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Alkylating Agents As Environmental Carcinogen and Chemotherapy Agents
Alkylating agents are an important class of carcinogens. O6-methylguanine (O6 MG) formed in cellular DNA by alkylating agents is a mutagenic lesion. Reactive metabolites, which are capable of alkylate in the DNA base, are produced during the catabolism of precursors of alkylating agents in the diet. Active alkylating agents can also be synthesised endogenously in the body. Endogenous alkylating agents are produced via nitrosation of primary amines by nitrates and nitrous anhydride formed by nitric oxide. Exposure of alkylating agents is at a minimum level in daily life. On the other hand, alkylating agents are used in certain chemotherapy regimens. Various investigators determined that O6-MG...
Advances in Prostaglandin, Leukotriene, and other Bioactive Lipid Research
This volume, the Proceedings of the 12th International Conference on Advances in Prostaglandin, Leukotriene and Other Bioactive Lipid Research: Basic Science and Clinical Applications, held August 25-29, 2002, in Istanbul, Turkey, discusses advances in bioactive lipid research with special attention to cancer, cardiovascular diseases, gastrointestinal diseases and respiratory diseases. Specific topics covered include the role of leukotrienes and lipoxins in inflammation, the cytochrome P450 pathway, the genetics and genomics of bioactive lipids, lipid peroxidation, apoptosis, angiogenesis, isoprostanes, receptors and inhibitors, cyclooxygenase and lipoxygenase pathways and inhibitors, prostaglandin synthases and receptor signaling, phospholipases and inhibitors.
Dynamics of Structures
The book is an excellent text as well as a practical reference for civil, mechanical and aerospace engineers and has been identified as a work that is admirable in its lucidity and complete in itself. A unique feature of the text is its special emphasis on the application of numerical methods in the analysis of discrete systems. It provides coverage of both the traditional and state-of-the-art numerical techniques of response analysis, such as analysis by numerical integration of the equations of motion and analysis through frequency domain. A large number of solved examples and exercise problems add to clarity and reader comprehension.
Modernization and British Colonial Rule in Egypt, 1882-1914
In occupied Egypt, British governmental programs were closely related to England's needs as an imperial power since Egypt was occupied because of its strategic position along the route to India. British presence there, however, inevitably led to modernization during the 32 years of British rule. During the first period the British were preoccupied with the prospect of imminent withdrawal. The second period emphasized programs for such reforms as hydraulic and agricultural modernization, wider education, and urban development. The final period covered the emergence of Egyptian nationalism, whose goals proved incompatible with British rule of Egypt in spite of efforts to deal with nationalism ...
The Economics of the Roman Stone Trade
Russell provides an examination of the production, distribution, and use of carved stone objects in the Roman world. Focusing on the market for stone and its supply, he offers an assessment of the practicalities of stone transport and how the relationship between producer and customer functioned even over considerable distances.
Engineering Decision Making and Risk Management
IIE/Joint Publishers Book of the Year Award 2016! Awarded for ‘an outstanding published book that focuses on a facet of industrial engineering, improves education, or furthers the profession’. Engineering Decision Making and Risk Management emphasizes practical issues and examples of decision making with applications in engineering design and management Featuring a blend of theoretical and analytical aspects, this book presents multiple perspectives on decision making to better understand and improve risk management processes and decision-making systems. Engineering Decision Making and Risk Management uniquely presents and discusses three perspectives on decision making: problem solving,...
Biomedical Engineering Fundamentals
Known as the bible of biomedical engineering, The Biomedical Engineering Handbook, Fourth Edition, sets the standard against which all other references of this nature are measured. As such, it has served as a major resource for both skilled professionals and novices to biomedical engineering. Biomedical Engineering Fundamentals, the first volume of the handbook, presents material from respected scientists with diverse backgrounds in physiological systems, biomechanics, biomaterials, bioelectric phenomena, and neuroengineering. More than three dozen specific topics are examined, including cardiac biomechanics, the mechanics of blood vessels, cochlear mechanics, biodegradable biomaterials, soft tissue replacements, cellular biomechanics, neural engineering, electrical stimulation for paraplegia, and visual prostheses. The material is presented in a systematic manner and has been updated to reflect the latest applications and research findings.
Intelligent Techniques in Engineering Management
This book presents recently developed intelligent techniques with applications and theory in the area of engineering management. The involved applications of intelligent techniques such as neural networks, fuzzy sets, Tabu search, genetic algorithms, etc. will be useful for engineering managers, postgraduate students, researchers, and lecturers. The book has been written considering the contents of a classical engineering management book but intelligent techniques are used for handling the engineering management problem areas. This comprehensive characteristics of the book makes it an excellent reference for the solution of complex problems of engineering management. The authors of the chapters are well-known researchers with their previous works in the area of engineering management.
Designing Embedded Systems with PIC Microcontrollers
Embedded Systems with PIC Microcontrollers: Principles and Applications is a hands-on introduction to the principles and practice of embedded system design using the PIC microcontroller. Packed with helpful examples and illustrations, the book provides an in-depth treatment of microcontroller design as well as programming in both assembly language and C, along with advanced topics such as techniques of connectivity and networking and real-time operating systems. In this one book students get all they need to know to be highly proficient at embedded systems design. This text combines embedded systems principles with applications, using the16F84A, 16F873A and the 18F242 PIC microcontrollers. S...
Biology for Engineers
Biology is a critical application area for engineering analysis and design, and students in engineering programs must be well-versed in the fundamentals of biology as they relate to their field. Biology for Engineers is an introductory text that minimizes unnecessary memorization of connections and classifications and instead emphasizes concepts, technology, and the utilization of living things. Whether students are headed toward a bio-related engineering degree or one of the more traditional majors, biology is so important that all engineering students should know how living things work and act. Classroom-tested at the University of Maryland, this comprehensive text introduces concepts and ...
