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Individualized Medicine
In 2009 the University Medicine Greifswald launched the “Greifswald Approach to Individualized Medicine” (GANI_MED) to implement biomarker-based individualized diagnostic and therapeutic strategies in clinical settings. Individualized Medicine (IM) has led not only to controversies about its potentials, but also about its societal, ethical and health economic implications. This anthology focusses on these areas and includes – next to clinical examples illustrating how the integrated analysis of biomarkers leads to significant improvement of therapeutic outcomes for a subgroup of patients – chapters about the definition, history and epistemology of IM. Additionally there is a focus on conceptual philosophical questions as well as challenges for applied research ethics (informed consent process, the IT-based consent management and the handling of incidental findings). Finally it pays attention to health economic aspects. The possibilities of IM to initiate a paradigm shift in the German health care provision are investigated. Furthermore, it is asked whether the G-DRG system is ready for the implementation of such approaches into clinical routine.
Apheresis in Neurological Disorders
Apheresis refers to an extracorporeal therapy which aims at removing pathological constituents from the patients’ blood. Due to the development of new techniques as well as the discovery of novel autoimmune antibodies, it is increasingly recognized as an important therapeutic option for a variety of autoimmune-mediated neurological disorders, including multiple sclerosis, myasthenia gravis, autoimmune encephalitis, Guillain–Barré syndrome, and many others. Therapeutic plasma exchange (TPE) constitutes the standard method of apheresis for most indications, while immunoadsorption (IA) offers a more specific, low-risk alternative. Both methods aim at removing auto-antibodies from the blood. Evidence for most neurological diseases is still low. Interestingly, more recent developments suggest that apheresis is not limited to the removal of autoantibodies but may also be useful in neurodegenerative and possibly even in acute vascular disorders.
Somatoform Disorders
Be Guided by the Evidence... Somatoform disorders are more common than many clinicians realize and are often underdiagnosed and poorly managed. This practical guide provides a comprehensive overview of all somatoform disorders. It aims to enable the mental health practitioner to properly diagnose and manage the disorders as well as to provide the appropriate advice to colleagues of other medical disciplines. Somatoform Disorders offers: * Detailed coverage of the concepts of each disorder: diagnosis, classification, co-morbidities and course and outcome * An outline of clinical, biological and psychosocial research in the area * An overview of clinical management and future perspectives * The unique series format of systematic reviews followed by commentaries Somatoform Disorders is the ninth volume of the WPA Series "Evidence and Experience in Psychiatry. The book is an unbiased and reliable reference point for all psychiatrists, psychologists, mental health nurses and policy makers.
Nutrition and Prevention of Alzheimer's Disease
Altered metabolism is known to be associated with a higher incidence of Alzheimer´s disease (AD). Diabetes type 2, obesity, and metabolic syndrome are considered risk factors for the development of dementias, including AD. These metabolic diseases may have a genetic predisposition, but most of them are caused by environmental factors and life-style. Most research has focused on the effect of a high-fat diet (HFD) and sweetened beverages that induce obesity. Importantly, a HFD can also trigger oxidative stress, neuro-inflammation and cognitive decline. Less is known, however, about beneficial effects of diet on cognition, such as slowing the progression or preventing AD by ingesting whole fr...
Action, Embodied Mind, and Life World
Action, Embodied Mind, and Life World combines embodied consciousness research, existential phenomenology, Gendlin's "focusing" concept, and recent self-organizational work on basic emotions (e.g., Panksepp, Frijda), to explore the way patterns of motivated action shape our interpretations of reality—personally, biologically, and within a sociopolitical community. Like a bat projecting sonar, we understand our world by sensing patterns of resistance against our own self-initiated actions. If hammering is the action, we find "nails" and "non-nails." Actions in turn express a self-organizing process rooted in motivational structures that presuppose values. These patterns of motivation theref...
The Palgrave Handbook of Volunteering, Civic Participation, and Nonprofit Associations
Written by over 200 leading experts from over seventy countries, this handbook provides a comprehensive, state-of-the-art overview of the latest theory and research on volunteering, civic participation and nonprofit membership associations. The first handbook on the subject to be truly multinational and interdisciplinary in its authorship, it represents a major milestone for the discipline. Each chapter follows a rigorous theoretical structure examining definitions, historical background, key analytical issues, usable knowledge, and future trends and required research. The nine parts of the handbook cover the historical and conceptual background of the discipline; special types of volunteeri...
Personalized Psychiatry
Personalized Psychiatry presents the first book to explore this novel field of biological psychiatry that covers both basic science research and its translational applications. The book conceptualizes personalized psychiatry and provides state-of-the-art knowledge on biological and neuroscience methodologies, all while integrating clinical phenomenology relevant to personalized psychiatry and discussing important principles and potential models. It is essential reading for advanced students and neuroscience and psychiatry researchers who are investigating the prevention and treatment of mental disorders. - Combines neurobiology with basic science methodologies in genomics, epigenomics and transcriptomics - Demonstrates how the statistical modeling of interacting biological and clinical information could transform the future of psychiatry - Addresses fundamental questions and requirements for personalized psychiatry from a basic research and translational perspective
