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The renin-angiotensin system (RAS) is a hormonal system that is responsible for regulating plasma sodium ion concentration and arterial blood pressure in the body. The system involves several peptides such as angiotensin I and II as well as angiotensin converting enzyme (ACE) to enable the constriction of arterial blood vessels in the lung. Angiotensin II also stimulates the production of the hormone aldosterone in the kidneys which brings sodium ions into the bloodstream in exchange for potassium ions. Malfunctions of the RAS can lead to hypertension, heart failure, diabetes and renal complications. Thus the biochemical components of this system serve as important targets for therapeutic dr...
Internationally renowned experts have provided data on their own studies, and discuss the relative usefulness of their work in relation to diabetic nephropathy. The first section describes the novel role of intrarenal renin-angiotensin-aldosterone system (RAAS) and oxidative stress in the development of diabetic nephropathy and discusses the current and novel pharmacological interventions in the treatment of diabetic nephropathy. The second section discusses other important contributors outside of the RAAS in the pathogenesis of diabetic nephropathy including AGE/RAGE, epithelial-mesenchymal-transition (EMT) and immune cytokines. Features: Provides novel information on various pathophysiological determinants in the development of diabetic nephropathy Provides novel information on various pharmacological interventions of diabetic nephropathy
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The novel discipline of proteomics has experienced a rapid growth in the recent past and has a great potential for the future. Involving several fields, it offers various advantages: The study of proteins on a genomic scale allows to examine a large number of them simultaneously. Moreover, proteomic analysis provides information about post-translational modifications and functions of gene products or proteins that cannot be obtained by genomic analysis. The knowledge thus gained is also important for a better understanding of renal physiology and pathophysiology, to identify disease biomarkers, and to develop new target therapies.This book is the first one that applies the science of proteom...
Current interactional linguistic research appears to be crystallizing around systematic themes, which are all represented in this collection of papers. In the first section, where the relation between language and interaction is viewed from the perspective of language structure, several articles deal with the potential of a single structure for both turn and sequence construction, revealing a play-off between planned and occasioned syntax with potentially far-reaching consequences for language development. Other articles deal with lexical expressions as resources for the conduct of interaction, showing how they are heavily dependent on turn position and sequential context for their meaning p...
"Reviewing recent findings on linguistic practices used in turn construction and turn taking, repair, action formation and ascription, sequence and topic organization, the book examines the way linguistic units of varying size - sentences, clauses, phrases, clause combinations, particles - are mobilized for the implementation of specific actions in talk-in-interaction. A final chapter discusses the implications of an interactional perspective for our understanding of language as well as its variation, diversity, and universality. Supplementary online chapters explore additional topics such as the linguistic organization of preference, stance, footing, and storytelling, as well as the use of prosody and phonetics, and further practices with language"--
* A TIMES BEST SCIENCE BOOK OF THE YEAR * From the prize-winning author of Adventures in the Anthropocene, the astonishing story of how culture enabled us to become the most successful species on Earth 'A wondrous, visionary work' Tim Flannery, author of The Weather Makers Humans are a planet-altering force. Gaia Vince argues that our unique ability - compared with other species - to determine the course of our own destiny rests on a special relationship between our genes, environment and culture going back into deep time. It is our collective culture, rather than our individual intelligence, that makes humans unique. Vince shows how four evolutionary drivers - Fire, Language, Beauty and Tim...
In the last decade, the relationship between settler Canadians and Indigenous Peoples has been highlighted by the Truth and Reconciliation Commission, the National Inquiry into Missing and Murdered Indigenous Women and Girls, the Idle No More movement, the Wet’suwet’en struggle against pipeline development and other Indigenous-led struggles for Indigenous sovereignty and decolonization. Increasing numbers of Canadians are beginning to recognize how settler colonialism continues to shape relationships on these lands. With this recognition comes the question many settler Canadians are now asking, what can I do? Living in Indigenous Sovereignty lifts up the wisdom of Indigenous scholars, ac...
This book reflects the current status of theoretical and experimental research of graphene based nanostructures, in particular quantum dots, at a level accessible to young researchers, graduate students, experimentalists and theorists. It presents the current state of research of graphene quantum dots, a single or few monolayer thick islands of graphene. It introduces the reader to the electronic and optical properties of graphite, intercalated graphite and graphene, including Dirac fermions, Berry's phase associated with sublattices and valley degeneracy, covers single particle properties of graphene quantum dots, electron-electron interaction, magnetic properties and optical properties of ...