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Advances in neural reprogramming, disease modeling and therapeutic insights
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Pesticides
Pesticides are supposed to complete their intended function without "any unreasonable risk to man or the environment". Pesticides approval and registration are performed "taking into account the economic, social and environmental costs and benefits of the use of any pesticide". The present book documents the various adverse impacts of pesticides usage: pollution, dietary intake and health effects such as birth defects, neurological disorders, cancer and hormone disruption. Risk assessment methods and the involvement of molecular modeling to the knowledge of pesticides are highlighted, too. The volume summarizes the expertise of leading specialists from all over the world.
Neurodegenerative Diseases
As the global population ages the impact of neurodegenerative diseases like Alzheimer's disease and Parkinson's disease are significant forces in shaping human health and quality of life in the 21st century. Insights into understanding these diseases, and knowing how to treat them are major frontiers of scientific research. Neurodegenerative Diseases: Unifying Principles is the result of a conceptual revolution over the last decade in our understanding of neurodegenerative diseases as sharing unifying features. There is an increasing appreciation of the common biological and pathological features across seemingly varied neurodegenerative diseases that entail protein misfolding dysfunction an...
Stem Cells in Neurodegeneration: Disease Modeling and Therapeutics
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Neural Reprogramming
This detailed book brings together a number of state-of-the-art protocols to generate different types of neural cells through the use of reprogramming technologies. Additionally, the volume explores different aspects of functional evaluation and applications of reprogrammed neural cells as well as in silico methods to aid reprogramming efforts. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Neural Reprogramming: Methods and Protocols provides ample experimental experience and guidance for anyone, be it experienced researcher or beginner, to generate, validate, and apply reprogrammed neural cells in their research.
Autonomic Dysfunction in Parkinson's Disease
Autonomic dysfunction is one of the most prevalent non-motor symptoms that occurs in Parkinson's disease. Autonomic Dysfunction in Parkinson's Disease provides up to date information on this important topic, which affects quality of life of these patients. This include a large number of domains: orthostatic hypotension, excessive sweating, dry eyes, constipation, weight loss, increased sensitivity to heat and cold, sexual dysfunction. - Provides comprehensive reviews on different topics of autonomic dysfunction in Parkinson's disease - Each chapter covers a specific autonomic symptom: classification, assessment, treatment - Presents the newest information on each autonomic symptom in Parkinson's disease
Drug-like Properties: Concepts, Structure Design and Methods
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, typically only a fraction of these have sufficient ADME/Tox properties to become a drug product. Understanding ADME/Tox is critical for all drug researchers, owing to its increasing importance in advancing high quality candidates to clinical studies and the processes of drug discovery. If the properties are weak, the candidate will have a high risk of failure or be less desirable as a drug product. This book is a tool and resource for scientists engaged in, or preparing for, the selection and optimization process. The authors describe how properties affect in vivo pharmacol...
Genomic Control Process
Genomic Control Process explores the biological phenomena around genomic regulatory systems that control and shape animal development processes, and which determine the nature of evolutionary processes that affect body plan. Unifying and simplifying the descriptions of development and evolution by focusing on the causality in these processes, it provides a comprehensive method of considering genomic control across diverse biological processes. This book is essential for graduate researchers in genomics, systems biology and molecular biology seeking to understand deep biological processes which regulate the structure of animals during development. - Covers a vast area of current biological re...
Principles of Cognitive Neuroscience
Written by seven leading authors, the text covers the growing subject of cognitive neuroscience and makes clear the many challenges that remain to be solved. Now, in this second edition, the text has been streamlined to 15 chapters for ease of reference. The condensation makes the topics covered easier to assimilate, and better suited to presentation in a single-semester course. Each chapter has been updated to address the latest developments in the field, including expanded coverage of genetics, evolution, and neural development. Introductory Boxes in each chapter take up an especially interesting issue to better capture readers' attention. An appendix reviews the major features of human neuroanatomy and basic aspects of neural signaling. As before, this edition includes an extensive glossary of key terms. And, with every new copy of the book, we offer a fully upgraded version of Sylvius 4 Online, which includes an interactive tutorial on human neuroanatomy as well as a magnetic resonance imaging atlas of the human brain.
