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Plasma Lipids
Plasma Lipids: Optimal Levels for Health compiles reports on optimal blood lipid levels. This book discusses the optimal levels of blood lipids that suffice for optimal physical and mental development of man while at the same time does not detrimentally affect human health. Clinical, epidemiological, and experimental evidence agrees that the ideal (optimal) serum cholesterol level for children aged 10-14 should be 120 mg% and that the ideal (optimal) cholesterol level for adults should be 160 mg%. This text stresses that if these are indeed the optimal levels, and so many people have levels far above these values, then it is evident why a large proportion of the population succumbs to cardiovascular disease. This publication is intended for physicians and scientists concerned with the optimal values of health.
Low Density Lipoproteins
Low density lipoproteins (LDL) are pathophysiologically important be cause of their central role in the disease atherosclerosis and because atherosclerosis is the leading cause of death in developed countries. Many researchers believe that a more detailed knowledge of the struc ture, function, and metabolism of LDL may eventually lead to a means to control atherosclerosis. For this reason a fairly large research effort has gone into the investigation of LDL over the past few years. The purpose of this book is to collect and summarize in one place most of the pub lished information on LDL through 1975. To this end more than 1500 references are cited in the papers that make up this volume. The A, B, C apolipoprotein classification system was adopted for use throughout this work. In addition to the A, B, C, and "D" families of apolipoproteins, apoE is used to designate the "arginine-rich" apolipo protein. This classification system is used because it is far less cumber some than other proposed classification schemes for apolipoproteins.
The Gangliosidoses
The history of so-called storage diseases goes back to the end of the 19th and to the beginning of the 20th century when Fabry, Tay, Sachs, Gaucher, Niemann, Hunter, and Hurler first described the disorders which up to now are called by their eponym. The clinical descriptions soon were followed by pathologic studies, and within a short time ,the hereditary characters of these rare afflictions came to be recognized. Although sporadic reports during the early part of this century dealt with biochemical analysis of the "stored" materials in these disorders, it was actually in the late 1930s that the abnormal deposits started to attract the increasing attention of chemists. S. H. Thannhauser bro...
Regression of Atherosclerotic Lesions
The Advanced Study Institute on Regression of Atherosclerotic Lesions, sponsored by the North Atlantic Treaty Organization, was held in Maratea, Italy, September 11-13, 1983. The institute was designed to foster discussion of experimental data on the regression of atherosclerosis in animals and evidence of a similar phenomenon in humans. The participating scientists showed with anatomical and biochemical data, that atherosclerosis regresses in cholesterol fed animals after withdrawal of atherogenic stimuli. The existence of regression in humans was inferred from sequential angiographic visualization of arteries, but anatomical and biochemical characteristics of the process have not been defi...
Towards A Nuclear-weapon-free World - Proceedings Of The Forty-fifth Pugwash Conference On Science And World Affairs
In this volume, scientists write on the desirability and feasibility of eliminating nuclear weapons, including reflections 50 years after the destruction of Hiroshima and Nagasaki by atomic bombs. The following topics are discussed: strategies for preventing the proliferation of weapons of mass destruction; ways and means to monitor and control the arms trade; the need for global governance; specific aspects of security in the Asia-Pacific region; and interactions between the problems of meeting the world's energy demand, reducing environmental pollution, and promoting sustainable development.
The Biology of Cholesterol and Related Steroids
The Biology of Cholesterol and Related Steroids focuses on the study of sterols in relation to living organisms. The publication first takes a look at the analysis of sterols and related steroids and the distribution of sterols and related steroids in nature, as well as the processes of extraction and separation and presence of sterols in plants, fungi, vertebrates, and invertebrates. The text then ponders on biosynthesis of sterols and metabolism of cholesterol. Topics include formation of fatty acid esters of cholesterol, steroid hormones, biosynthetic pathway to sterols, reaction mechanisms, and comparative aspects of sterol synthesis. The manuscript examines the developmental aspects of ...
The Healing and Scarring of Atheroma
The study of atherosclerosis centered since the first decade of the present century on etiology and pathogenesis. In fact, the studies of the military academy of medicine in St. Petersburg have opened the way of inducing atherosclerosis in animals. Pathogenesis of atheroma has been studied since then in humans and animals naturally prone to the development of the disease and by a variety of dietary and other procedures. The various experimental studies allowed science to evaluate the relative importance of different factors (genetic, dietary, hormonal, pharmacological. mechanical, circulatory, etc.) in atherogenesis. Epidemiological studies as well as biochemical plasma lipid and lipoprotein estimations coupled with light microscopic, histo chemical and electron microscopic investigations decreased the gap between observations on the human and experimental animal research. The enormous literature covering this field allows the intelligent reader to formulate a comprehensive concept regarding etiological factors and pathogenesis of atherosclerosis. Its impact on pre ventive and curative medicine was however limited in scope.
