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The M.D. Anderson Surgical Oncology Handbook
Written by current and former surgical oncology fellows of the world-renowned M.D. Anderson Cancer Center, this portable handbook is a practical guide to established surgical oncology principles for each organ system. This new Fourth Edition features extensive updates including new chapters on reconstructive surgery in the cancer patient. Concise chapters illustrated with algorithms and line drawings outline the essential elements of diagnosis, staging, and clinical management of solid tumors treated in surgical practice. The authors emphasize multidisciplinary treatment planning, including therapy sequencing and biologic therapies.
Principles and Practice of Surgical Oncology
Principles and Practice of Surgical Oncology uniquely emphasizes a multidisciplinary, integrated approach to the treatment of solid tumors. It presents treatment strategies that combine surgery with preoperative or postoperative adjunctive chemotherapy, hormonal therapy, and/or radiation therapy to achieve optimal outcome. The book features contributions from surgeons, basic scientists, pathologists, radiologists, radiation therapists, and medical oncologists and offers a comprehensive presentation of genetics, molecular biology, pathogenesis, and multimodal therapeutic approaches. A unique feature of the book is a commentary following each chapter, which describes alternative approaches and discusses controversial areas of current therapy. A companion Website will offer the fully searchable text with images.
Malignancies of the Groin
This volume provides the first comprehensive review of the surgical anatomy of the groin in over 30 years. The text also provides a detailed review of considerations for all disciplines involved with the management of neoplasms potentially involving the inguinal lymph node basin as well as describing, in detail, the complications which can occur if one’s understanding of these issues is limited. Epidemiology and the historical context in the evolution of our understanding of this anatomic area is covered along with lymphedema, one of the most concerning risks of groin surgery. Additionally, a thorough discussion of the management of all malignancies known to affect the inguinal region and ...
Merkel Cell Carcinoma
Merkel cell carcinoma is an uncommon but not rare aggressive cutaneous malignancy. It has many similarities to melanoma, particularly in the need for aggressive multidisciplinary treatment, but far less is known about this disease by most practicing physicians. This book summarizes all of the existing knowledge about Merkel cell carcinoma and provides a much-needed perspective on future opportunities for diagnostic and therapeutic advances. It offers practical ?how to? advice on diagnosis, treatment and follow-up, and also insight into how to establish a multidisciplinary Merkel cell carcinoma clinic. In addition, it will serve as a unique resource for trainees (medical students, residents and fellows) as well as for Merkel cell carcinoma patients and their advocates and caregivers. There is currently no such textbook, even an outdated one, covering this topic.
Antibody Drug Discovery
Antibody-based therapeutics are a central driver of the success of biopharmaceuticals. The discovery technology of this field is isolated to a limited number of centers of excellence in industry and academia. The objective of this volume is to provide a series of guides to those evaluating and preparing to enter particular areas within the field. Each chapter is written with a historical perspective that sets into context the significance of the key developments, and with the provision of “points to consider” for the reader as a value-added feature of the volume. All contributors are experts in their fields and have played pivotal roles in the creation of the technology.
MicroRNAs in Development and Cancer
MicroRNAs have recently emerged as key regulators of gene expression during development and are frequently misexpressed in human disease states, in particular cancer. These 22-nucleotide-long transcripts act to promote or repress cell proliferation, migration and apoptosis during development, all of which are processes that go awry in cancer. Thus, microRNAs have the ability to behave like oncogenes or tumor suppressors. In addition, their small size and molecular properties make them amenable as targets and therapeutics in cancer treatment. This book goes into detail on how microRNAs represent a paradigm shift in thinking about gene regulation during development and disease, and provide the oncologist with a potentially powerful new battery of agents to diagnose and treat cancer.
Melanoma, An Issue of Surgical Clinics, E-Book
This issue of Surgical Clinics of North America focuses on Contemporary Melanoma Management: A Surgical Perspective, and is edited by Dr. Rohit Sharma. Articles will include: Melanoma etiology and risk factors; Genetic, inherited and familial melanoma; Staging melanoma: What's old and new; Surgical management of primary cutaneous melanoma; Surgical management of regional lymph nodes in melanoma; Non-surgical management of regional lymph nodes in melanoma; Principles of immunotherapy in melanoma; Principles of targeted therapy in melanoma; Role of radiation in the era of effective systemic therapy for melanoma; Melanoma of unusual sites; Ongoing clinical trials in melanoma; Role of surgery for metastatic melanoma; Surgical considerations and systemic therapy of melanoma; Management of loco regionally advanced melanoma; Pathology of melanoma; and more!
Holland-Frei Cancer Medicine
Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Advances in Oncology, E-Book 2023
Advances in Oncology reviews the year's most important findings and updates within the field in order to provide practicing oncologists with the current clinical information they need to improve patient outcomes. A distinguished editorial board, led by Dr. Leonidas C. Platanias, identifies key areas of major progress and controversy and invites preeminent specialists to contribute original articles devoted to these topics. These insightful overviews in oncology inform and enhance clinical practice by bringing concepts to a clinical level and exploring their everyday impact on patient care. - Contains 25 articles on such topics as de-escalation therapy for HPV-associated oropharyngeal cancer;...
Alzheimer's Disease
Alzheimer's disease is the most common form of senile dementia, affecting more than 24 million people worldwide. It is characterised pathologically by abnormally high levels of neurofibrillary tangles resulting from the accumulation of tau protein in dead and dying neurons, and by elevated numbers of senile plaques in the cortex and hippocampus of the brain. The major component of senile plaques is a small protein of 39OCo43 amino acids called amyloid-? (A?). Thus far, no treatment has been shown to slow the progression of sporadic and familial Alzheimer's disease.A large body of evidence points, however, to the early A?-formed oligomers as the primary toxic species in Alzheimer's disease. A...
