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Meselson, Stahl, and the Replication of DNA
In 1957 two young scientists, Matthew Meselson and Frank Stahl, produced a landmark experiment confirming that DNA replicates as predicted by the double helix structure Watson and Crick had recently proposed. It also gained immediate renown as a “most beautiful” experiment whose beauty was tied to its simplicity. Yet the investigative path that led to the experiment was anything but simple, Frederic L. Holmes shows in this masterful account of Meselson and Stahl’s quest. This book vividly reconstructs the complex route that led to the Meselson-Stahl experiment and provides an inside view of day-to-day scientific research--its unpredictability, excitement, intellectual challenge, and se...
Instruments and Experimentation in the History of Chemistry
This volume moves chemical instruments and experiments into the foreground of historical concern, in line with the emphasis on practice that characterizes current work on other fields of science and engineering.
Lavoisier and the Chemistry of Life
Drawing on Lavoisier's daily laboratory records, unpublished notes, and successive drafts of articles, Holmes explores the interaction between this creative scientist's theories and practice, the experimental problems he encountered and his response to them, the apparently intuitive understanding that guided his choice of experiments, and the gradual refinement of his hypotheses. This thorough and comprehensive exposition of Lavoisier's scientific style forms the basis for general reflections on the nature of creative scientific imagination that will interest historians of science and biology, philosophers of science, cognitive psychologists, and all who are intrigued by the drama of pioneering scientific discovery.
Reconceiving the Gene
This book relates how, between 1954 and 1961, the biologist Seymour Benzer mapped the fine structure of the rII region of the genome of the bacterial virus known as phage T4. Benzer’s accomplishments are widely recognized as a tipping point in mid-twentieth-century molecular biology when the nature of the gene was recast in molecular terms. More often than any other individual, he is considered to have led geneticists from the classical gene into the molecular age. Drawing on Benzer’s remarkably complete record of his experiments, his correspondence, and published sources, this book reconstructs how the former physicist initiated his work in phage biology and achieved his landmark investigation. The account of Benzer’s creativity as a researcher is a fascinating story that also reveals intriguing aspects common to the scientific enterprise.
Reworking the Bench
This is the first book that addresses the issue of research notes for writing history of science in a comprehensive manner. Its case studies range from the early modern period to present and cover a broad range of different disciplines. The contributions are based on papers presented at the workshop entitled "Reworking the Bench: Laboratory Notebooks in the History of Science", held at the Max Planck Institute for the History of Science in Berlin or written after the workshop.
History of Analytical Chemistry
History of Analytical Chemistry is a systematic account of the historical development of analytical chemistry spanning about 4,000 years. Many scientists who have helped to develop the methods of analytical chemistry are mentioned. Various methods of analysis are discussed, including electrogravimetry, optical methods, electrometric analysis, radiochemical analysis, and chromatography. This volume is comprised of 14 chapters and begins with an overview of analytical chemistry in ancient Greece, the origin of chemistry, and the earliest knowledge of analysis. The next chapter focuses on analytical chemistry during the Middle Ages, with emphasis on alchemy. Analytical knowledge during the peri...
The Adventure of the Dancing Men and Other Sherlock Holmes Stories
Title story plus three others featuring the peerless sleuth and his faithful sidekick: "The Adventure of the Dying Detective," "The Musgrave Ritual" and "The Adventure of the Bruce-Partington Plans."
New Dictionary of Scientific Biography
Also available online as part of the Gale Virtual Reference Library under the title Complete dictionary of scientific biography.
Lithic Technological Organization and Paleoenvironmental Change
The objective of this edited volume is to bring together a diverse set of analyses to document how small-scale societies responded to paleoenvironmental change based on the evidence of their lithic technologies. The contributions bring together an international forum for interpreting changes in technological organization - embracing a wide range of time periods, geographic regions and methodological approaches. As technology brings more refined information on ancient climates, the research on spatial and temporal variability of paleoenvironmental changes. In turn, this has also broadened considerations of the many ways that prehistoric hunter-gatherers may have responded to fluctuations in resource bases. From an archaeological perspective, stone tools and their associated debitage provide clues to understanding these past choices and decisions, and help to further the investigation into how variable human responses may have been. Despite significant advances in the theory and methodology of lithic technological analysis, there have been few attempts to link these developments to paleoenvironmental research on a global scale.
