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Toll-like Receptors in Inflammation
A repertoire of 10 TLRs mediate the first response to all microbes that infect mammals. They are the long sought receptors for a wide range of microbial products. Notable examples include TLR4 which recognizes LPS from gram negative bacteria, TLR3 which recognizes viral double-stranded RNA and TLR9 which recognizes CpG DNA motifs, found commonly in both viruses and bacteria. TLRs are increasingly being implicated in both infectious and inflammatory diseases, notable examples being sepsis, inflammatory bowel disease, atherosclerosis and asthma. There is therefore great interest in targeting TLRs therapeutically since blocking TLRs will result in a decrease in the production of inflammatory mediators such as TNF. This volume covers our current understanding of TLRs, and their role in inflammation. Given the primacy of TLRs in the inflammatory process and their emerging role in inflammatory diseases the book is of great interest to researchers working in inflammation and immunology.
A true register of all the christenings, mariages, and burialles in the parishe of st.James, Clarkenwell, from ... 1551 (to 1754), ed. by R.Hovenden
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AACR 2022 Proceedings: Part B April 11-13
The AACR Annual Meeting is the focal point of the cancer research community, where scientists, clinicians, other health care professionals, survivors, patients, and advocates gather to share the latest advances in cancer science and medicine. From population science and prevention; to cancer biology, translational, and clinical studies; to survivorship and advocacy; the AACR Annual Meeting highlights the work of the best minds in cancer research from institutions all over the world.
A True Register of All Christeninges, Mariages, and Burialles in the Parishe of St. James, Clarkenwell
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Valentine Peers
Biography and family history of Valentine Peers (1756-1830), of Scottish lineage, who immigrated from Ireland to Alexandria, Virginia during or before 1774, served in the Revolutionary War, moved to Prince William County, Virginia, married twice, and moved to Maysville, Kentucky. Descendants lived in Virginia, Kentucky, Ohio, Missouri, Illinois, Mississippi, Arkansas, Texas and elsewhere.
Charlton Kings Parish Registers: Baptisms & burials 1760-1812 ; marriages 1754-1812
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