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New insights into innate immune cell-based immunotherapies in cancer
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Brain Injury
Brain Injury is the second volume in the book series, Molecular and Cellular Biology of Critical Care Medicine. In this volume, a group of internationally regarded experts in important areas of neuroscience and neurointensive care research address the molecular and cellular basis of acute brain injury. This text covers acute brain injury within a context relevant to the care of patients with critical neurologic injuries such as cardiac arrest, trauma and stroke. It includes recent data pertaining to established pathways such as neurotransmission, exitotoxicity, ionic-mechanisms, oxidative stress, inflammation, and cerebral vascular injury. In addition, rapidly developing areas such as cell signaling, adenosine pharmacology, apoptosis, mitochondrial dysfunction, neurocytoskeletal changes, and the role of trophic factors are reviewed from the level of in vitro modeling to human data. Other topics covered that are highly clinically relevant include the effect of genetic background and gender differences in outcome after brain injury, preconditioning, and the effects of currently used anesthetics and sedative agents in patients with brain injury.
International Review of Cytology
International Review of Cytology presents current advances and comprehensive reviews in cell biology—both plant and animal. Articles address structure and control of gene expression, nucleocytoplasmic interactions, control of cell development and differentiation, and cell transformation and growth. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. - Authored by some of the foremost scientists in the field - Provides up-to-date information and directions for future research - Valuable reference material for advanced undergraduates, graduate students and professional scientists
Innate Tolerance in the CNS
Cerebral preconditioning is a phenomenon wherein a mild insult or stress induces cellular and tissue adaptation or tolerance to a later, severe injury, therefore reflecting the efficacy of endogenous mechanisms of cerebrovascular protection. Initially identified for rapid cardiac protection, preconditioning has expanded to all aspects of CNS protection from ischemia, trauma and potentially neurodegeneration. Many different stimuli or stressors have been identified as preconditioning agents, suggesting a downstream convergence of mechanisms and underscoring the potential for translational application of preconditioning in the clinic. Moreover, the fundamental mechanisms responsible for precon...
Simulation and Modeling Methodologies, Technologies and Applications
This book includes a set of selected best-extended papers from the 10th International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2020) that was held as an online event from July 8 to 10, 2020. The conference brought together researchers, engineers, and practitioners interested in methodologies and applications of modeling and simulation. New and innovative solutions are reported in this book. A selection was made after the conference, based also on the conference chairs assessment, reviewers’ assessment, quality of presentation, and audience interest, so that this book includes the extended and revised versions of the very best papers of the conference.
Simulation and Modeling Methodologies, Technologies and Applications
This present book includes a set of selected best extended papers from the 12th International Conference on Simulation and Modeling Methodologies, Technologies and Applications (SIMULTECH 2022), that was held in Lisbon, Portugal, from July 14 to 16, 2022. The conference brought together researchers, engineers and practitioners interested in methodologies and applications of modeling and simulation. New and innovative solutions are reported in this book. A selection was made after the conference, based also on the conference chairs assessment, reviewers’ assessment, quality of presentation and audience interest, so that this book includes the extended and revised versions of the very best papers of the conference. New and innovative solutions are reported in this book.
50th Anniversary of Adult Neurogenesis: Olfaction, Hippocampus and beyond
In the mid-sixties, the discovery by Altman and co-workers of neurogenesis in the adult brain changed the previous conception of the immutability of this organ during adulthood sustained among others by Cajal. This discovery was ignored up to eighty’s when Nottebohm demonstrated neurogenesis in birds. Subsequently, two main neurogenic zones were characterized: the subventricular zone of the lateral ventricle and the subgranular layer of the dentate gyrus. Half century later, the exact role of new neurons in the adult brain is not completely understand. This book is composed by a number of articles by leaders in the filed covering from an historic perspective to potential therapeutic opportunities.
Update on Translational Neuroimmunology - Research of ISNI 2018
The 14th International Congress of Neuroimmunology, ISNI 2018, was held in August 2018 in Brisbane, Australia, and is a biennial event organized by the International Society of Neuroimmunology (ISNI). The theme of ISNI 2018 was “Travelling the Neuroimmunological Translational Highway”, and the Congress highlighted many research discoveries that bridge the gap between basic and clinical sciences, and which impact our understanding of pathogenic immune-mediated mechanisms in diseases affecting the nervous system. In this Research Topic, we aim to give a comprehensive overview of topics highlighted at the Congress, showcasing the current state of the field of neuroimmunology and where it is going in the near future.
