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The Victims at the Berlin Wall, 1961-1989
Although many deaths at the Berlin Wall have been publicized over the years in the media, the number, identity and fate of the victims still remain largely unknown. This handbook changes this by answering the following questions: How many people actually died at the Berlin Wall between 1961 and 1989? Who were these people? How did they die? How were their relatives and their friends treated after their deaths? What public and political reactions were triggered in the East and the West by these fatalities? What were the consequences for the border guards who pulled the trigger and the military and political leaders who gave them their orders after the East German border regime collapsed and the Wall fell? How have the victims been commemorated since their deaths? By documenting the lives and circumstances under which these men and women died at the Wall, these deaths are placed in a contemporary historical context. The authors, in addition to systematically researching the relevant archives and examining all the legal proceedings and Stasi documents, also conducted interviews with family members and contemporary witnesses.
Immunology of Infection
Immunology of Infection, 3e, edited by two leading experts in the field, presents the most appropriate up-to-date experimental approaches in the detail required for modern microbiological research. Focusing on the methods most useful for the microbiologist interested in analyzing host-pathogen relationships, this volume will be essential reading for all researchers working in microbiology, immunology, virology, mycology and parasitology. This new edition of Immunology of Infection provides ready-to-use "recipes" and the latest emerging techniques as well as novel approaches to the tried and tested, established methods included in the successful first edition. Methods in Microbiology is the most prestigious series devoted to techniques and methodology in the field. Established for over 30 years, Methods in Microbiology will continue to provide you with tried and tested, cutting-edge protocols to directly benefit your research.
New insights into innate immune cell-based immunotherapies in cancer
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Treatment of Autoimmune Disorders
Progress in basic and clinical immunology within the last two decades has provided profound insight into the immune system and its role in preventing endogenous and exogenous damage. In contrast, disbalances within this system can result in autoimmune disorders which may affect diverse organs and result in distinct clinical pictures. In many of these, however, the individual etiopathogenetic mechanisms are poorly understood and even more their clinical symptoms are hard to treat. The book offers insight into basic mechanisms of autoimmune disorders. It includes neurological, gastrointestinal, ophthalmological and skin diseases as well as current and future therapeutic options including immunomodulatory drugs and different vaccination strategies. By addressing diverse organ systems, both singular and shared features are elaborated. Thus an exchange of ideas is intended across research on single organ systems within a truly interdisciplinary setting.
Tumor Immunology and Immunotherapy - Cellular Methods Part A
Tumor Immunology and Immunotherapy - Cellular Methods Part A, Volume 631, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. New chapters include Detection of intracellular cytokine production by T cells with flow cytometry, High-throughput identification of human antigen-specific CD8+ and CD4+ T cells using soluble pMHC multimers, In vitro assays for effector T cell functions and activity of immunostimulatory antibodies, Ex vivo energetic profiling of tumor cells and T cells from mouse models and human samples, A cytofluorimetric assay to evaluate T cell polyfunctionality, and much more.
Emerging Concepts on the NKG2D Receptor- NKG2D Ligand Axis in Health and Diseases
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Band T Cell Tumors
B and T Cell Tumors documents the proceedings of the 1982 International Conference on ""B and T Cell Tumors: Biological and Clinical Aspects"" held in Squaw Valley, California. The meeting was one of the conferences of the 1982 UCLA Symposia on Molecular and Cellular Biology series. This book is organized into six parts encompassing 79 chapters. Considerable chapters tackle the origin and classification of tumors; normal clones of T and B cells; differentiation of T and B cell tumors; regulation of tumor growth and tumor therapy. Each topic is discussed based on the results obtained in human and animal models in the laboratory. Other chapters explore lymphoid neoplasms and the enormous progr...
T-Cell Subsets and Cytokines Interplay in Infectious Diseases
Presenting a wealth of new data on the interaction among T-cell subsets and cytokines, this book offers a fresh perspective on infectious diseases. It provides useful insights into the nature and treatment of helminthic and mycobacterial infections, with special emphasis on leprosy, leishmaniasis, malaria and trypanosomiasis. The outcome of the host response to infectious agent is seen as depending upon the T-cell subsets activated and the cytokines produced by them and other cells, such as macrophages, B cells and basophils. Experts contributions shed new light on how TH0 cells are preferentially activated and differentiated into TH1 or TH2 subsets; TH1 and TH2 cells and their cytokines induce both protective immune responses and adverse immune reactions to infectious agents; cytokines modulate the response of infectious diseases to chemotherapy; and cytokines, their receptors and antagonist, and anti-cytokine antibodies can be used in therapy. Those working in the fields of immunology, parasitology, microbiology and vaccine development particularly if they are interested in tropical diseases, will find the volume an invaluable source of information.
The Present and Future of Immunology Education
The explosion of basic and applied immunology in the first decades of the 21st century has brought forth new opportunities and challenges for immunology education at all academic levels, from professional to undergraduate, medical, graduate and post-graduate instruction. Moreover, developing methods and techniques for educating general audiences on the importance and benefits of immunology will be critical for increasing public awareness and support. One major immediate challenge consists in accommodating, within the confines of traditional immunology curricula, a body of knowledge that continues to grow exponentially in both size and complexity. Furthermore, the practical toolbox of immunol...
Cellular Diagnostics
This book is the updated English version of the 2006 German bestseller Zellulare Diagnostik, a comprehensive presentation of flow cytometry and its applications. While some techniques of immunophenotyping by flow cytometry already are routine procedures in the laboratory, new methods for the functional characterization of cells, the analysis of rare cells, and the diagnosis of complex materials have only begun to win wide recognition. New approaches such as slide-based cytometry will lead to an increase in the use of cytometric techniques. Multiparameter approaches will further improve analysis. The book provides a comprehensive and detailed compilation of all aspects of flow cytometry in research and the clinic. For newcomers it offers a thorough introduction, for advanced users, specific protocols and interpretation assistance.
