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Primary Progressive Multiple Sclerosis
"Why are there no effective treatments for my condition? Why do researchers exclude patients with primary progressive multiple sclerosis from enrolling in clinical trials? Please let me know if you hear of studies that I might be allowed to enter or treatments that I could try for my condition. " Thus, in recent years, the sad lament of the patient with primary progressive MS (PPMS). This variant, often in the guise of a chronic progressive myelopathy or, less commonly, progressive cerebellar or bulbar dysfunction, usually responds poorly to corticosteroids and rarely seems to benefit to a significant degree from intensive immunosuppressive treatments. In recent years, most randomized clin i...
Immune Rebalancing
Immune Rebalancing: The Future of Immunosuppression summarizes the most promising perspectives of immunopharmacology, in particular in the area of immunosuppression by considering molecular pathways, personalized medicine, microbiome and nanomedicine. Modulation of immune responses for therapeutic purposes is a particularly relevant area, given the central role of anomalous immunity in diseases. These diseases vary from the most typically immune-related syndromes (autoimmune diseases, allergy and asthma, immunodeficiencies) to those in which altered immunity and inflammation define the pathological outcomes (chronic infections, tumours, chronic inflammatory and degenerative diseases, metabol...
Functional Rehabilitation of Some Common Neurological Conditions
A kinematic motor organisation which is crucial for performing different functional tasks is mediated by a distinct motor functional architecture of the central nervous system. A breakdown of this architectural network occurs in most neurological condition with motor impairment. Therefore a planned physical intervention to restore impaired structure architectural network of the brain is essential for the functional recovery. This book has dealt with four common conditions and for each condition it has identified structure of architectural network is damaged. Then the intervention strategy has elaborated the some of the precisely shaped stimulation that can restore the impaired structure, which has used wide range of research based evidences.
Multiple Sclerosis Therapeutics
This textbook examines the most important aspects of multiple sclerosis that impact on clinical trial design, on the development of new disease therapies and on patient care. The international team of contributors discuss the clinical course of multiple sclerosis, its clinical heterogeneity, the presence of subclinical disease activity which occurs during the early stages of the disease. Multiple sclerosis presents clinical challenges: from unexpected and irregular relapses to profressive deterioration.
Neurodegeneration in Multiple Sclerosis
Written by world-renowned scientists, the volume provides a state-of-the-art on the most recent MRI techniques related to MS, and it is an indispensable tool for all those working in this field. The context in which this book exists is that there is an increasing perception that modern MR methodologies should be more extensively employed in clinical trials to derive innovative information.
Understanding the Roles of Glia and Circulating Leukocytes in Neurodegenerative Diseases
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Biological Network Analysis
Biological Network Analysis: Trends, Approaches, Graph Theory, and Algorithms considers three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN), and Human Brain Connectomes. The book's authors discuss various graph theoretic and data analytics approaches used to analyze these networks with respect to available tools, technologies, standards, algorithms and databases for generating, representing and analyzing graphical data. As a wide variety of algorithms have been developed to analyze and compare networks, this book is a timely resource.
Magnetic Resonance Techniques in Clinical Trials in Multiple Sclerosis
We have entered an exciting period in the study of multiple sclerosis and its treatment. Central to this progress has been the introduction of magnetic reso nance techniques. When Young and his colleagues published the first images of the brain in multiple sclerosis at the end of 1981, it was at once obvious that magnetic resonance imaging would playa major role in diagnosis. Intuitively one felt that it would also have a role in increasing our understanding of the pathogenesis of the disease and in monitoring treatment. And so it has proved. Important problems however remain, perhaps the most important of which at present is the weak predictive power of standard magnetic resonance ima ging ...
Neurological and Neuropsychiatric Disorders Affecting Military Personnel and Veterans
Active military personnel and Veterans of the military face unique neurologic and neuropsychiatric challenges unique to this population compared to the public. The military and Veteran population have faced traumatic experiences that lead to both physical and mental consequences. Amongst the important challenges unique to this population include traumatic brain injury, increased risk of neurological disorders such as dementia and stroke, and comorbid neuropsychiatric conditions. Unfortunately, many of these challenges also have a negative feedback loop such as brain injuries leading to post-traumatic stress order, which can increase risk of Alzheimer’s Dementia. Unfortunately, there are ma...
