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Biological and Clinical Landscape of Meningiomas
"Meningiomas are tumors that originate from the arachnoidal cap cells of the leptomeninges. With an incidence rate of 8.36 per 100, 000 population, they are the most common primary central nervous system (CNS) tumors, accounting for a third of all cases. The World Health Organization (WHO) classification has traditionally categorized meningiomas into 15 different histopathological subtypes and three clinical grades. Tumors are classified as WHO grades 1, 2 or 3 based largely on histopathological features such as mitotic activity, presence of brain invasion, and other atypical features. However, there is increasing recognition of the limitations of histopathology including but not limited to:...
Tumor Angiogenesis
Tumor angiogenesis is the main process responsible for the formation of new blood vessels that promote tumor growth and metastasis. This process is driven by potent pro-angiogenic factors that are predominant in the tumor environment and are produced by both malignant cells and the host cells recruited to the tumor site. Tumor environment is characterized by the imbalance between pro-angiogenic and anti-angiogenic factors, which drives the construction of numerous but structurally defective vessels. These poorly perfused and abnormal vessels significantly contribute to the tumor pathology not only by supporting the expansion of the tumor mass but also by promoting chronic inflammation, enhan...
Neurology
Neurology: A Queen Square Textbook, second edition, is a fully revised and updated companion that demonstrates the rapid pace of advancement within clinical neurology and applied neurosciences A comprehensive and practical overview of current developments within clinical neurology, synthesising clinical neurology with translational research Expertly edited and written by neurologists, neuroscientists and neurosurgeons working at Queen Square, advised by an distinguished International Editor team to present a global perspective Introductory chapters summarise the basic sciences underpinning the practice of clinical neurology, including genetics, channelopathies, immunology, neurophysiology an...
Oncology of CNS Tumors
This book is an easy-to-use reference that provides ready guidance on the diagnosis and treatment of the full range of tumors of the central nervous system in adults and children. The new edition has been completely revised to reflect the continually evolving landscape of neuro-oncology and provide readers with a thorough update that will inform their clinical practice. Since the previous edition, molecular neuropathology has progressed considerably, leading to a new understanding of specific clinical entities with corresponding changes in treatment concepts. Moreover, tumor biology has become better integrated with clinical neuro-oncology in truly translational efforts. These advances receive detailed attention. In addition, the structure of the book has been adapted to align with the revised 2016 version of the WHO Brain Tumor Classification. Once again, the contributors have been carefully selected as leading experts in the field. Oncology of CNS Tumors is already established as a widely used reference, and this new edition will provide optimal value for highly specialized comprehensive neuro-oncology centers as well as practicing clinicians and researchers.
The Canada Gairdner Awards Collection: Celebrating Outstanding Health Researchers
Many great scientists are driven by the desire to understand and improve human health. This is a common desire—we all wish to experience good health throughout our lives, and to receive effective medical treatment if we get injured or sick. Scientists that study health-related questions are leading this journey towards improved human wellbeing. Their jobs are incredibly challenging, because the human body is extremely complex. Countless bodily processes are constantly occurring, all at the same time. Understanding even one process takes great effort, but it is an even bigger challenge to understand the relationships between processes and how these interrelated processes affect human health...
New Approaches to the Management of Primary and Secondary CNS Tumors
Several new concepts are reviewed and discussed in this book and allude to the transport of drugs bound to red blood cells into the vascular blood-brain barrier and into cancer cells. Such a transport system is novel and of potential therapeutic potential. It is the goal of this book to provide information and data that will be useful for others to develop new approaches for the management of CNS malignancies.
Intrinsic and Skull Base Tumors - E-Book
Unique in the field, Intrinsic and Skull Base Tumors presents commonly encountered skull base and intrinsic neoplasm cases with side-by-side, case-by-case comparisons that clearly show how various experts would handle the same case. This inaugural volume in the Neurosurgery: Case Comparison Series offers multiple opinions from international experts in neurosurgery who provide various approaches and management styles for the same case. This format allows for quick and helpful comparisons of different ways to approach a lesion, advantages and disadvantages of each approach, and what each expert is looking for in how they would manage a particular case. - Offers 3 to 4 expert opinions on each c...
It Takes a Village: The Expanding Multi-Disciplinary Approach to Brain Metastasis
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The Circus Train
International Bestseller and #1 LibraryReads Pick Water for Elephants meets The Night Circus in this World War II debut about a magnificent travelling circus, a star-crossed romance, and one girl’s coming-of-age during the darkest of times. “A powerful reminder that to live is not just to survive, but to be seen and known for ourselves.” —Pam Jenoff, author of The Orphan’s Tale When all is lost, how do you find the courage to keep moving forward? 1938. Lena Papadopoulos has never quite found her place within the circus, even as the daughter of the extraordinary headlining illusionist, Theo. Brilliant and curious, Lena—who uses a wheelchair after a childhood bout with polio—year...
Metabolic Structure and Regulation
There is a renewed interest in the fundamentals of energy metabolism, yet most people base their understanding on the views of generalists expressed in elementary textbooks. New techniques that enable analysis of thousands of metabolites provide useful data, but do not themselves substitute for an understanding of the fundamentals of metabolism. While classical ideas of metabolism are also valuable, some earlier ideas have not withstood further investigation. This book presents a personal philosophy but rests on what is broadly accepted by metabolic biochemists over the past few decades.
