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Acute inflammation is a highly regulated process, and its dysregulation can lead to the development of a chronic inflammatory state which is believed to play a main role in the pathogenesis of many diseases, including cancer. In recent years, the need to find new anti-inflammatory molecules has raised the scientific community´s interest for marine natural products. In this regard, the marine environment represents a source for isolating a wealth of bioactive compounds. In this Special Issue, the reported products have been obtained from microalgae, sea cucumber, octopus, squid, red alga-derived fungus, cnidarians, hard-shelled mussel, and sponges. This Special Issue of Marine Drugs covers b...
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Platelets, Fourth Edition, integrates the entire field of platelet biology, pathophysiology, and clinical medicine with contributions from 142 world experts from 18 countries. This award-winning reference provides clear presentations by basic scientists on the cellular, molecular, and genetic mechanisms of platelets and the role of platelets in thrombosis, hemorrhage, inflammation, antimicrobial host defense, wound healing, angiogenesis and cancer. It also provides start-of-the-art presentations by hematologists, cardiologists, stroke physicians, blood bankers, pathologists and other clinicians on platelet function testing, disorders of platelet numbers and function, antiplatelet therapy and...
This first comprehensive guide to the novel field of gene therapy in the skin provides insight into the basic principles and methods of gene transfer into the skin and its applications. It enables the understanding of possibilities and implications such as immunization and treatment as well as safety aspects. Gene therapy in dermatology is the avantgarde of a new field in science with a great future for human health.
THE "LITTLE ICE AGE": LOCAL AND GLOBAL PERSPECTIVES P. D. JONES and K. R. BRIFFA Climatic Research Unit, University of East Anglia, Norwich, NR4 7TJ, UK. This volume of Climatic Change is devoted to the study of the climate of the last 1000 years, with a major emphasis on the last few centuries. The timespan encompasses what has been referred to as the "Little Ice Age" (Bradley, 1992). This term was originally coined by glaciologists, with reference to the most recent major glacial advance of the Holocene (Bradley and Jones, 1993). Although other such advances in different parts of the world may not have been synchronous, the term "Little Ice Age" has come to be associated with the period of a widespread foreward movement of European glaciers between about 14 50 to 1850, as well as with relatively cooler temperatures. The issue of whether or not this concept is appropriate, is a major theme of many of the papers included in this volume.
This book is the first comprehensive overview and evaluation of the origins, history and current size and condition of all of Iceland's major glaciers (including Vatnajökull, the largest in Europe) at the beginning of the twenty-first century. It is not only illustrated with many beautiful photographs and graphs of recent statistics and scientific data, but is also a collection of historical writings and drawings from annals, sagas, folk tales, diaries, reports, stories and poems, as it presents a unique approach to the study of glaciers on an island in the North Atlantic. Balancing and comparing the world of man with the world of nature, the perceptions of art and culture with the systemat...
European Glacial Landscapes: The Holocene presents the current state of knowledge on glacial landscapes of Europe and nearby areas over the Holocene to deduce the influence of atmospheric and oceanic currents and the insolation forcing variability and volcanic activity on Holocene paleoclimates, the existence of asynchronies in the timing of occurrence of glacier expansion and shrinkage during the Holocene, time lags between the identification of oceanic and atmospheric changes and those occurring in glacial extension during the Holocene, the role of Holocene glaciers on the climate of Europe, and on sea level variability, and the delimitation of landscapes that need special protection. Stud...
This book is a contribution to the International Year of Planet Earth arising from the 33rd International Geological Congress, held in Oslo, Norway during August 2008. The first section of the book considers aspects of geochemical processes which led to the development of the solid Earth as it is today. The second portion of the book shows how the rapidly-evolving analytical tools and approaches presently used by geochemists may be used to solve emerging environmental and other societal problems. This unique collection of reviews, with contributions from a range of internationally distinguished scientists, will be invaluable reading for advanced students and others interested in the central role geochemistry in the earth sciences.