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Table of Contents List of contributors Preface Pt. 1 The cytoskeleton: the machinery and key molecules 1 1 Microtubules and microtubule-associated proteins 3 2 Actin and actin-modulating proteins 32 Pt. 2 Fundamental cytoskeletal activities 81 3 Expanding beyond the great divide: the cytoskeleton and axial growth 83 4 Re-staging plant mitosis 116 5 Organelle movements: transport and positioning 148 6 The cell wall: a sensory panel for signal transduction 176 Pt. 3 The cytoskeleton and plant cell morphogenesis 205 7 Development of root hairs 207 8 Signaling the cytoskeleton in pollen tube germination and growth 240 9 Cytoskeletal requirements during Arabidopsis trichome development 265 10 Signaling and the cytoskeleton in guard cells 290 Index 318.
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Completely revised and updated to incorporate the latest data in the field, Lewin's CELLS, Second Edition is the ideal resource for advanced undergraduate and graduate students entering the world of cell biology. Redesigned to incorporate new learning tools and elements, this edition continues to provide readers with current coverage of the structure, organization, growth, regulation, movements, and interaction of cells, with an emphasis on eukaryotic cells. Under the direction of three expert lead editors, new chapters on metabolism and general molecular biology have been added by subject specialist. All chapters have been carefully edited to maintain consistent use of terminology and to achieve a homogenous level of detail and rigor. A new design incorporates many new pedagogical elements, including Concept & Reasoning Questions, Methods boxes, Clinical Applications boxes, and more.
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The fundamental question of how cells grow and divide has perplexed biologists since the development of the cell theory in the mid-19th century, when it was recognized by Virchow and others that “all cells come from cells.” In recent years, considerable effort has been applied to the identification of the basic molecules and mechanisms that regulate the cell cycle in a number of different organisms. Such studies have led to the elucidation of the central paradigms that underpin eukaryotic cell cycle control, for which Lee Hartwell, Tim Hunt, and Paul Nurse were jointly awarded the Nobel Prize for Medicine and Physiology in 2001 in recognition of their seminal contributions to this field. The importance of understanding the fundamental mechanisms that modulate cell division has been reiterated by relatively recent discoveries of links between cell cycle control and DNA repair, growth, cellular metabolism, development, and cell death. This new phase of integrated cell cycle research provides further challenges and opportunities to the biological and medical worlds in applying these basic concepts to understanding the etiology of cancer and other proliferative diseases.
Concerns about the recent explosions of diseases like HIV, the West Nile Virus, and other avian and swine flus that originate in animals have encouraged new efforts on a global scale to bridge the gap between animal and human medicine for the benefit of both. Zoobiquity is the first book to explore many of the human and animal health issues that overlap and provides new insight into the treatment of many diseases including diabetes, cancer, heart disease and mental illness. But Zoobiquity is even bigger than health and academic medicine, and encompasses much more than our diseases and how to cure them. It sheds light on the evolution of hierarchies and similarities between a tribe of apes and a Fortune 500 company. It suggests that the ways we run our political and justice systems may overlap with how animals protect and defend their territories - and that examining this possibility in a scientifically credible way could help strengthen our institutions. It dangles the possibility that human parenting could be informed by a greater knowledge and respect for how our animal cousins solve issues of childcare, sibling rivalry and infertility.
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