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70 Years of Levothyroxine
This open access book presents the history, pharmacokinetics and pharmacodynamics of levothyroxine, discussing its role in the thyroid pathophysiology of patients of various ages and during pregnancy. It also describes the influence of levothyroxine on heart, bone and in cancer. When it was first synthesized in 1949, levothyroxine represented a significant advance in the treatment of hypothyroidism, providing a safe and effective treatment option for millions of hypothyroid patients around the globe. This synthetic form of thyroxine is now one of the most prescribed drugs in the world. Levothyroxine was first introduced by Merck KGaA,Darmstadt, Germany, in 1972, and since then the company has remained actively engaged in research on this mainstay of hypothyroidism treatment. This book is intended for healthcare professionals.
Graves' Orbitopathy
The significant progress in the understanding of the pathogenesis and the treatment of Graves’ orbitopathy (GO) has warranted a second edition of this book within three years of the first. Now also fully incorporated is the EUGOGO consensus statement on management of GO, which since has been accepted worldwide as a useful guideline. Furthermore all chapters have been thoroughly updated. Subjects covered include the pathology of GO and the controversial views on its pathogenesis; assessment of changes using reliable measuring techniques; medical management of GO including established and alternative treatment options; technical explanations and illustrations of various surgical procedures a...
Graves' Orbitopathy
In recent years, close interdisciplinary cooperation of numerous international experts, both clinicians and basic scientists, within the European Group of Graves' orbitopathy (EUGOGO) has yielded much valuable progress and new information, which this publication brings together. Subjects covered include the pathology of Graves' orbitopathy (GO) and the controversial views on its pathogenesis; assessment of changes using reliable measuring techniques; medical management of GO including established and alternative treatment options; technical explanations and illustrations of various surgical procedures and finally, the molecular, immunologic, and clinical aspects of this complex disorder. Str...
DeGroot's Endocrinology, E-Book
Thoroughly updated to reflect today's recent advances in adult and pediatric endocrinology, DeGroot's Endocrinology, 8th Edition, remains the comprehensive, international reference of choice for today's endocrinologists and fellows. A full peer review of the previous edition, conducted by a largely new group of renowned editors, was used to update this trusted, two-volume resource. In-depth coverage of both basic and clinical aspects of endocrinology and up-to-date information on the treatment and management of endocrine disorders are provided by a diverse group of expert contributors from six continents. A full-color format and helpful algorithms summarize clinical decision-making and pract...
Mechanisms and Novel Therapies in Graves’ Orbitopathy: Current Update
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A Case-Based Guide to Clinical Endocrinology
Now in a revised and expanded third edition, this case-based guide emphasizes the latest investigative advances in both imaging and molecular diagnostics and new treatment approaches for a wide variety of common and complex endocrine conditions. Utilizing unique clinical case histories, each main endocrine condition and disorder is curated by a senior Section Editor with an introduction to his or her area covering both physiology and pathophysiology. This introductory chapter is followed by a number of case histories written by invited experts and designed to cover the important relevant pathophysiology, following a consistent chapter format for ease of use, including bulleted objectives, ca...
The Thyroid and Its Diseases
This book is an up-to-date and comprehensive guide to all the common thyroid disorders that may be seen by internists, endocrinologists, nuclear medicine physicians, and endocrine surgeons. While the fundamentals of thyroid hormone function and regulation in health and disease are well covered, the primary focus is on the clinical approach to thyroid disease, with detailed coverage of both initial diagnosis and management and the role of imaging. Because most endocrine diseases are chronic and lifelong, special emphasis is placed on long-term management and the common pitfalls that may be encountered by the clinician. The editors are internationally acknowledged leaders in the field of thyroid disease and have gathered an outstanding team of authors, all of whom are also highly expert in their respective areas, but who, equally importantly, write in a clear and lucid style. The numerous isotope scan and ultrasonographic images ensure that the book will serve as a valuable reference atlas to which the physician will return again and again.
TSH Receptor and Autoimmunity
The present Research Topic aims to provide updated reviews on TSH receptor structure and function, and its relationship with thyroid autoimmunity. Indeed, original reviews deal also with the pathogenesis of Graves' disease and its complications such as thyroid-associated opthalmopathy. Another issue that is addressed in this topic is the multifaceted nature of TSH receptor autoantibodies (TRAbs) and their role in the diagnosis and prognosis of Graves’ disease, with the most recent data on the clinical applications of TRAbs assays. Furthermore, the functional role of the TSH receptor in extrathyroidal tissues is discussed.
Interdisciplinary Management of Orbital Diseases
Interdisciplinary Management of Orbital Diseases: Textbook and Atlas The successful evaluation and treatment of the orbital region-subject to a wide range of diseases affecting multiple organ systems-entails the knowledge and expertise of a multidisciplinary team of specialists. Interdisciplinary Management of Orbital Diseases: Textbook and Atlas brings this team together to offer comprehensive and authoritative discussion of all diseases of the orbital region, with descriptions of topographic and surgical anatomy, pathology, diagnostic steps, imaging, conservative treatment measures, operative approaches, radiotherapy, and orbital reconstruction. Readers will find key information for diagno...
