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The new novel from the best-selling author of I Don’t Know How She Does It takes us on an unforgettable journey into first love, and—with the emotional intensity and penetrating wit that have made her beloved among readers all over the world—reminds us of how the ardor of our youth can ignite our adult lives. Wales, 1974. Petra and Sharon, two thirteen-year-old girls, are obsessed with David Cassidy. His fan magazine is their Bible, and some days his letters are the only things that keep them going as they struggle through the humiliating daily rituals of adolescence—confronting their bewildering new bodies, fighting with mothers who don’t understand them at all. Together they tack...
S. Ren and E.J. Lien: CaCo-2 cell permeability vs human gastrointestinal absorption: QSPR analysis.- J.C.G. Halford and J.E. Blundell: Pharmacology of appetite suppression.- B. Olivier, W. Soudijn and I. van Wijngaarden: Serotonin, dopamine and norepinephrine transporters in the central nervous system and their inhibitors.- D. Poyner, H. Cox, M. Bushfield, J.M. Treherne and M.K. Demetrikopoulos: Neuropeptides in drug research.- M. Kumari and M.K. Ticku: Regulation of NMDA receptors by ethanol.- H. Horikoshi, T. Hashimoto and T. Fujiwara: Troglitazone and emerging glitazones: new avenues for potential therapeutic benefits beyond glycemic control.- Rosamund C. Smith and Simon J. Rhodes: Applications of developmental biology to medicine and animal agriculture.
Progress in Drug Research is a prestigious book series which provides extensive expert-written reviews on a wide spectrum of highly topical areas in current pharmaceutical and pharmacological research. It serves as an important source of information for researchers concerned with drug research and all those who need to keep abreast of the many recent developments in the quest for new and better medicines.
The first section of this volume is aimed to provide a comprehensive review of the many varied and often empirically derived techniques and procedures currently in use to produce monoclonal hybridoma cell lines and to characterize the antibodies secreted. The goal has been achieved with the chapter contributed by Zola and Brookes who, as each step in the process of hybridoma production and antibody characterisation is reviewed, have provided an experimental procedure found to be satisfactory in their laboratory.The second section of this volume is designed to provide a review of areas in which monoclonal hybridoma antibodies have been of particular advantage. This is a rapidly advancing field which could not be thoroughly reviewed in a single volume.
The Oxford Companion to Food by Alan Davidson, first published in 1999, became, almost overnight, an immense success, winning prizes and accolades around the world. Its combination of serious food history, culinary expertise, and entertaining serendipity, with each page offering an infinity of perspectives, was recognized as unique. The study of food and food history is a new discipline, but one that has developed exponentially in the last twenty years. There are now university departments, international societies, learned journals, and a wide-ranging literature exploring the meaning of food in the daily lives of people around the world, and seeking to introduce food and the process of nouri...
Understanding the nature and role of endothelium-derived hyperpolarizing factor is crucial in the quest for improved treatments for hypertension, diabetes, ischemia-reperfusion, and other vascular disorders. EDHF 2002 is based on the proceedings of the Fourth International Symposium on endothelium-dependent hyperpolarizations. It will be of interest not only to physiologists and pharmacologists puzzled by the complexity of the interactions between the endothelium and underlying vascular smooth muscle cells, but also clinical researchers and physicians treating patients with cardiovascular diseases.
This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we...
From the contents: A- C. Brater and M. D. Murray: The effects of NSAIDs on the kidney A- G. Edwards and A. H. Weston: Latest developments in potassium channel modulator drugs A- M.R. Juchau and Y. Huang: Chemical teratogenesis in humans: Biochemical and molecular mechanisms A- S.P. Gupta: Studies on cardiovascular drugs A- G. Polak: Antifungal chemotherapy: An everlasting battle A- O. Valdenaire: New insights into the bioamine receptor family