world to produce what will undoubtedly become the standard reference on the subject. It is essential reading for clinical or research virologists and microbiologists, infectious disease specialists, and public health specialists and laboratories.
