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Epigenetics of Aging
Recent studies have indicated that epigenetic processes may play a major role in both cellular and organismal aging. These epigenetic processes include not only DNA methylation and histone modifications, but also extend to many other epigenetic mediators such as the polycomb group proteins, chromosomal position effects, and noncoding RNA. The topics of this book range from fundamental changes in DNA methylation in aging to the most recent research on intervention into epigenetic modifications to modulate the aging process. The major topics of epigenetics and aging covered in this book are: 1) DNA methylation and histone modifications in aging; 2) Other epigenetic processes and aging; 3) Impa...
Methylation
Alterations in the normal DNA methylation processes are known to have major consequences for embryonic development and are associated with congenital defects, autoimmunity, aging and malignant transformation. The main purpose of this book is to provide information about the importance of methylation mechanisms in human health and disease. The book, covers the basic mechanism of DNA and protein methylation, aiming at the advanced undergraduate and graduate biomedical students and researchers working in the epigenetic area. The textbook chapters provide background as well as advanced information in the methylation area. On the other hand, it provide readers with both classical and relevant recent discoveries that have been made in the field, pointing out pathways where questions remain.
Alternative Cementitious Materials for Self-Compacting Concrete
With the current emphasis on sustainable construction there is now a move towards using non-hazardous waste materials and by-products, as binders in making self-compacting concrete. Alternative Cementitious Materials for Self-Compacting Concrete provides a detailed review on the various properties of self-compacting concrete (SCC) and how they are affected by the use, of by-products and waste materials in concrete production. The book provides a fair comparison on the application and use of various types of materials in SCC. It also provides the latest data and detailed information on modeling and soft computing techniques for estimation of the various properties of SCC as well as detailed i...
Cotton and Flax Fibre-Reinforced Geopolymer Composites
This book provides an overview on the latest advances in the synthesis, properties and applications of geopolymers reinforced with natural fibres such as pulp fibre, cotton, sisal, flax and hemp. The influence of adding various natural fibres and nanofillers on the mechanical properties of these composites is discussed. Potential challenges and future directions of these composites are highlighted and addressed. The content of this book caters to students, researchers and academics who are interested in the synthesis and applications of geopolymers composites.
Computational Modelling of Concrete Structures
The EURO-C conference series (Split 1984, Zell am See 1990, Innsbruck 1994, Badgastein 1998, St Johann im Pongau 2003, Mayrhofen 2006, Schladming 2010, St Anton am Alberg 2014) brings together researchers and practising engineers concerned with theoretical, algorithmic and validation aspects associated with computational simulations of concrete and
Epigenetics Protocols
The field of epigenetics has grown exponentially in the past decade, and a steady flow of exciting discoveries in this area has served to move it to the forefront of molecular biology. Although epigenetics may previously have been considered a peripheral science, recent advances have shown considerable progress in unraveling the many mysteries of nontraditional genetic processes. Given the fast pace of epigenetic discoveries and the groundbreaking nature of these developments, a thorough treatment of the methods in the area seems timely and appropriate and is the goal of Epigenetics Protocols. The scope of epigenetics is vast, and an exhaustive analysis of all of the techniques employed by i...
Leveraging Biomedical and Healthcare Data
Leveraging Biomedical and Healthcare Data: Semantics, Analytics and Knowledge provides an overview of the approaches used in semantic systems biology, introduces novel areas of its application, and describes step-wise protocols for transforming heterogeneous data into useful knowledge that can influence healthcare and biomedical research. Given the astronomical increase in the number of published reports, papers, and datasets over the last few decades, the ability to curate this data has become a new field of biomedical and healthcare research. This book discusses big data text-based mining to better understand the molecular architecture of diseases and to guide health care decision. It will...
Micro and Nanostructured Composite Materials for Neutron Shielding Applications
Micro- and Nanostructured Composite Materials for Neutron Shielding Applications presents recent developments and future possibilities for neutron shielding materials. Emphasis is placed on the correlation between the morphology, shielding mechanisms, and other desired properties, including their mechanical and thermal properties. The effect of neutron absorbing fillers, including their size on final properties is also examined, as are recent advancements in preparation, characterization and simulation techniques. Written by specialists in their respective fields, this comprehensive resource will help professionals and students understand the fundamentals of neutron shielding, as well as the properties of micro- and nanopolymer-based composites, concrete materials, alloy materials and metal-ceramic composites. - Provides an up-to-date understanding of the fundamentals of shielding mechanisms, morphology and material property correlations - Covers a broad range of micro and nano composite materials for neutron shielding - Discusses recent advances surrounding the synthesis and processing of nanostructures and nanocomposite materials
