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This volume presents a snapshot of some of the most important ongoing research in cancer. With cancer as the second leading cause of death worldwide, extensive research is going on globally to decipher the molecular mechanism underlying cancer that will help in finding better targets for drug therapy. The book brings together new research on molecular mechanism and cancer therapeutics in one place. With chapters from experts in their respective fields, chapters cover molecular mechanisms, etiology, prognosis, detection, and treatment of cancer. Emphasis has been given to the intricate mechanism behind the deregulation of cell division, disruption of cell cycle check points, mutation in oncogenes and tumor suppressor genes, apoptosis, and erratic cell signaling. The book discusses in detail topics such as angiogenesis and tumor microenvironment, which are increasingly receiving attention, especially in the field of neoplastic vascularization and metastasis. The book also includes chapters detailing the current understanding and the future perspective of cancer stem cells.
"Despite the significant advances in cancer therapy made through constant evaluation and analysis of treatment aftereffects, the disease still remains one of the foremost causes of mortality worldwide killing more than 12 million people annually. The prime reason behind the failure of conventional chemotherapeutics which are used as the chief regimen in the comprehensive treatment of cancers is the development of chemoresistance. It can be either intrinsic or acquired and is primarily mediated via different key regulators like MDR, MAPK, NF-κB, PI3K/Akt, Wnt signaling pathways etc. Thus, agents which can target these regulatory elements or pathways and in turn sensitize cancer cells to chem...
Encyclopedia of Renewable and Sustainable Materials, Five Volume Set provides a comprehensive overview, covering research and development on all aspects of renewable, recyclable and sustainable materials. The use of renewable and sustainable materials in building construction, the automotive sector, energy, textiles and others can create markets for agricultural products and additional revenue streams for farmers, as well as significantly reduce carbon dioxide (CO2) emissions, manufacturing energy requirements, manufacturing costs and waste. This book provides researchers, students and professionals in materials science and engineering with tactics and information as they face increasingly c...
Microfinance is a useful tool for reducing poverty and building the capacity of the poor in management of sustainable self-employment, by way of providing financial services like credit, saving, housing consumption credit, insurance cover, etc. This book takes a holistic view of the various aspects of the microfinance programmes as adopted under Swarnajayanti Gram Swarozgar Yojana (SGSY) in India, with special reference to the state of West Bengal. Critically examining how SGSY operates in relation to funding the programme, bank linkage system, training and capacity building of beneficiaries, thrift, credit and governance systems of SHGs, marketing of SHG products, role of bankers and NGOs, and the perceptions of the beneficiaries. It also analyses the impact of the SGSY programmes on the socio-economic empowerment of SHG members.
An estimated 12.6 million people are diagnosed with cancer every year and 7.6 million people die of the disease annually. Numerous lines of evidence suggest that lifestyle and nutrition play an important role in cancer development. As for nutrition, diets that are rich in fruits and vegetables have been shown to lower the risk of cancer incidence. In addition, several phytochemicals that are present in fruits and vegetables have been scientifically established to have properties that can prevent and treat this malevolent disease.The primary aim of the book is to educate the public about the benefits of fruits and vegetables as they relate to cancer and their potential to contribute to the po...
Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field.Animal biotechnology ...
Dating from 1919 to 1940, these letters and telegrams are being published for the first time in English in their entirety. They manage to capture the essence of Tagore and Rolland’s friendship in their struggle with the conflict between nationalism and human conscience. This volume also presents three important conversations the two engaged in at various points in time, as well as letters by Rathindranath Tagore and others, and lays out the journey of these two writers towards the imaging of a different world outside jingoistic politics. This correspondence presents the finest exchange of thought between the East and the West, and scripts the intellectual history of early twentieth century.
Part of a new series on reproductive medicine, this book is a complete guide to andrology and embryology. Divided into 38 chapters, the text begins with in depth discussion on male infertility covering sperm function tests, screening, sperm selection for ART, sperm banking, and various causes of male infertility. The second part of the book examines assisted reproductive techniques in male infertility, frozen embryo transfer, oocyte and embryo cryopreservation, third party reproduction, and more. The book presents the latest advances in the field and each chapter includes key points and references for further reading. Clinical photographs, diagrams and tables further enhance the comprehensive text. Other titles in the series include: Practical Guide in Infertility, Practical Guide in Reproductive Surgery and Practical Guide in Assisted Reproductive Technology. Key points Comprehensive guide to andrology and embryology Part of new series on reproductive medicine Covers numerous ART procedures for male infertility Chapters include key points and detailed references for further reading
This book presents the latest research on advances in genetics, molecular medicine, biotechnologies, and behavioural sciences that have an impact on primary, secondary and tertiary cancer prevention including: (a) Basic mechanisms of neoplastic diseases leading to the identification of molecular pathways that can be employed as targets for cancer prevention; (b) Descriptive, analytical, and molecular epidemiology with emphasis on developing biomarkers of cancer risk assessment and response to cancer prevention; (c) Laboratory and clinical procedures for prognostic evaluation of malignant tumour transformation, progression and response to treatment with cancer preventive agents; (d) Discoveries of natural substances and synthetic agents that have promising cancer preventive potential and elucidating their mechanistic action; (e) Development and assessment of cancer preventive approaches that have potential for being translated into the clinic; (f) Cancer prevention pre-clinical studies and clinical trials; (g) Patient management and education, management of curable lesions, education and lifestyle modification and the role of behavioural factors in cancer etiology and prevention.
Although it is preventable and curable, cervical cancer is the fourth most common form of cancer among women worldwide. As such, the World Health Organization adopted a Cervical Cancer Elimination Initiative, which aims to eliminate cervical cancer by 2030. This book discusses plans, programs, strategies, solutions, research, and revolutions necessary to achieve this goal. Chapters cover such topics as epidemiology, HPV vaccination, screening and treatment, and prevention and control.