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A volume on the biliary system appeared in 1965, based on a symposium of the NATO Advanced Institute held in September, 1963, in Newcastle upon Tyne in England. It soon became an authorita tive text on the problems of the biliary tract and, for instance, the discussion on the biliary secretion of organic anions, organic cations and inorganic ions were classic references. The worn pages of the volume in many libraries, including my own, bespeak its usefulness over ten long years. The initiative and energy of the Director of the first Institute have to be admired, even more so since he was able to assemble a Second Institute in Aalborg, Denmark, in 1975. His wisdom is reflected in the selectio...
Over a decade has elapsed since the last volume in this series was published. At that time we considered that we had comprehensively covered all aspects relating to bile acid chemistry and physiology. However, major strides have been made in our understanding of the physiology and pathophysiology of bile acids, due largely to the great advances which have taken place in analytical technology. As a result, the need to document these advances was felt acutely, and therefore this volume is devoted to methodologies in bile acid analysis and their applications. This volume includes twelve chapters written by prominent scientists in the field of bile acid research. The initial chapter discusses te...
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This was an important Symposium in a rapidly developing field of interest. It was designed to draw attention to areas which have been neglected in standard hepatology textbooks and to review areas of controversy. It was also meant to help bridge the communication gap between hepatologists'caring for children and adults as well as between some areas of clinical and basic research. The Symposium was a substantial success. Unfortunately two of the twenty participants did not deliver a manuscript. The result is a publication which is late and which is not as complete as it should be. For this lateness and incompleteness the editors apolo gize most sincerely--especially to those participants who ...
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This book, the proceedings of the Falk Syposium No. 139 on "Gallstones: Pathogenesis and Treatment", held in Freiburg, Germany, on January 15-16, 2004, reflects the tremendous advances in the field of biliary diseases both at the genetic and cellular as well as the clinical levels. In industrialized countries, gallstones are a frequent clinical entity with a prevalence of 10-15%. In clinical practice one can differentiate between cholesterol stones, black pigment stones and brown pigment stones. 80-90% of gallbladder stones are cholesterol stones, 10--20% are black pigment stones. The prevalence of cholesterol stones increases with age and in Europe in the 70+ age group reaches about 20% in ...