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DNA Replication, Recombination, and Repair
This book is a comprehensive review of the detailed molecular mechanisms of and functional crosstalk among the replication, recombination, and repair of DNA (collectively called the "3Rs") and the related processes, with special consciousness of their biological and clinical consequences. The 3Rs are fundamental molecular mechanisms for organisms to maintain and sometimes intentionally alter genetic information. DNA replication, recombination, and repair, individually, have been important subjects of molecular biology since its emergence, but we have recently become aware that the 3Rs are actually much more intimately related to one another than we used to realize. Furthermore, the 3R resear...
DNA Replication and Human Disease
At least 5 trillion cell divisions are required for a fertilized egg to develop into an adult human, resulting in the production of more than 20 trillion meters of DNA! And yet, with only two exceptions, the genome is replicated once and only once each time a cell divides. How is this feat accomplished? What happens when errors occur? This book addresses these questions by presenting a thorough analysis of the molecular events that govern DNA replication in eukaryotic cells. The association between genome replication and cell proliferation, disease pathogenesis, and the development of targeted therapeutics is also addressed. At least 160 proteins are involved in replicating the human genome,...
Pisidian Antioch
The city of Pisidian Antioch was founded in the hellenistic period by the Seleucids, in what is now south-west Turkey. Under the emperor Augustus it became the most important Roman colony of the eastern empire. The city flourished until the sixth century AD. It has left dramatic and extensive ruins. This comprehensive and fully-illustrated study, a sequel to Mitchell's Cremna in Pisidia, is based on a new survey of the site. It also includes the results of the most recent Turkish field work as well as detailed information from the important but unpublished 1924 excavation by the University of Michigan.
Aivazovsky
The seascapes of Ivan Aivazovsky (1817-1900) made his name in Russia, his native country where he was a painter of the court of Nicholas I, yet his fame barely extended beyond these borders. Master of the Sublime, he made the ocean the principal subject of his work. Sometimes wild and raging, sometimes calm and peaceful, the life of the ocean is composed of as many allegories as the human condition. Like Turner, whom he knew and whose art he admired, he never painted outside in nature, nor did he make preliminary sketches; his paintings were the fruit of his exceptional memory. With more than 6,000 canvasses, Aivazovsky was one of the most prolific painters of his time.
Rome, the Greek World, and the East
Fergus Millar is one of the most influential contemporary historians of the ancient world. His essays and books, including The Emperor in the Roman World and The Roman Near East, have enriched our understanding of the Greco-Roman world in fundamental ways. In his writings Millar has made the inhabitants of the Roman Empire central to our conception of how the empire functioned. He also has shown how and why Rabbinic Judaism, Christianity, and Islam evolved from within the wider cultural context of the Greco-Roman world. Opening this collection of sixteen essays is a new contribution by Millar in which he defends the continuing significance of the study of Classics and argues for expanding the definition of what constitutes that field. In this volume he also questions the dominant scholarly interpretation of politics in the Roman Republic, arguing that the Roman people, not the Senate, were the sovereign power in Republican Rome. In so doing he sheds new light on the establishment of a new regime by the first Roman emperor, Caesar Augustus.
Gregory of Nazianzus
Gregory of Nazianzus (ca. 330-390) is one of the three Greek church fathers from Cappadocia. This book explores both his theology and his general importance as an independent thinker, profile writer, orator, and poet. Gregory has often been in the shadow of the other Cappadocians - Basil of Ceasarea and Gregory of Nyssa.
Holiness and Masculinity in the Middle Ages
Studies in gender in medieval culture have tended to focus on femininity, however the study of medieval masculinities has developed greatly over the last few years. Holiness and Masculinity in the Middle Ages is the first volume to concentrate on this specific aspect of medieval gender studies, and looks at the ways in which varieties of medieval masculinity intersected with concepts of holiness. Patricia Cullum and Katherine J. Lewis have collected an exceptional group of essays that explore differing notions of medieval holiness, understood variously as religious, saintly, sacred, pure, morally perfect, and consider topics such as significance of the tonsure, sanctity and martyrdom, eunuch saints, and the writings of Henry Suso. Holiness and Masculinity in the Middle Ages deals with a wide variety of texts and historical contexts, from Byzantium to Anglo-Saxon and late-medieval England.
Vandals, Romans and Berbers
The birth, growth and decline of the Vandal and Berber Kingdoms in North Africa have often been forgotten in studies of the late Roman and post-Roman West. Although recent archaeological activity has alleviated this situation, the vast and disparate body of written evidence from the region remains comparatively neglected. The present volume attempts to redress this imbalance through an examination of the changing cultural landscape of 5th- and 6th-century North Africa. Many questions that have been central within other areas of Late Antique studies are here asked of the North African evidence for the first time. Vandals, Romans and Berbers considers issues of ethnicity, identity and state fo...
