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We are delighted to present the inaugural Frontiers in Cardiovascular Medicine “Rising Stars” article collection. This collection showcases the high-quality work of internationally recognized researchers in the early stages of their independent careers. All Rising Star researchers were individually nominated by the Chief Editors of the Journal in recognition of their potential to influence the future directions in their respective fields. The work presented here highlights the diversity of research performed across the entire breadth of cardiovascular medicine, including the elucidation of fundamental biology, the development of novel diagnostics or therapeutics, computational modelling approaches, and bioengineering strategies for regeneration.
Cardiac implantable device (CIED) infections are a key issue since they have serious consequences in terms of morbidity, mortality and associated costs for healthcare systems. Such infections are highly complex, which has implications for prevention (several factors underlie its development), diagnosis (requiring patient specific integration of several elements), acute treatment (choice of the antibiotic, lead extraction procedure), as well as long-term management (CIED re-implantation strategy and follow-up). Dealing with CIED infections requires appropriate organization of healthcare provision, with the creation of integrated hub-spoke referrals, and it has prompted many of the recent deve...
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The combination of molecular biology, engineering and bioinformatics has revolutionized our understanding of cancer revealing a tight correlation of the molecular characteristics of the primary tumor in terms of gene expression, structural alterations of the genome, epigenetics and mutations with its propensity to metastasize and to respond to therapy. It is not just one or a few genes, it is the complex alteration of the genome that determines cancer development and progression. Future management of cancer patients will therefore rely on thorough molecular analyses of each single case. Through this book, students, researchers and oncologists will obtain a comprehensive picture of what the first ten years of cancer genomics have revealed. Experts in the field describe, cancer by cancer, the progress made and its implications for diagnosis, prognosis and treatment of cancer. The deep impact on the clinics and the challenge for future translational research become evident.
This volume contains the proceedings of the Alexandre Vinogradov Memorial Conference on Diffieties, Cohomological Physics, and Other Animals, held from December 13–17, 2021, at the Independent University of Moscow and Moscow State University, Moscow, Russia. The papers are devoted to various interrelations of nonlinear PDEs with geometry and integrable systems. The topics discussed are: gravitational and electromagnetic fields in General Relativity, nonlocal geometry of PDEs, Legendre foliated cocycles on contact manifolds, presymplectic gauge PDEs and Lagrangian BV formalism, jet geometry and high-order phase transitions, bi-Hamiltonian structures of KdV type, bundles of Weyl structures, Lax representations via twisted extensions of Lie algebras, energy functionals and normal forms of knots, and differential invariants of inviscid flows. The companion volume (Contemporary Mathematics, Volume 789) is devoted to Algebraic and Cohomological Aspects of PDEs.