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Won for All
This is the story of the sequencing of the fly genome as told by one of the participants, Michael Ashburner. Written in a diary-like form, half the story is told in numerous footnotes. Ashburner has written a delightful, candid, irreverent, on-the-scene tale filled with eccentric personalities all focused on a single goal. The book also contains an Epilogue that puts Drosophilaas a model system in historical context, and an Afterword that discusses the impact the genome sequence has had on the study of Drosophila.Also included are portraits by Lewis Miller of some of the principal characters. About the author:Michael Ashburner is Professor of Biology in the Department of Genetics at the University of Cambridge. By training and inclination, he is a Drosophilageneticist, although for more than a decade, he has not been where he belongs – the lab bench – but in front of computer screens. He spent six years at the European Bioinformatics Institute, first as the Institute's Research Programme Coordinator, and then as its Joint-Head. He is a Fellow of the Royal Society and an Honorary Foreign Member of the American Academy of Arts and Sciences.
Drosophila Protocols
This exceptional laboratory manual describes thirty-seven procedures most likely to be used in the next decade for molecular, biochemical, and cellular studies on Drosophila. They were selected after extensive consultation with the research community and rigorously edited for clarity, uniformity, and conciseness.The methods included permit investigation of chromosomes, cell biology, molecular biology, genomes, biochemistry, and development. Each protocol includes the basic information needed by novices, with sufficient detail to be valuable to experienced investigators. Each method is carefully introduced and illustrated with figures, tables, illustrations, and examples of the data obtainable. The book's appendices include key aspects of Drosophila biology, essential solutions, buffers, and recipes.An evolution of Michael Ashburner's 1989 classic Drosophila: A Laboratory Manual, this book is an essential addition to the personal library of Drosophila investigators and an incomparable resource for other research groups with goals likely to require fly-based technical approaches.
Human Brain Function
This updated second edition provides the state of the art perspective of the theory, practice and application of modern non-invasive imaging methods employed in exploring the structural and functional architecture of the normal and diseased human brain. Like the successful first edition, it is written by members of the Functional Imaging Laboratory - the Wellcome Trust funded London lab that has contributed much to the development of brain imaging methods and their application in the last decade. This book should excite and intrigue anyone interested in the new facts about the brain gained from neuroimaging and also those who wish to participate in this area of brain science.* Represents an almost entirely new book from 1st edition, covering the rapid advances in methods and in understanding of how human brains are organized* Reviews major advances in cognition, perception, emotion and action* Introduces novel experimental designs and analytical techniques made possible with fMRI, including event-related designs and non-linear analysis
Statistical Parametric Mapping: The Analysis of Functional Brain Images
In an age where the amount of data collected from brain imaging is increasing constantly, it is of critical importance to analyse those data within an accepted framework to ensure proper integration and comparison of the information collected. This book describes the ideas and procedures that underlie the analysis of signals produced by the brain. The aim is to understand how the brain works, in terms of its functional architecture and dynamics. This book provides the background and methodology for the analysis of all types of brain imaging data, from functional magnetic resonance imaging to magnetoencephalography. Critically, Statistical Parametric Mapping provides a widely accepted concept...
Insect Ultrastructure
Cell biology is moving at breakneck speed, and many of the results from studies on insects have helped in understanding some of the central problems of biology. The time is therefore ripe to provide the scientific community with a series of up-to-date, well illustrated reviews of selected aspects of the sub microscopic cytology of insects. The topics we have included fall into four general groups: seven chapters deal with gametogenesis, four concern develop ing somatic cells, seventeen chapters describe specialized tissues and organs, and three chapters cover cells in pathological states. These accounts are illustrated with over 600 electron micrographs. The more than 1100 pages in the two v...
Biology of Drosophila
Biology of Drosophila was first published by John Wiley and Sons in 1950. Until its appearance, no central, synthesized source of biological data on Drosophila melanogaster was available, despite the fly's importance to science for three decades. Ten years in the making, it was an immediate success and remained in print for two decades. However, original copies are now very hard to find. This facsimile edition makes available to the fly community once again its most enduring work of reference.
Advances in Genetics
Advances in Genetics increases its focus on modern human genetics and its relation to medicine with the merger of this long-standing serial with Molecular Genetic Medicine. This merger affirms the Academic Press commitment to publish important reviews of the broadest interest to geneticists and their colleagues in affiliated disciplines. Volume 39 of Advances in Genetics completes the trilogy of volumes authored by Dr. Igor Zhimulev of the Institute of Cytology and Genetics in Novosibirsk, Russia. This set comprises what is perhaps the most comprehensive collection of volumes dedicated to the study of polytene chromosomes. Volume 39 picks up where the previous two volumes, 34 and 37, left off. It covers the organization of genetic material in the morphological structures of the interphase chromosome, the chromomeres and the interchromomeric regions, and the structural changes occurring during the activation of the chomomeres, the puffs.
Drosophila melanogaster, Drosophila simulans: So Similar, So Different
This book brings together most of the information available concerning two species that diverged 2-3 million years ago. The objective was to try to understand why two sibling species so similar in several characteristics can be so different in others. To this end, it was crucial to confront all data from their ecology and biogeography with their behavior and DNA polymorphism. Drosophila melanogaster and Drosophila simulans are among the two sibling species for which a large set of data is available. In this book, ecologists, physiologists, geneticists, behaviorists share their data on the two sibling species, and several scenarios of evolution are put forward to explain their similarities and divergences. This is the first collection of essays of its kind. It is not the final point of the analyses of these two species since several areas remain obscure. However, the recent publication of the complete genome of D. melanogaster opens new fields for research. This will probably help us explain why D. melanogaster and D. simulans are sibling species but false friends.
Biochemistry
The underlying theme of this volume is the understanding of the molecules and processes important in the primary metabolism of insects. The 19 chapters provide both rich historical perspectives and timely reviews of current research, as well as showing the extent of progress to be expected in the near future, including the application of advanced techniques now used for the study of microbial and mammalian processes. The major themes of metabolism, proteins and nucleic acids, and biochemical events in the nervous system each have several chapters devoted to them, but specific topics such as pigments, toxins, and aging are also covered in detail. This extensive volume is therefore an invaluable source of information not only for entomologists but also for all scientists whose work involves insect biochemistry, including zoologists, biochemists, and molecular biologists and geneticists.
