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Filaggrin
Filaggrin gene mutations are common in Europeans and their descendants, as well as in Asians, reaching a prevalence of up to 10%. Filaggrin proteins are crucial for skin homeostasis as their metabolites maintain skin hydration, keep the skin pH low, and provide protection against solar radiation. FLG mutation carriers suffer from dry and scaly skin and have an increased transfer of allergens and chemicals across the epidermis. Moreover, they have 10% higher serum vitamin D levels, potentially affecting the propensity to develop other diseases. FLG loss-of-function mutations represent the strongest risk factor hitherto discovered for atopic dermatitis and are major predisposing factors for related asthma and hay fever. This textbook provides comprehensive and detailed coverage of the effects of FLG mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas.
Textbook of Hand Eczema
Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The "Textbook of Hand Eczema" reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.
Quick Guide to Contact Dermatitis
This book is a quick guide for clinicians, specialists, and residents. It provides a concise overview of the practical aspects of contact dermatitis, supplying the tools to allow a fast and reliable diagnosis. The book describes the clinical features of contact dermatitis, explains how to make an exposure assessment and covers other essentials in the diagnostic work. Information is presented on testing with patients’ own products and overviews are provided on the allergens contained in various products. In addition, a helpful list of the most frequent allergens is included. The authors are leading practitioners in the field, and their expertise has enabled the compilation of an approachable text supplemented by a large number of full color illustrations, tables and check lists. This book will help the reader to gain a better understanding of the subject and to achieve greater competence in everyday practice.
Metal Allergy
This volume opens by providing a comprehensive overview of the use and regulation of metals in our society, metal properties, and available testing methodologies. Common and uncommon metal allergens and sources of exposure are then reviewed in depth, detailing allergic responses and paying special consideration to select patient populations. In the general population, the prevalence of metal allergy is high. Environmental sources of metal exposure include jewelry, clothing, electronic devices, coins, leather, diet, and occupational exposure. Metal allergy may result in allergic contact dermatitis and systemic contact dermatitis, as well as several less common manifestations. Further, metal allergy has been associated with device failure and/or dermatitis following implantation of medical devices and dental implants. As metals are ubiquitous, this book will be indispensable for a wide range of clinicians and investigators. This handy reference will meet the needs of all health professionals and investigators who are interested in metal allergy and its diagnosis and management.
Dermatotoxicology
The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international ex
Treatment of Dry Skin Syndrome
Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
Contact Urticaria Syndrome
Contact urticaria syndrome was first defined in 1975 and since then scientific interest has steadily increased. New cases are continuously being reported furnishing information on novel clinical features. A large number of compounds could be responsible for triggering the syndrome including fragrances, cosmetics, latex, preservatives, flavorings, and disinfectants. However, contact urticaria syndrome is often misdiagnosed in part due to a misinterpretation of its clinical manifestation and lack of knowledge of appropriate testing protocols and diagnostic programs. The latter have to be individualized for each patient based on the substance in question, medical history, possible concomitant d...
Atopic Dermatitis, An Issue of Dermatologic Clinics
This issue of Dermatologic Clinics, guested edited by Drs.Jonathan I. Silverberg and Nanette Silverberg, is devoted to Atopic Dermatitis. Articles in this outstanding issue include: How to Define Atopic Dermatitis; Public Health Burden and Epidemiology of Atopic Dermatitis; Long-term Course of Atopic Dermatitis; Allergic and Non-Allergic Comorbidities of Atopic Dermatitis; Patient-burden of Atopic Dermatitis; Assessment of Atopic Dermatitis Severity in Clinical Practice; An Update on the Pathophysiology of Atopic Dermatitis; Long-term Treatment of Atopic Dermatitis; Special Considerations for Management of Atopic Dermatitis in Young Children; Management of Adult Onset Atopic Dermatitis; Management of Atopic Hand Dermatitis; Adjunctive Management of Itch in Atopic Dermatitis; and Racial and Ethnic Differences of Atopic Dermatitis.
The Baby and the Biome
A revolutionary parenting book that draws on cutting-edge research to reveal that the key to raising happy and healthy babies lies in carefully protecting and caring for their microbiomes. A baby’s immune system develops rapidly in the first 1,000 days of life, with the first six months and year being most important. In The Baby and the Biome, Meenal Lele, medical researcher and founder of Lil Mixins, the #1 pediatrician-recommended allergy-prevention product , explains how diet, environmental toxins, antibiotics, and even common parenting practices can damage the delicate balance of our children’s microbiomes, thereby increasing the risk for a host of immune diseases, including eczema, ...
Contact Dermatitis
Accompanying CD-ROM includes "all clinical photographs and important diagrams"--p. [vii].
