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In recent years, major developments have increased understanding of various genetic and epigenetic regulatory processes that are critical for the generation of B cell repertoires. These include the role of chromatin regulation and nuclear organization in understating the IgH gene regulation. These proceedings highlight recent developments in lymphocyte development, Ig gene rearrangements and somatic hypermutation, chromatin structure modification, B lymphocyte signaling and fate, receptor editing, and autoimmunity.
Located midway between Yakima to the northwest and the Tri-Cities of Pasco, Kennewick, and Richland to the east, Grandview is central to the Northwests large urban centers of Seattle, Portland, and Spokane. The townsite was chosen in 1905 as the final stop on the Sunnyside branch of the local rail line. Early farmers were met with blowing sand and jackrabbits, but with the addition of irrigation, lush fruit orchards and champion corn soon replaced native sagebrush. In 1910, one year after incorporation, 320 people called Grandview home. In the 1920s, dairies, poultry farms, and a winery marked a further transformation to the landscape. By 1940, the acreage given over to grape vineyards had greatly increased, asparagus was becoming a major crop, and more than 400 acres of hops were harvested. To this day, Grandview remains a small town where farming and related industries are major employers.
Advances in Immunology, a long established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.
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