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Innovations for Next-Generation Antibody-Drug Conjugates
Antibody-drug conjugates (ADCs) stand at the verge of a transformation. Scores of clinical programs have yielded only a few regulatory approvals, but a wave of technological innovation now empowers us to overcome past technical challenges. This volume focuses on the next generation of ADCs and the innovations that will enable them. The book inspires the future by integrating the field’s history with novel strategies and cutting-edge technologies. While the book primarily addresses ADCs for solid tumors, the last chapter explores the emerging interest in using ADCs to treat other diseases. The therapeutic rationale of ADCs is strong: to direct small molecules to the desired site of action (...
The Danubian Lands between the Black, Aegean and Adriatic Seas
Proceedings of the Fifth International Congress on Black Sea Antiquities (Belgrade - 17-21 September 2013). The theme of the congress included archaeological, historical, linguistic, anthropological, geographical and other investigations across the huge area through which the Argonauts passed in seeking to return from Colchis.
Rei Cretariae Romanae Fautorum: Acta 46
Acta 46 comprises 64 articles. Out of the 120 scheduled lectures and posters presented at the 31st Congress of the Rei Cretariæ Romanæ Favtores, 61 are included in the present volume, to which three further were added. Given the location of the conference in Romania it seems natural that there is a particular focus on the Balkans and Danube.
Freedoms Delayed
According to diverse indices of political performance, the Middle East is the world's least free region. Some believe that it is Islam that hinders liberalization. Others retort that Islam cannot be a factor because the region is no longer governed under Islamic law. This book by Timur Kuran, author of the influential Long Divergence, explores the lasting political effects of the Middle East's lengthy exposure to Islamic law. It identifies several channels through which Islamic institutions, both defunct and still active, have limited the expansion of basic freedoms under political regimes of all stripes: secular dictatorships, electoral democracies, monarchies legitimated through Islam, and theocracies. Kuran suggests that Islam's rich history carries within it the seeds of liberalization on many fronts; and that the Middle East has already established certain prerequisites for a liberal order. But there is no quick fix for the region's prevailing record of human freedoms.
The Ottoman Press (1908-1923)
The Ottoman Press (1908-1923) looks at Ottoman periodicals in the period after the Second Constitutional Revolution (1908) and the formation of the Turkish Republic (1923). It analyses the increased activity in the press following the revolution, legislation that was put in place to control the press, the financial aspects of running a publication, preventive censorship and the impact that the press could have on readers. There is also a chapter on the emergence and growth of the Ottoman press from 1831 until 1908, which helps readers to contextualize the post-revolution press.
The Last Days of the Ottoman Empire
'A tour de force of accessible scholarship' The Guardian 'Impressive ... It is a complicated story that still reverberates, and Gingeras narrates it with lucid authority' New Statesman The Ottoman Empire had been one of the major facts in European history since the Middle Ages. Stretching from the Adriatic to the Indian Ocean, the Empire was both a great political entity and a religious one, with the Sultan ruling over the Holy Sites and, as Caliph, the successor to Mohammed. Yet the Empire's fateful decision to support Germany and Austria-Hungary in 1914 doomed it to disaster, breaking it up into a series of European colonies and what emerged as an independent Saudi Arabia. Ryan Gingeras's superb new book explains how these epochal events came about and shows how much we still live in the shadow of decisions taken so long ago. Would all of the Empire fall to marauding Allied armies, or could something be saved? In such an ethnically and religiously entangled region, what would be the price paid to create a cohesive and independent new state? The story of the creation of modern Turkey is an extraordinary, bitter epic, brilliantly told here.
Mouldmade Bowls of the Black Sea Region and Beyond
This book opens up a new window into the Hellenistic world through a close study of mouldmade bowls, their places of production (both in the Black Sea and the Mediterranean), iconographies and distribution. The author’s unique access to material in the Black Sea Region provides the backbone to a rare comparative approach to an important type of vessel that traditionally has been studied in local isolation.
Artificial Intelligence in Healthcare
This book presents state-of-the-art research works for a better understanding of the advantages and limitations of AI techniques in the field of healthcare. It will further discuss artificial intelligence applications in depression, hypertension and diabetes management. The text also presents an artificial intelligence chatbot for depression, diabetes, and hypertension self-help. This book: Provides a structured overview of recent developments of artificial intelligence applications in the healthcare sector. Presents an in-depth understanding of how artificial intelligence techniques can be applied to diabetes management. Showcases supervised learning techniques based on datasets for depression management. Discusses artificial intelligence chatbot for diabetes, depression, and hypertension self-care. Highlights the importance of artificial intelligence in managing and predicting diabetes, hypertension, and depression. The text is primarily written for senior undergraduate, graduate students, and academic researchers in diverse fields including electrical engineering, electronics and communications engineering, computer science and engineering, and biomedical engineering.
Women in the Ottoman Empire
It is an often ignored but fundamental fact that in the Ottoman world, as in most empires, there were 'first-class' and 'second class' subjects. Among the townspeople, peasants and nomads subject to the sultans, who might be Muslims or non-Muslims, adult Muslim males were first-class subjects and all others, including Muslim boys and women, were of the second class. As for the female members of the elite, while less privileged than the males, in some respects their life chances might be better than those of ordinary women. Even so, they shared the risks of pregnancy, childbirth and epidemic diseases with townswomen of the subject class and to a certain extent, with village women as well. Thu...
New Directions and Paradigms for the Study of Greek Architecture
New Directions and Paradigms for the Study of Greek Architecture comprises 20 chapters by nearly three dozen scholars who describe recent discoveries, new theoretical frameworks, and applications of cutting-edge techniques in their architectural research. The contributions are united by several broad themes that represent the current directions of study in the field, i.e.: the organization and techniques used by ancient Greek builders and designers; the use and life history of Greek monuments over time; the communication of ancient monuments with their intended audiences together with their reception by later viewers; the mining of large sets of architectural data for socio-economic inference; and the recreation and simulation of audio-visual experiences of ancient monuments and sites by means of digital technologies.
