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Biological Calcification: Cellular and Molecular Aspects
The deposition of calcium-containing salts is a widespread phenomenon in both the plant and animal kingdoms. Its occurrence suggests a generalized biological adaptation to environments rich in calcium. Indeed, the Archaean ocean was rich in calcium carbonate, and traces of ancient organisms have been found in lime stones estimated to be about 2. 7 billion years old. The fundamental nature of biological calcification makes it a subject of interest not only to the student of calcium metabolism and skeletal physiology, but also to biologists in general. As in many areas of biological science recent progress in this field has been rapid, and no attempt was made here to cover all the biological s...
Clinical Impact of Bone and Connective Tissue Markers
For many years, biochemical tests have been widely used for the diagnosis, classification, and monitoring of bone and connective tissue disease. However, shortcomings in terms of the specificity and sensitivity of such tests have prompted continual questioning about their clinical usefulness.This book, based on a meeting organized jointly by the University of Uppsala and Pharmacia Diagnostics AB, reviews our current understanding of basic bone and connective tissue biochemistry and the clinical role of biochemical markers specific to related diseases, with special reference to rheumatoid arthritis and osteoporosis.
Medical Mineralogy and Geochemistry
Volume 64 of Reviews in Mineralogy and Geochemistry presents examples that include the effects of inhaled dust particles in the lung (Huang et al. 2006; Schoonen et al. 2006), biomineralization of bones and teeth (Glimcher et al. 2006), the formation of kidney-stones, the calcification of arteries, the speciation exposure pathways and pathological effects of heavy metal contaminants (Reeder et al. 2006; Plumlee et al. 2006), the transport and fate of prions and pathological viruses in the environment (Schramm et al. 2006), the possible environmental-genetic link in the occurrence of neurodegenerative diseases (Perl and Moalem 2006), the design of biocompatible, bioactive ceramics for use as orthopaedic and dental implants and related tissue engineering applications (Cerruti and Sahai 2006) and the use of oxide-encapsulated living cells for the development of biosensors (Livage and Coradin 2006).
