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Nutrition and Kidney Disease
It is well-known that the daily diet plays an important role in the preservation and integrity of renal function in patients with chronic kidney disease. However, there currently exists some confusion as to the right diet because of the MDRD (Modification of Diet in Renal Disease) study, which has shown that a low-protein diet does not have a major effect on the course of renal dysfunction. To resolve this dilemma, researchers are developing a framework for an appropriate dietary program which will significantly alter the understanding of the role of diet and, eventually, have important implications for the practice of nephrology. This publication provides an update on both laboratory and cl...
Acute Blood Purification
Acute organ damage and the ensuing multiple organ failure are the result of a pathophysiological process involving various cytokines. Once activated, these proteins cannot be eliminated even when the kidneys function at their maximum capacity. To counteract this mechanism, researchers in Japan have developed an innovative concept employing blood purification to remove the overwhelming cytokines. This book describes the use of hemodiafiltration to inhibit the cytokine storms which cause serious organ damage in patients with septic shock. Moreover, the technical construction of the blood purification system, which includes various machines, devices, membranes, fluids, etc., is explained in detail. Finally, leading experts discuss the concept of continuous renal replacement therapy as the standard care in critically ill patients with severe acute kidney injury. Describing the current state of acute blood purification, this publication provides new impulses and opens new avenues in the treatment of acute organ damage.
Kidney and Blood Pressure Regulation
Chronic kidney disease is one of the world's major public health problems, and the prevalence of kidney failure is rising steadily. Among the risk factors for a faster progression of renal disease are hypertension and proteinuria, many studies clearly demonstrating that hypertension is both a cause and consequence of chronic kidney disease. Namely, renal blood pressure regulation seems to be involved in five major pathophysiological mechanisms (all closely related to the renin-angiotensin system): Pressure-natriuresis, renal sympathetic nervous system, renal blood flow, intraglomerular pressure and tubuloglomerular feedback. This book reviews experimental data which form the basis of our cur...
Home Dialysis in Japan
Presenting the latest advances in research and clinical care Despite the various advantages of home dialysis compared to in- center hemodialysis, only a fraction of patients in Japan currently opt for peritoneal dialysis or home hemodialysis. However, considerable advances in research and technical improvements have been made lately, advancing the practice of home dialysis therapy in Japan. Japanese research is well-known for its ingenuity and creative energy with regard to the development of new machines and systems for dialysis. New insights regarding peritoneal dialysis and home hemodialysis are presented in the publication at hand: Contributions by leading Japanese experts discuss topics such as educational methods, techniques, tools, novel systems and organization of patients. The book will be of great interest to clinical physicians involved in dialysis care; Moreover, the expertise collected in this volume may contribute to the advancement of home dialysis therapy in a global context.
CCN proteins in health and disease
The CCN family of genes currently comprises six secreted proteins (designated CCN16 i.e., Cyr61/CCN1; ctgf/CCN2; Nov/CCN3; WISP1/CCN4; WISP2/CCN5, and WISP3/CCN6) showing a strikingly conserved primary structure, with four modules sharing partial identity with IGF binding proteins, Von Willebrand protein, thrombospondin and several matricellular proteins and growth factors. The current view is that CCN proteins modulate signaling pathways that involve regulatory components of the extracellular matrix. As such, they likely act as a central hub in the regulation of mitosis, adhesion, apoptosis, extracellular matrix production, growth arrest and migration of multiple cell types. The 5th interna...
Updates in Hemodialysis
In this special issue, reviews of various aspects of HD therapy were submitted from all over the world. In particular, reviews for recent advances in this area from leading experts have been contributed to the book Hemodialysis. In order to deliver optimal patient care, nephrologists need to understand and be highly knowledgeable in the mechanisms of multiple aspects of hemodialysis therapy. Moreover, this book will provide an important source of information for beginners and experts, basic scientists and physicians who want to have a true update on current clinical practice in hemodialysis.
Official Gazette of the United States Patent and Trademark Office
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