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The chemical basis of human emotions has been an exciting aspect in biology. The "feel-good chemical" dopamine (DA) is a hormone and also a neurotransmitter, which performs a critical role in reward and movement control in the brain. DA also performs multiple other functions outside the brain. Regulating unrelated critical biological functions makes this chemical a vital factor for sustaining life in both health and disease. Dopamine - Health and Disease is an endeavour with an objective to understand and appreciate the biological functions of DA in human wellbeing and its potential utility in biomedical research. This effort will supplement scientific and non-scientific communities in stimulating a critical understanding of the biological purpose of "ticklish" DA, which eventually supports the human relentless effort to reduce the burden of disease. As the most exciting molecule,dopamine directly impacts day-to-day life. Anyone who has an eye for health and disease-related concepts will find this book a good read.
The book provides chapters on sex hormones and their modulation in neurodegenerative processes and pathologies, from basic molecular mechanisms, physiology, gender differences, to neuroprotection and clinical aspects for potential novel pharmacotherapy approaches. The book contains 14 chapters written by authors from various biomedical professions, from basic researchers in biology and physiology to medicine and veterinary medicine, pharmacologists, psychiatrist, etc. Chapters sum up the past and current knowledge on sex hormones, representing original new insights into their role in brain functioning, mental disorders and neurodegenerative diseases. The book is written for a broad range of audience, from biomedical students to highly profiled medical specialists and biomedical researchers, helping them to expand their knowledge on sex hormones in neurodegenerative processes and opening new questions for further investigation.
Neurotoxins are natural or chemical compounds that can disturb the neurological system of mammals. The neurotoxic potential of a neurotoxin is a consequence that may occur if tissue concentrations surpass a particular threshold. Chemicals disrupt adult brain function by interfering with the structure and function of various neuronal pathways, circuits, and systems in diverse ways. Neurotoxicity - New Advances provides updated information about neurotoxicity and neurotoxic chemicals including nanomaterials and pesticides. It also discusses prevention and treatment strategies. This book is an instructive and valuable guide to understanding neurotoxicity and identifying neurotoxicity mechanisms and neurotoxic disorders.
Chemical synapses are specialised junctions through which cells of the nervous system signal to one another and to non-neuronal cells such as muscles or glands. A chemical synapse between a motor neuron and a muscle cell is called a neuromuscular junction. Chemical synapses allow the neurons of the central nervous system to form interconnected neural circuits. They are thus crucial to the biological computations that underlie perception and thought. They also provide the means through which the nervous system connects to and controls the other systems of the body. The human brain contains a huge number of chemical synapses, with young children having about 1016 synapses (10,000 trillion[1].). This number declines with age, stabilising by adulthood. Estimates for an adult vary from 1015 to 5 × 1015 synapses (1,000 to 5,000 trillion).
Despite being described about 200 years ago, the pathophysiology of Parkinson’s disease (PD) is not well understood due to its complex etiology and heterogeneity of symptoms and progression. Animal models provide a great opportunity to follow the progression of neurodegeneration and to screen potent therapeutic molecules, knowledge of which can be critical for different levels of clinical trials. Contemporary health technologies are coming in handy to accelerate the pace of developing novel and refined therapeutic strategies for PD. This book, Parkinson’s Disease - Animal Models, Current Therapies and Clinical Trials, provides a comprehensive overview of PD, presenting information on animal models of PD and contemporary therapeutic strategies, health technologies, clinical trials, and their influence on the quality of life of patients with PD.
Population-based cancer registries across the world represent an important source of information on cancer incidence; these are used for many purposes, including a region-wise comparison of trends for different types of cancers and for generating hypotheses. Among the available statistics for studying cancer trends, the most valuable data is of ‘incidence rate’ that comes from recording every case of cancer in a defined geography in a specified time. But there is a downside in relying on published incidence rates from cancer registries. Namely, the published rates are not only determined by the real underlying cancer incidence rates, but also on such regional phenomena as access to diagnostic services/practices in the medical communities, quality and completeness of reporting of cancer diagnoses to the local cancer registries, quality of the cancer registry itself, and data management systems. These methodological aspects can vary from country to country and can even vary within countries.
“Mente sana en cuerpo sano” es un ideal que se ha promovido por generaciones y que deja en claro la estrecha relación que existe entre la psicología y la salud. Con el fin de abonar al desarrollo del campo del conocimiento sobre la vinculación entre estos dos componentes vitales del ser humano, esta obra presenta diversos trabajos teóricos y experimentales contemporáneos desarrollados en México en el campo de la psicología conductual. Los autores comparten tanto sus reflexiones, análisis y metodologías, como los conocimientos específicos, para que los aprovechen otros investigadores, académicos y estudiantes, tanto de pregrado como de posgrado, así como los profesionales de la salud, y de esta manera se puedan generar orientaciones novedosas en los procesos de diagnóstico e intervención para enfermedades concretas o problemas de salud socialmente significativos, como la adicción a las drogas, el mal de Parkinson o los trastornos alimenticios, a la par de favorecer el desarrollo de modelos experimentales y teóricos en esta disciplina. (ITESO)
Learning disability is a classification that includes several disorders in which a person has difficulty learning in a typical manner. Depending on the type and severity of the disability, interventions may be used to help the individual learn strategies that will foster future success. Some interventions can be quite simplistic, while others are intricate and complex. This book deserves a wide audience; it will be beneficial not only for teachers and parents struggling with attachment or behavior issues, but it will also benefit health care professionals and therapists working directly with special needs such as sensory integration dysfunction.
Assembles international authorities to address contemporary research in metal neurotoxicity. Essential and non-essential metals play an important role in neurodevelopmental and neurodegenerative diseases. Recent developments in understanding the role of metals in the etiology of these disorders have led to rapid growth in clarifying the pathology of some of the most devastating diseases we face and in identifying potential new therapies. Few books or periodicals have been wholly dedicated to the topic of metals, and this collection is intended to serve as a resource for all researchers interested in metals and their role in health and disease.