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Advances in Molecular and Pharmacological Mechanisms of Novel Targeted Therapies for Melanoma
Malignant melanoma is the most aggressive type of skin cancer with invasive growth patterns. Recent advances in melanoma management have focused on cell growth, proliferation, migration, and survival biomarkers. Numerous FDA-approved molecular-targeted therapies, such as tyrosine kinase inhibitors (TKIs), have been developed targeting genetic biomarkers that play a critical role in tumorigenesis when overexpressed. The use of targeted therapies as an alternative or adjuvant to immunotherapy has revolutionized the management of metastatic melanoma. Although this treatment strategy is more efficacious and less toxic than traditional therapies, targeted therapies are less effective after prolonged treatment due to acquired resistance given the mutations and activation of resistant mechanisms in melanoma tumors. In this sense, identifying novel target therapies and repositioned drugs that could modulate the disease progression, the potential molecular and pharmacological mechanisms of therapies are of utmost interest.
Nanotechnology
Nanotechnology: Advances and Real-Life Applications offers a comprehensive reference text about advanced concepts and applications in the field of nanotechnology. The text – written by researchers practicing in the field – presents a detailed discussion of key concepts including nanomaterials and their synthesis, fabrication and characterization of nanomaterials, carbon-based nanomaterials, nano-bio interface, and nanoelectronics. The applications of nanotechnology in the fields of renewable energy, medicine and agriculture are each covered in a dedicated chapter. The text will be invaluable for senior undergraduate and graduate students in the fields of electrical engineering, electronics engineering, nanotechnology and nanoscience. Dr. Cherry Bhargava is an Associate Professor and Head, VLSI domain, at the School of Electrical and Electronics Engineering of Lovely Professional University, Jalandhar, India. Dr. Amit Sachdeva is an Associate Professor at Lovely Professional University, Jalandhar, India.
Brazil in Advancing Pharmacotherapy and Clinical Pharmacy in Latin America
The Fourth Brazilian Congress of Pharmacotherapy and Clinical Pharmacy showcases Brazil's role within the vibrant and evolving community of pharmacotherapy and clinical pharmacy in Latin America. This volume offers a window into Brazil's ongoing contributions as part of a collective Latin American effort, presenting a comprehensive collection of scientific investigations and documented clinical experience reports that address important healthcare challenges. Containing hundreds of peer-reviewed works, evaluated through a double-blind review process, this publication documents ongoing progress in evidence-based, patient-centered pharmaceutical care. The compilation adheres to rigorous scientific standards, with submissions evaluated for methodological soundness, clinical relevance, and adherence to ethical guidelines. Systematically organized to facilitate knowledge transfer, this resource offers understandings into emerging therapeutic protocols, pharmacological interventions, and clinical decision-making frameworks. For researchers, clinicians, and policymakers, this publication provides an essential, data-driven foundation for advancing pharmaceutical practice in the region.
Proceedings of the 6th Brazilian Technology Symposium (BTSym’20)
This book presents the Proceedings of The 6th Brazilian Technology Symposium (BTSym'20). The book discusses the current technological issues on Systems Engineering, Mathematics and Physical Sciences, such as the Transmission Line, Protein-Modified Mortars, Electromagnetic Properties, Clock Domains, Chebyshev Polynomials, Satellite Control Systems, Hough Transform, Watershed Transform, Blood Smear Images, Toxoplasma Gondi, Operation System Developments, MIMO Systems, Geothermal-Photovoltaic Energy Systems, Mineral Flotation Application, CMOS Techniques, Frameworks Developments, Physiological Parameters Applications, Brain–Computer Interface, Artificial Neural Networks, Computational Vision,...
Universities, Entrepreneurial Ecosystems, and Sustainability
This volume presents theoretical and empirical research on universities and their entrepreneurial ecosystems to better grasp the connections between universities and their surrounding environments and their engagement with sustainability. The book provides a better understanding of the entrepreneurial characteristics of universities. It examines the ways in which universities’ collaboration and participation in an ecosystem support business and industry transformation. It also investigates how universities function within the university/industry/government/third sector relationship nexus. The book enables the systematisation of the literature while simultaneously builds theory, empirically testing existing theories, and contributes towards a future research agenda geared towards sustainability. The book gathers contributions from varied geographical contexts providing an international perspective.
The Oracle of Night
*THE INTERNATIONAL BESTSELLER* What is a dream? Why do we dream? How do our bodies and minds use dreams? These questions are the starting point for this unprecedented, astonishing study of the role and significance of dreams, from the beginning of human history. An investigation on the grand scale, encompassing literature, anthropology, religion, and science, it articulates the essential place dreams occupy in human culture, and how they functioned as the catalyst that compelled us to transform our earthly habitat into a human world. From the earliest cave paintings - where the author finds a key to humankind's first dreams, which contributed to our capacity to perceive past and future - to ...
Cardiovascular Surgery
This clinical casebook is comprised of surgical cases involving the most important cardiovascular diseases in a concise, easy-to-read format (5x8 in trim size, like other titles in this burgeoning, informal product line in the Springer clinical medicine program). Each chapter is a case that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and management techniques used to treat it, as well as questions and answers (between 8 and 10) about relevant aspects related to the diagnosis and treatment of the addressed disease. The Q&A section will broaden discussion and increase the title's pedagogical value. The casebook features 40 surgical cases in...
Cancer Clinical Pharmacology
The book considers both the theory and practice of clinical pharmacology where it is relevant to cancer treatment. It covers the basics of clinical pharmacology in oncology and cancer therapeutics, discussing the specific classes of anti-cancer agents in detail. Edited and written by a mix of generalist cancer clinical pharmacologists and sub-specialists within this area, the book allows the reader to develop both general clinical pharmacology skills and specialist knowledge for particular cancer chemotherapy agents.
Toxoplasmosis
Scientific motivation to publish this book comes from the increased interest in the study of toxoplasmosis, showed all over the world. Though the Toxoplasma gondii infection was first discovered in 1908, toxoplasmosis remains a today's research topic, a realm of questions and dilemmas that interest both the veterinarians and the human doctors. Studies in the field are directed to the epidemiology of the disease, the sources of infection, epidemiological chains, being underlined the important feature in the transmission of this parasite: the ability to pass from one intermediate host to another intermediate host without passing through the final host - felids. An increased prevalence of toxop...
