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Neuronal Man
Over the past thirty-five years, there has been an explosive increase in scientists' ability to explain the structure and functioning of the human brain. While psychology has advanced our understanding of human behavior, various other sciences, such as anatomy, physiology, and biology, have determined the critical importance of synapses and, through the use of advanced technology, made it possible actually to see brain cells at work within the skull's walls. Here Jean-Pierre Changeux elucidates our current knowledge of the human brain, taking an interdisciplinary approach and explaining in layman's terms the complex theories and scientific breakthroughs that have significantly improved our understanding in the twentieth century.
Nicotinic Acetylcholine Receptors
The acetylcholine nicotinic receptor is among the most studied receptors in neuroscience. Involved in muscle contraction and a wide variety of other neurological functions, including the processing of nicotine, it was the first receptor to be isolated and observed at the molecular level, providing a major research pathway for scientists working in neuroscience, biochemistry, pharmacology, and behavioral science. This book describes four decades of scientific research that inform our current understanding of this receptor. Jean-Pierre Changeux and Stuart J. Edelstein played important roles in pioneering research on the acetylcholine nicotinic receptor and on allosteric proteins, and here they...
Epigenetics, Brain and Behavior
What lies at the heart of neuronal plasticity? Accumulating evidence points to epigenetics. This word originally indicated potentially heritable modifications in gene expression that do not involve changes in DNA sequence. Today this definition is much less strict, and epigenetic control is thought to include DNA methylation, histone modifications, histone variants, microRNA metabolic pathways and non-histone proteins modifications. Thus, while neuronal plasticity is rightly thought to be intimately associated to genomic control, it is critical to appreciate that there is much more to the genome than DNA sequence. Recent years have seen spectacular advances in the field of epigenetics. These...
Cellular and Molecular Control of Direct Cell Interactions
The NATO Advanced Study Institute on "Cellular and Molecular Control of Direct Cell Interactions in Developing System" has been attended by 15 invited main lecturers and 60 participants. According to its purpose senior scientists, postdoctoral trainees and graduate students working in areas like biology, biochemistry, electrophysiology, medicine etc . . . could discuss their common interest in the various structural, ultrastructural, molecular and functional aspects of cell interactions in developing in vivo and in vitro systems. Whereas the topics of the first week have been mostly concerned with the general aspects of cell interactions in embryogenesis (section I and II of this book), the ...
The Newborn Brain
The new edition of this respected work presents a comprehensive review of basic mechanisms of fetal and neonatal brain development.
Receptors
Advances in Pharmacology and Therapeutics, Volume l: Receptors contains the proceedings of the 7th International Congress of Pharmacology held in Paris, France, in 1978. The papers explore advances in the understanding of receptors, their pharmacology, and their therapeutic applications. Topics covered range from opiate receptors and their endogenous ligands to membrane receptors in eukaryotic cells. Applications of binding to pharmacological research are also discussed. This volume is comprised of 29 chapters and opens with an overview of the chemistry and biochemistry of pituitary endorphins, paying particular attention to the correlation between the analgesic potency, receptor binding pro...
Snake Venoms
The past decade has been a period of explosion of knowledge on the chemistry and pharmacology of snake toxins. Thanks to the development of protein chemistry, nearly a hundred snake toxins have been purified and sequenced, representing one of the largest families of sequenced proteins. Moreover, the mode of action of these toxins has been largely elucidated by the concerted efforts of pharmacologists, electro physiologists, and biochemists. As a result of these studies, some of the snake toxins, e.g., a-bungarotoxin and cobra neurotoxins, have been extensively used as specific markers in the study of the acetylcholine receptors. Indeed, without the discovery of these snake toxins, our knowle...
Membrane Proteins: Structures, Interactions and Models
The 25th Jerusalem Symposium represents a most significant highlight in the development and history of these meetings. Living within the decimal system we have celebrated with much pleasure the lath and the 20th Jerusalem Symposia. With this one we experience a feeling of particular satisfaction because 25 years is different from, is more than, two decades and a half. It is a quarter of a century. It seems thus as if we have changed the dimension of our endeavour. In no way do we loose the sense of modesty with respect to the significance of these meetings. For the organizers, however, they do represent a continuity of efforts which we feel happy to have been able to carry out. At this occasion it seems useful to say a few words about the origin of the Jerusalem Symposia and to recall the name of a colleague who played an essential role in their creation and has been a most efficient and devoted co organizer of the seven first of them. This was Professor Ernst Bergmann, one of the most distinguished founders of Israeli Science and a world famous physico-organic chemist.
The Cambridge Handbook of Cognitive Development
This handbook presents a cutting-edge overview of cognitive development, spanning methodology, key domain-based findings and applications.
Proceedings of the Taniguchi Symposia on Brain Sciences, Volume 10: Strategy and Prospects in Neuroscience
This book deals with molecular neurobiology based on neurochemical approaches and focuses on neural plasticity studied by neurophysiological methods. It offers discussions on prospects of neuroscience from the respective stances of the participants.
